Advances in studies on biosynthetic pathways of camptothecin and their synthases

Chinese Traditional and Herbal Drugs

Volumn 42, Issue 9, 2011, Pages 1862-1868

  Shen, Shao Hua ^a   Liu, Ji Yan ^a   Hu, Jiang Qin ^a   Li, Xuan Han ^a   Wang, Li Lin ^a  

^a HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

Biosynthetic pathway; Camptotheca acuminata Decne; Camptothecin (CPT); Key enzyme; Secondary metabolism

Indexed keywords

CAMPTOTHECIN; SYNTHETASE;

BIOSYNTHESIS; DRUG SYNTHESIS; MEDICAL RESEARCH; REVIEW;

EID: 80054809181     PISSN: 02532670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Wall M E, Wani M C, Cooke E C, et al. Plant antitumor agents I. the isolation and structure of camptothecin. a novel alkaloidal leukaemia and tumor inhibitor from Camptotheca acuminata [J]. J Am Chem Soc, 1966, 88: 3888-3890.
2. Hisang Y H, Herizberg R, Hecht S, et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase [J]. J Biol Chem, 1985, 260(27): 14873-14878. (Pubitemid 16211028)
3. Sharma A, Chhikara S, Ghodekar S N, et al. Camptothecin: discovery and developments [J]. Pharm Rev, 2008, 2(4): 219-228.
4. Tan C, Cai L Q, Wu W, et al. NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells [J]. Cancer Chemother Pharmacol, 2009, 63: 303-312.
5. Zhang W, Song J J, Mu L Y, et al. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P [J]. Bioorg Med Chem Lett, 2011, 21(5): 1452-1455.
6. Lee D H, Kim S W, Suh C, et al. Belotecan, new camptothecin analogue, is active in patients with small-cell lung cancer: results of a multicenter early phase II study [J]. Ann Oncol, 2008, 19(1): 123-127.
7. Creemers J P, Despas R, Favalli G, et al. Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study [J]. J Clin Oncol, 1996, 14: 3056-3061.
8. Watase I, Sudo H, Yamazaki M, et al. Regeneration of transformed Ophiorrhiza pumila plants producing camptothecin [J]. Plant Biotechnol, 2004, 21(5): 337-342. (Pubitemid 40263454)
9. Lu H, McKnight T D. Tissue-specific expression of the β-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant [J]. Plant Physiol, 1999, 120: 43-51. (Pubitemid 29375407)
10. Lopez-Meyer M, Nessler C L. Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress [J]. Plant J, 1997, 11(6): 1167-1175. (Pubitemid 27308770)
11. Burnett R J, Maldonado-Mendoza I E, McKnight T D, et al. Expression of a 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Camptotheca acuminata is differentially regulated by wounding and methyl jasmonate [J]. Plant Physiol, 1993, 103: 41-48.
12. Maldonado-Mendoza I E, Vincent R M, Nessler C L. Molecular characterization of three differentially expressed members of the Camptotheca acuminata 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) gene family [J]. Plant Mol Biol, 1997, 34: 781-790. (Pubitemid 27354076)
13. 9-tetrahydrocannabinol in Cannabis saliva L. at flowering stage [J]. Plant Growth Regul, 2009, 58: 269-277.
14. Yamazaki Y, Sudo H, Yamazaki M, et al. Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds [J]. Plant Cell Physiol, 2003, 44(4): 395-403. (Pubitemid 36557685)
15. Lu Y, Wang H S, Wang W, et al. Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica [J]. Mol Biol Rep, 2009, 36: 1845-1852.
16. Bidle K A, Hanson T E, Howell K et al. HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii [J]. Extremophiles, 2007, 11: 49-55. (Pubitemid 46089629)
17. Shen G A, Pang Y Z, Wu W H, et al. Cloning and characterization of a root-specific expressing gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Ginkgo biloba [J]. Mol Biol Rep, 2006, 33: 117-127.
18. Lukács G, Papp T, Somogyvári F, et al. Cloning of the Rhizomucor miehei 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene and its heterologous expression in Mucor circinelloides [J]. Antonie Leeuwenhoek, 2009, 95: 55-64.
19. Kang S, Kang K, Lee K, et al. Characterization of rice tryptophan decarboxylasesand their direct involvement in serotonin biosynthesisin transgenic rice [J]. Planta, 2007, 227: 263-272. (Pubitemid 350222843)
20. Valletta A, Trainotti L, Santamaria A R, et al. Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne. (Nyssaceae) [J/OL]. BMC Plant Biol, doi: 10.1186/1471-2229-10-69,2010.
21. Yao H Y, Gong Y F, Zuo K J, et al. Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata [J]. J Plant Physiol, 2008, 165: 203-213.
22. Carretero-Paulet L, Cairó A, Botella-Pavía P, et al. Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants over expressing deoxyxylulose 5-phosphate reductoisomerase [J]. Plant Mol Biol, 2006, 62: 683-695. (Pubitemid 44652258)
23. Yan X M, Zhang L, Wang J, et al. Molecular characterization and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene from Salvia miltiorrhiza [J]. Acta Physiol Plant, 2009, 31 (5): 1015-1022.
24. Fits V L, Memelink J. ORCA3, a jasmonate responsive transcriptional regulator of plant primary and secondary metabolism [J]. Science, 2000, 289: 295-97. (Pubitemid 30469906)
25. Singh N, Avery M A, McCurdy C R. Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations [J]. J Comput Aided Mol Des, 2007, 21: 511-522. (Pubitemid 350048150)
26. Liu K H, Ding X W, Deng B W, et al. 10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata [J]. Biotechnol Lett, 2010, 32: 689-693.
27. Kusari S, Zühlke S, Spiteller M. An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues [J]. J Nat Prod, 2009, 72: 2-7.
28. Shweta S, Zuehlke S, Ramesha B T, et al. Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxy-camptothecin [J]. Phytochemistry, 2010, 71: 117-122.