NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 2, 2009, Pages 303-312

  Tan, Chen ^a   Cai, Li Qun ^a   Wu, Wendy ^a   Qiao, Yaming ^a   Imperato Mcginley, Julianne ^a   Chen, Guo Qiang ^b   Zhu, Yuan Shan ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Camptothecin analog; Mitochondria; Prostate cancer; Topoisomerase 1

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CAMPTOTHECIN DERIVATIVE; CASPASE 3; CASPASE 7; CYTOCHROME C; DNA TOPOISOMERASE; NSC 606985; PROTEIN BAK; PROTEIN BAX; ROTTLERIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN LNCAP; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DNA FRAGMENTATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROSTATE CANCER; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CAMPTOTHECIN; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMANS; MALE; PROSTATIC NEOPLASMS;

EID: 57149126339     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0740-8     Document Type: Article

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