Differential effects of Nociceptin/Orphanin FQ (NOP) receptor agonists in acute versus chronic pain: Studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 2, 2011, Pages 687-693

  Khroyan, Taline V ^a   Polgar, Willma E ^a   Orduna, Juan ^a   Montenegro, Jose ^a   Jiang, Faming ^a   Zaveri, Nurulain T ^b   Toll, Lawrence ^a  

^a SRI INTERNATIONAL   (United States)

^b Astraea Therapeutics Inc   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYCLOOCTYLPIPERIDIN 4 YL)INDOLIN 2 ONE; 1 [1 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALEN 1 YL)PIPERIDINL 4 YL]INDOLIN 2 ONE; 7 [4 (2,6 DICHLOROPHENYL) 1 PIPERIDINYLMETHYL] 6,7,8,9 TETRAHYDRO 1 METHYL 5H BENZOCYCLOHEPTEN 5 OL; ANALGESIC AGENT; CIS 1 METHYL 7 [[4 (2,6 DICHLOROPHENYL)PIPERIDIN 1 YL]METHYL] 6,7,8,9 TETRAHYDRO 5H BENZOCYCLOHEPTEN 5 OL; MORPHINE; NALOXONE; NOCICEPTIN RECEPTOR; SR 14150; SR 16835; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIALLODYNIC ACTIVITY; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LATENT PERIOD; MALE; MOUSE; NERVE LIGATION; NONHUMAN; PRIORITY JOURNAL; SCIATIC NERVE; TAIL FLICK TEST; UPREGULATION;

ACUTE PAIN; ANIMALS; CHRONIC PAIN; CYCLOHEPTANES; HOT TEMPERATURE; HYPERALGESIA; INDOLES; LIGATION; MALE; MICE; MICE, INBRED ICR; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; PIPERIDINES; RECEPTORS, OPIOID; SCIATIC NERVE;

EID: 80054789914     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.184663     Document Type: Article

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