A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor

Journal of Medicinal Chemistry

Volumn 47, Issue 12, 2004, Pages 2973-2976

  Zaveri, Nurulain T ^a   Jiang, Faming ^a   Olsen, Cris M ^a   Deschamps, Jeffrey R ^b   Parrish, Damon ^b   Polgar, Willma ^a   Toll, Lawrence ^a  

^a SRI INTERNATIONAL   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 7 [4 (2,6 DICHLOROPHENYL) 1 PIPERIDINYLMETHYL] 6,7,8,9 TETRAHYDRO 1 METHYL 5H BENZOCYCLOHEPTEN 5 OL; 8 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALEN 1 YL) 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE; INDOLE DERIVATIVE; N (4 AMINO 2 METHYL 6 QUINOLINYL) 2 (4 ETHYLPHENOXYMETHYL)BENZAMIDE; NOCICEPTIN RECEPTOR; PIPERIDIN 4 YL 1,3 DIHYDROINDOL 2 ONE; PIPERIDIN 4 YL 1,3 DIHYDROINDOL 2 ONE AGONIST; PIPERIDIN 4 YL 1,3 DIHYDROINDOL 2 ONE ANTAGONIST; PYRROLE DERIVATIVE; RO 64 65198; SPIRODECANONE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; HUMANS; INDOLES; LIGANDS; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2542609191     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034249d     Document Type: Article

References (28)

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28. See Supporting Information.