Determinants of sweetness in proteins: A topological approach

Journal of Molecular Recognition

Volumn 24, Issue 6, 2011, Pages 1033-1042

  Temussi, Piero Andrea ^a,b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

brazzein; docking; homology modeling; monellin; sweet proteins; Sweet taste

Indexed keywords

BRAZZEIN PROTEIN, PENTADIPLANDRA BRAZZEANA; CELL SURFACE RECEPTOR; MONELLIN PROTEIN, DIOSCOREOPHYLLUM CUMMINSII; PROTEIN; SWEETENING AGENT; VEGETABLE PROTEIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; PHYSIOLOGY; PROTEIN CONFORMATION; TASTE;

ANIMALS; MODELS, MOLECULAR; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEINS; RECEPTORS, CELL SURFACE; SWEETENING AGENTS; TASTE;

DIONAEA; MAMMALIA;

EID: 80054786032     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.1152     Document Type: Article

References (29)

1. Assadi-Porter FM, Maillet EL, Radek JT, Quijada J, Markley JL, Max M,. 2010. Key Amino Acid Residues Involved in Multi-Point Binding Interactions between Brazzein a Sweet Protein and the T1R2-T1R3 Human Sweet Receptor. J. Mol. Biol. 398: 584-599.
2. Blake JD, Cohen FE,. 2001. Pairwise sequence alignment below the twilight zone. J. Mol. Biol. 307: 721-735. (Pubitemid 33027687)
3. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS,. 2006. The receptors and cells for mammalian taste. Nature 444: 288-294. (Pubitemid 44764097)
4. De Simone A, Spadaccini R, Temussi PA, Fraternali F,. 2006. MD calculations of MNEI a sweet protein: hot spots from hydration sites are consistent with key mutations and receptor interaction derived from docking calculations. Biophys. J. 90: 3052-3061.
5. Esposito V, Gallucci R, Picone D, Tancredi T, Temussi PA,. 2006. The Importance of Electrostatic Potential in the Interaction of sweet proteins with the sweet taste Receptor. J. Mol. Biol. 360: 448-456. (Pubitemid 43927834)
6. Guex N, Peitsch MC,. 1997. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modelling. Electrophoresis 18: 2714-2723. (Pubitemid 28059943)
7. Koradi R, Billeter M, Wüthrich K,. 1996. MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14: 29-32.
8. Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K,. 2000. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407: 971-977.
9. Lesk AM, Chothia C,. 1980. How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins. J. Mol. Biol. 136: 225-270.
10. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E,. 2002. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U.S.A. 99: 4692-4696. (Pubitemid 34286046)
11. Morini G, Bassoli A, Temussi PA,. 2005. From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2-T1R3 receptor. J. Med. Chem. 48: 5520-5229.
12. Murzin AG,. 1993. Sweet-tasting protein monellin is related to the cystatin family of thiol proteinase inhibitors. J. Mol. Biol. 230: 689-694. (Pubitemid 23161379)
13. Muto T, Tsuchiya D, Morikawa K, Jingami H,. 2007. Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc. Natl. Acad. Sci. U.S.A. 104: 3759-3764. (Pubitemid 47189144)
14. Niccolai N, Spadaccini R, Scarselli M, Bernini A, Crescenzi O, Spiga F, Ciutti A, Temussi PA,. 2001. Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe. Protein Sci. 10: 1498-1507. (Pubitemid 32667044)
15. Ohta K, Masuda T, Ide N, Kitabatake N,. 2008. Critical molecular regions for elicitation of the sweetness of the sweet-tasting protein thaumatin I. FEBS J. 275: 3644-3652.
16. Pastore A, Lesk AM,. 1990. Comparison of the structures of globins and phycocyanins: evidence for evolutionary relationship. Proteins: structure function and genetics 8, 133-155. (Pubitemid 20262538)
17. Peitsch MC,. 1995. Protein modelling by E-Mail. Bio/Technology 13: 658-660.
18. Peitsch MC,. 1996. ProMod and Swiss-Model: internet-based tools for automated comparative protein modelling. Biochem. Soc. Trans. 24: 274-279. (Pubitemid 26052435)
19. Somoza JR, Cho JM, Kim SH,. 1995. The taste-active regions of monellin a potently sweet protein. Chem. Senses 20: 61-68.
20. Spadaccini R, Crescenzi O, Tancredi T, De Casamassimi N, Saviano G, Scognamiglio R, Di Donato A, Temussi PA,. 2001. Solution structure of a sweet protein: nmr study of mnei a single chain monellin. J. Mol. Biol. 305: 505-514. (Pubitemid 33032857)
21. Spadaccini R, Trabucco F, Saviano G, Picone D, Crescenzi O, Tancredi T, Temussi PA,. 2003. The Mechanism of Interaction of Sweet Proteins with the T1R2-T1R3 Receptor: Evidence from the Solution Structure of G16A-MNEI. J. Mol. Biol. 328: 683-692. (Pubitemid 36438581)
22. Tancredi T, Pastore A, Salvadori S, Esposito V, Temussi PA,. 2004. Interaction of sweet proteins with their receptor A conformational study of peptides corresponding to loops of brazzein monellin and thaumatin. Eur. J. Biochem. 271: 2231-2240. (Pubitemid 38747992)
23. Temussi PA,. 2002. Why are sweet proteins sweet? Interaction of brazzein monellin and thaumatin with the T1R2-T1R3 receptor. FEBS Lett. 526: 1-4. (Pubitemid 35245681)
24. Temussi PA,. Natural Sweet Macromolecules: how Sweet Proteins work. 2006. Cell. Mol. Life Sci. 63: 1876-1888.
25. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG,. 1997. The CLUSTAL-X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 24: 4876-4882.
26. Vakser IA, Matar OG, Lam CF,. 1999. A systematic study of low-resolution recognition in protein-protein complexes. Proc. Natl. Acad. Sci. U.S.A. 96: 8477-8482. (Pubitemid 29354816)
27. Vakser IA,. 1995. Protein docking for low-resolution structures. Protein Eng. 8: 371-377.
28. Walters DE, Hellekant G,. 2006. Interactions of the Sweet Protein Brazzein with the Sweet Taste Receptor. J. Agric. Food Chem. 54: 10129-10133. (Pubitemid 46159019)
29. Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X,. 2004. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. U.S.A. 101: 14258-14263. (Pubitemid 39305062)