메뉴 건너뛰기




Volumn 31, Issue 10, 2011, Pages 3171-3180

Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: The role of human equilibrative nucleoside transporter 1

Author keywords

Cytotoxicity; Gemcitabine; hENT1; I3C; Pancreatic cancer

Indexed keywords

3 INDOLEMETHANOL; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; GEMCITABINE;

EID: 80054749399     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (50)
  • 1
    • 0037103069 scopus 로고    scopus 로고
    • New applications of gemcitabine and future directions in the management of pancreatic cancer
    • Abbruzzese JL: New applications of gemcitabine and future directions in the management of pancreatic cancer. Cancer 95: 941-945, 2002.
    • (2002) Cancer , vol.95 , pp. 941-945
    • Abbruzzese, J.L.1
  • 2
    • 73349119074 scopus 로고    scopus 로고
    • The convergence of lung cancer rates between blacks and whites under the age of 40, United States
    • Jemal A, Center MM and Ward E: The convergence of lung cancer rates between blacks and whites under the age of 40, United States. Cancer Epidemiol Biomarkers Prev 18: 3349-3352, 2009.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 3349-3352
    • Jemal, A.1    Center, M.M.2    Ward, E.3
  • 3
    • 0034994444 scopus 로고    scopus 로고
    • Nucleoside analogues: Mechanisms of drug resistance and reversal strategies
    • DOI 10.1038/sj.leu.2402114
    • Galmarini CM, Mackey JR and Dumontet C: Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 15: 875-890, 2001. (Pubitemid 32529886)
    • (2001) Leukemia , vol.15 , Issue.6 , pp. 875-890
    • Galmarini, C.M.1    Mackey, J.R.2    Dumontet, C.3
  • 4
    • 0037085269 scopus 로고    scopus 로고
    • Phosphorylation of pyrimidine deoxynucleoside analog diphosphates. Selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase
    • DOI 10.1074/jbc.M109025200
    • Krishnan P, Fu Q, Lam W, Liou JY, Dutschman G and Cheng YC: Phosphorylation of pyrimidine deoxynucleoside analog diphosphates: selective phosphorylation of L-nucleoside analog diphosphates by 3-phosphoglycerate kinase. J Biol Chem 277: 5453-5459, 2002. (Pubitemid 34968594)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 5453-5459
    • Krishnan, P.1    Fu, Q.2    Lam, W.3    Liou, J.-Y.4    Dutschman, G.5    Cheng, Y.-C.6
  • 5
    • 0037086275 scopus 로고    scopus 로고
    • Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates
    • Liou JY, Dutschman GE, Lam W, Jiang Z and Cheng YC: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res 62: 1624-1631, 2002. (Pubitemid 34408481)
    • (2002) Cancer Research , vol.62 , Issue.6 , pp. 1624-1631
    • Liou, J.-Y.1    Dutschman, G.E.2    Lam, W.3    Jiang, Z.4    Cheng, Y.-C.5
  • 8
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M and Buckels JA: A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 87: 161-167, 2002.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 9
    • 42949098425 scopus 로고    scopus 로고
    • Optimal second line treatment options for gemcitabine refractory advanced pancreatic cancer patients. Can we establish standard of care with available data?
    • Kang SP and Saif MW: Optimal second line treatment options for gemcitabine refractory advanced pancreatic cancer patients. Can we establish standard of care with available data? JOP 9: 83-90, 2008. (Pubitemid 351611723)
    • (2008) Journal of the Pancreas , vol.9 , Issue.2 , pp. 83-90
    • Kang, S.P.1    Saif, M.W.2
  • 11
    • 14944365541 scopus 로고    scopus 로고
    • Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells
    • DOI 10.1093/jb/mvh180
    • Takagaki K, Katsuma S, Kaminishi Y, Horio T, Nakagawa S, Tanaka T, Ohgi T and Yano J: Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells. J Biochem 136: 733-740, 2004. (Pubitemid 40364197)
    • (2004) Journal of Biochemistry , vol.136 , Issue.5 , pp. 733-740
    • Takagaki, K.1    Katsuma, S.2    Kaminishi, Y.3    Horio, T.4    Nakagawa, S.5    Tanaka, T.6    Ohgi, T.7    Yano, J.8
  • 12
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Seiner M, Mowles D, Young JD, Belt JA, Crawford CR and Cass CE: Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 58: 4349-4357, 1998. (Pubitemid 28450036)
    • (1998) Cancer Research , vol.58 , Issue.19 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3    Mowles, D.4    Young, J.D.5    Belt, J.A.6    Crawford, C.R.7    Cass, C.E.8
  • 13
    • 5044225419 scopus 로고    scopus 로고
    • Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
    • DOI 10.1111/j.1349-7006.2004.tb03257.x
    • Achiwa H, Oguri T, Sato S, Maeda H, Niimi T and Ueda R: Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 95: 753-757, 2004. (Pubitemid 39335096)
    • (2004) Cancer Science , vol.95 , Issue.9 , pp. 753-757
    • Achiwa, H.1    Oguri, T.2    Sato, S.3    Maeda, H.4    Niimi, T.5    Ueda, R.6
  • 14
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • DOI 10.1158/1078-0432.CCR-04-0224
    • Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, Cass C, Lai R and Mackey JR: The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 10: 6956-6961, 2004. (Pubitemid 39383046)
    • (2004) Clinical Cancer Research , vol.10 , Issue.20 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3    Dabbagh, L.4    Young, J.D.5    Dumontet, C.6    Cass, C.7    Lai, R.8    Mackey, J.R.9
  • 16
    • 74949112149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    • Okazaki T, Javle M, Tanaka M, Abbruzzese JL and Li D: Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Clin Cancer Res 16: 320-329, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 320-329
    • Okazaki, T.1    Javle, M.2    Tanaka, M.3    Abbruzzese, J.L.4    Li, D.5
  • 17
    • 34548580650 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
    • Mori R, Ishikawa T, Ichikawa Y, Taniguchi K, Matsuyama R, Ueda M, Fujii Y, Endo I, Togo S, Danenberg PV and Shimada H: Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep 17: 1201-1205, 2007.
    • (2007) Oncol Rep , vol.17 , pp. 1201-1205
    • Mori, R.1    Ishikawa, T.2    Ichikawa, Y.3    Taniguchi, K.4    Matsuyama, R.5    Ueda, M.6    Fujii, Y.7    Endo, I.8    Togo, S.9    Danenberg, P.V.10    Shimada, H.11
  • 18
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421, 2006.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 19
    • 0037469098 scopus 로고    scopus 로고
    • Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol
    • DOI 10.1016/S0304-3835(02)00550-5, PII S0304383502005505
    • Arora A and Shukla Y: Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol. Cancer Lett 189: 167-173, 2003. (Pubitemid 35461993)
    • (2003) Cancer Letters , vol.189 , Issue.2 , pp. 167-173
    • Arora, A.1    Shukla, Y.2
  • 20
    • 67650496175 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer
    • Banerjee S, Wang Z, Kong D and Sarkar FH: 3,3′-Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. Cancer Res 69: 5592-5600, 2009.
    • (2009) Cancer Res , vol.69 , pp. 5592-5600
    • Banerjee, S.1    Wang, Z.2    Kong, D.3    Sarkar, F.H.4
  • 21
    • 77955856301 scopus 로고    scopus 로고
    • Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents
    • Weng JR, Omar HA, Kulp SK and Chen CS: Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents. Mini Rev Med Chem 10: 398-404, 2010.
    • (2010) Mini Rev Med Chem , vol.10 , pp. 398-404
    • Weng, J.R.1    Omar, H.A.2    Kulp, S.K.3    Chen, C.S.4
  • 23
    • 1442277094 scopus 로고    scopus 로고
    • Modulation of the Constitutive Activated STAT3 Transcription Factor in Pancreatic Cancer Prevention: Effects of Indole-3-Carbinol (I3C) and Genistein
    • Lian JP, Word B, Taylor S, Hammons GJ and Lyn-Cook BD: Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. Anticancer Res 24: 133-137, 2004. (Pubitemid 38279698)
    • (2004) Anticancer Research , vol.24 , Issue.1 , pp. 133-137
    • Lian, J.P.1    Word, B.2    Taylor, S.3    Hammons, G.J.4    Lyn-Cook, B.D.5
  • 24
    • 78751474674 scopus 로고    scopus 로고
    • Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: Effect of indole-3-carbinol
    • Lyn-Cook BD, Mohammed SI, Davis C, Word B, Haefele A, Wang H and Hammons G: Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. Anticancer Res 30: 4907-4913, 2010.
    • (2010) Anticancer Res , vol.30 , pp. 4907-4913
    • Lyn-Cook, B.D.1    Mohammed, S.I.2    Davis, C.3    Word, B.4    Haefele, A.5    Wang, H.6    Hammons, G.7
  • 25
    • 77953614022 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants
    • Rahimi M, Huang KL and Tang CK: 3,3′-Diindolylmethane (DIM) inhibits the growth and invasion of drug-resistant human cancer cells expressing EGFR mutants. Cancer Lett 295: 59-68, 2010.
    • (2010) Cancer Lett , vol.295 , pp. 59-68
    • Rahimi, M.1    Huang, K.L.2    Tang, C.K.3
  • 26
    • 33750541268 scopus 로고    scopus 로고
    • Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-06-2011
    • Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S and Sarkar FH: Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res 66: 10064-10072, 2006. (Pubitemid 44672060)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10064-10072
    • Bhuiyan, M.M.R.1    Li, Y.2    Banerjee, S.3    Ahmed, F.4    Wang, Z.5    Ali, S.6    Sarkar, F.H.7
  • 27
    • 40649107590 scopus 로고    scopus 로고
    • Indole-3-carbinol as a chemopreventive and anti-cancer agent
    • Weng JR, Tsai CH, Kulp SK and Chen CS: Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett 262: 153-163, 2008.
    • (2008) Cancer Lett , vol.262 , pp. 153-163
    • Weng, J.R.1    Tsai, C.H.2    Kulp, S.K.3    Chen, C.S.4
  • 28
    • 77951718562 scopus 로고    scopus 로고
    • Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer
    • Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA and Sarkar FH: Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J Cell Biochem 110: 171-181, 2010.
    • (2010) J Cell Biochem , vol.110 , pp. 171-181
    • Ali, S.1    Banerjee, S.2    Schaffert, J.M.3    El-Rayes, B.F.4    Philip, P.A.5    Sarkar, F.H.6
  • 29
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • DOI 10.1158/0008-5472.CAN-07-2460
    • Fuchs BC, Fujii T, Dorfman JD, Goodwin JM, Zhu AX, Lanuti M and Tanabe KK: Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 68: 2391-2399, 2008. (Pubitemid 351521814)
    • (2008) Cancer Research , vol.68 , Issue.7 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3    Goodwin, J.M.4    Zhu, A.X.5    Lanuti, M.6    Tanabe, K.K.7
  • 31
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li Y, VandenBoom TG, 2nd, Kong D, Wang Z, Ali S, Philip PA and Sarkar FH: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 69: 6704-6712, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6704-6712
    • Li, Y.1    VandenBoom II, T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6    Sarkar, F.H.7
  • 33
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A and Remesy C: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S, 2005.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 34
    • 34548845889 scopus 로고    scopus 로고
    • Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines
    • DOI 10.1080/07357900701359577, PII 782019629
    • Lev-Ari S, Vexler A, Starr A, Ashkenazy-Voghera M, Greif J, Aderka D and Ben-Yosef R: Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Invest 25: 411-418, 2007. (Pubitemid 47450667)
    • (2007) Cancer Investigation , vol.25 , Issue.6 , pp. 411-418
    • Lev-Ari, S.1    Vexler, A.2    Starr, A.3    Ashkenazy-Voghera, M.4    Greif, J.5    Aderka, D.6    Ben-Yosef, R.7
  • 35
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • DOI 10.1038/sj.bjc.6603559, PII 6603559
    • Nakano Y, Tanno S, Koizumi K, Nishikawa T, Nakamura K, Minoguchi M, Izawa T, Mizukami Y, Okumura T and Kohgo Y: Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 96: 457-463, 2007. (Pubitemid 46215217)
    • (2007) British Journal of Cancer , vol.96 , Issue.3 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3    Nishikawa, T.4    Nakamura, K.5    Minoguchi, M.6    Izawa, T.7    Mizukami, Y.8    Okumura, T.9    Kohgo, Y.10
  • 38
    • 30344439138 scopus 로고    scopus 로고
    • Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy
    • DOI 10.1158/1535-7163.MCT-05-0065
    • Ali S, El-Rayes BF, Sarkar FH and Philip PA: Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther 4: 1943-1951, 2005. (Pubitemid 43056977)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.12 , pp. 1943-1951
    • Ali, S.1    El-Rayes, B.F.2    Sarkar, F.H.3    Philip, P.A.4
  • 40
    • 0030986972 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta
    • Douglas RS, Capocasale RJ, Lamb RJ, Nowell PC and Moore JS: Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. Blood 89: 941-947, 1997. (Pubitemid 27121287)
    • (1997) Blood , vol.89 , Issue.3 , pp. 941-947
    • Douglas, R.S.1    Capocasale, R.J.2    Lamb, R.J.3    Nowell, P.C.4    Moore, J.S.5
  • 41
    • 0035164289 scopus 로고    scopus 로고
    • Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells
    • DOI 10.1128/MCB.21.2.575-594.2001
    • Reeves R, Edberg DD and Li Y: Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 21: 575-594, 2001. (Pubitemid 32037376)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.2 , pp. 575-594
    • Reeves, R.1    Edberg, D.D.2    Li, Y.3
  • 42
    • 0031892133 scopus 로고    scopus 로고
    • Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies (Review)
    • Rabbani SA and Xing RH: Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies. Int J Oncol 12: 911-920, 1998. (Pubitemid 28133587)
    • (1998) International Journal of Oncology , vol.12 , Issue.4 , pp. 911-920
    • Rabbani, S.A.1    Xing, R.H.2
  • 43
    • 0037093087 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray
    • Han H, Bearss DJ, Browne LW, Calaluce R, Nagle RB and Von Hoff DD: Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Cancer Res 62: 2890-2896, 2002. (Pubitemid 34525776)
    • (2002) Cancer Research , vol.62 , Issue.10 , pp. 2890-2896
    • Han, H.1    Bearss, D.J.2    Browne, L.W.3    Calaluce, R.4    Nagle, R.B.5    Von Hoff, D.D.6
  • 44
    • 0031714080 scopus 로고    scopus 로고
    • Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
    • DOI 10.1038/2496
    • Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR and Sen S: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20: 189-193, 1998. (Pubitemid 28455454)
    • (1998) Nature Genetics , vol.20 , Issue.2 , pp. 189-193
    • Zhou, H.1    Kuang, J.2    Zhong, L.3    Kuo, W.-L.4    Gray, J.W.5    Sahin, A.6    Brinkley, B.R.7    Sen, S.8
  • 46
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside Transporter Profiles in Human Pancreatic Cancer Cells: Role of hCNT1 in 2′,2′-Difluorodeoxycytidine-Induced Cytotoxicity
    • Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A and Pastor-Anglada M: Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2′-difluorodeoxycytidine- induced cytotoxicity. Clin Cancer Res 9: 5000-5008, 2003. (Pubitemid 37323307)
    • (2003) Clinical Cancer Research , vol.9 , Issue.13 , pp. 5000-5008
    • Garcia-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3    Mazo, A.4    Pastor-Anglada, M.5
  • 47
    • 0033520708 scopus 로고    scopus 로고
    • Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters
    • Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE and Young JD: Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 91: 1876-1881, 1999.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1876-1881
    • Mackey, J.R.1    Yao, S.Y.2    Smith, K.M.3    Karpinski, E.4    Baldwin, S.A.5    Cass, C.E.6    Young, J.D.7
  • 48
    • 77956868652 scopus 로고    scopus 로고
    • Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells
    • Hagmann W, Jesnowski R and Lohr JM: Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia 12: 740-747, 2010.
    • (2010) Neoplasia , vol.12 , pp. 740-747
    • Hagmann, W.1    Jesnowski, R.2    Lohr, J.M.3
  • 49
    • 40749144013 scopus 로고    scopus 로고
    • Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer
    • DOI 10.1093/jjco/hym171
    • Masumori N, Kunishima Y, Hirobe M, Takeuchi M, Takayanagi A, Tsukamoto T and Itoh T: Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer. Jpn J Clin Oncol 38: 182-185, 2008. (Pubitemid 351419741)
    • (2008) Japanese Journal of Clinical Oncology , vol.38 , Issue.3 , pp. 182-185
    • Masumori, N.1    Kunishima, Y.2    Hirobe, M.3    Takeuchi, M.4    Takayanagi, A.5    Tsukamoto, T.6    Itoh, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.