메뉴 건너뛰기




Volumn 30, Issue 12, 2010, Pages 4907-4914

Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: Effect of indole-3-carbinol

Author keywords

Gemcitabine; Indole 3 carbinol; Pancreatic cancer; Sex differences

Indexed keywords

3 INDOLEMETHANOL; AZACITIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GEMCITABINE;

EID: 78751474674     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (12)

References (42)
  • 1
    • 67650924582 scopus 로고    scopus 로고
    • Pancreatic cancer: Molecular pathogenesis and new therapeutic targets
    • Wong HH and Lemoine NR: Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol 6: 412-422, 2009.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 412-422
    • Wong, H.H.1    Lemoine, N.R.2
  • 4
    • 23844517889 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor Rl 15777 in pancreatic cancer: A Southwest Oncology Group (SW)G 9924 study
    • Macdonald JS, McCoy S, Whitehead RP, Iqbal S, Wade JL 3rd, Giguere JK and Abbruzzese JL: A phase II study of farnesyl transferase inhibitor Rl 15777 in pancreatic cancer: a Southwest Oncology Group (SW)G 9924) study. Invest New Drugs 23: 485-487, 2005.
    • (2005) Invest New Drugs , vol.23 , pp. 485-487
    • Macdonald, J.S.1    McCoy, S.2    Whitehead, R.P.3    Iqbal, S.4    Wade III, J.L.5    Giguere, J.K.6    Abbruzzese, J.L.7
  • 5
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first line therapy for patients with unresectable pancreatic cancer: A randomized trail
    • Bramhall SF, Rosemurgy A, Brown PD, Bowry C and Buckels JAC: Marimastat as first line therapy for patients with unresectable pancreatic cancer: a randomized trail. J Clin Oncol 19:3447-3454, 2001.
    • (2001) J Clin Oncol , vol.19 , pp. 3447-3454
    • Bramhall, S.F.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.C.5
  • 6
    • 0038308387 scopus 로고    scopus 로고
    • Drug development in pancreatic cancer: Finally, biology begets therapy
    • Cohen SJ and Meropol NJ: Drug development in pancreatic cancer: finally, biology begets therapy. Int J Gastrointest Cancer 32; 91-106, 2002.
    • (2002) Int J Gastrointest Cancer , vol.32 , pp. 91-106
    • Cohen, S.J.1    Meropol, N.J.2
  • 7
    • 67349117952 scopus 로고    scopus 로고
    • Treatment of advanced pancreatic cancer: From gemcitabine single agent to combinations and targeted therapy
    • Rivera F, Lopez-Tarruella S, Vega-Villega ME and Salcedo M: Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy. Cancer Retreatment Rev 35: 335-339, 2009.
    • (2009) Cancer Retreatment Rev , vol.35 , pp. 335-339
    • Rivera, F.1    Lopez-Tarruella, S.2    Vega-Villega, M.E.3    Salcedo, M.4
  • 8
    • 34248573808 scopus 로고    scopus 로고
    • Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappa-B-regulated gene products
    • Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J and Aggarwal BB: Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappa-B-regulated gene products. Cancer Res 67: 3853-3861, 2007.
    • (2007) Cancer Res , vol.67 , pp. 3853-3861
    • Kunnumakkara, A.B.1    Guha, S.2    Krishnan, S.3    Diagaradjane, P.4    Gelovani, J.5    Aggarwal, B.B.6
  • 11
    • 0037971286 scopus 로고    scopus 로고
    • Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
    • Rahman KM, Aranha FH, and Sarkar FH: Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells. Nutr Cancer 45: 101-112, 2003.
    • (2003) Nutr Cancer , vol.45 , pp. 101-112
    • Rahman, K.M.1    Aranha, F.H.2    Sarkar, F.H.3
  • 12
    • 0036262718 scopus 로고    scopus 로고
    • Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol
    • Frydoonfar HR, McGrath DR and Spigelman AD: Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol. Colorectal Dis 4: 205-207, 2002.
    • (2002) Colorectal Dis , vol.4 , pp. 205-207
    • Frydoonfar, H.R.1    McGrath, D.R.2    Spigelman, A.D.3
  • 13
    • 0038402729 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells
    • Nachshon-Kedmi M, Yannai S, Haj A and Fares FA: Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 41: 745-752, 2003.
    • (2003) Food Chem Toxicol , vol.41 , pp. 745-752
    • Nachshon-Kedmi, M.1    Yannai, S.2    Haj, A.3    Fares, F.A.4
  • 14
    • 0025776365 scopus 로고
    • Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
    • Bradlow HL, Michniviez J, Telang NT and Osborne MP: Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12: 1571-1574,1991.
    • (1991) Carcinogenesis , vol.12 , pp. 1571-1574
    • Bradlow, H.L.1    Michniviez, J.2    Telang, N.T.3    Osborne, M.P.4
  • 15
    • 0033964256 scopus 로고    scopus 로고
    • Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methy1-6- phenylimidazo [4,5-b]pyridine (PhIP) carcinogenesis: Inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochromome P450 in females F344 rats
    • He YH, Friesen MD, Ruch RJ and Schut HA: Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methy1-6-phenylimidazo [4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochromome P450 in females F344 rats. Food Chem Toxicol 55: 15-23, 2000.
    • (2000) Food Chem Toxicol , vol.55 , pp. 15-23
    • He, Y.H.1    Friesen, M.D.2    Ruch, R.J.3    Schut, H.A.4
  • 16
    • 0018137952 scopus 로고
    • Inhibition of polycyclic aromatic hydrocarbon- Induced neoplasia by naturally occurring indoles
    • Wattenberg LW and Loub WD: Inhibition of polycyclic aromatic hydrocarbon- induced neoplasia by naturally occurring indoles. Cancer Res 38: 1 410-1413, 1978.
    • (1978) Cancer Res , vol.38 , Issue.1 , pp. 410-1413
    • Wattenberg, L.W.1    Loub, W.D.2
  • 17
    • 0021738060 scopus 로고
    • Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione 5-transferase and epoxide hydrolase activities in the rat
    • Bradfield CA and Bjeldanes LF: Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione 5-transferase and epoxide hydrolase activities in the rat. Food Chem Toxicol 22: 977-982, 1984.
    • (1984) Food Chem Toxicol , vol.22 , pp. 977-982
    • Bradfield, C.A.1    Bjeldanes, L.F.2
  • 18
    • 0029959032 scopus 로고    scopus 로고
    • Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells
    • DOI 10.1016/0006-2952(96)00060-3
    • Chen I, Safe S and Bjeldanes LF: Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. Biochem Pharmacol 51: 1069-1076, 1996. (Pubitemid 26104627)
    • (1996) Biochemical Pharmacology , vol.51 , Issue.8 , pp. 1069-1076
    • Chen, I.1    Safe, S.2    Bjeldanes, L.3
  • 19
    • 0037662260 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3-3′-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter Sp 1 transcription factor interactions
    • Firestone GL and Bjeldanes LF: Indole-3-carbinol and 3-3′- diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter Sp 1 transcription factor interactions. J Nutr 133: 2448S-2455S, 2003.
    • (2003) J Nutr , vol.133
    • Firestone, G.L.1    Bjeldanes, L.F.2
  • 20
    • 34948907867 scopus 로고    scopus 로고
    • Indole-3-carbinol (I3C) modulates expression of DNA methyltransferases 1, 3a, and 3b in pancreatic cancer cells: Effects of gender and a novel (C→T) polymorphism in the promoter region of DNMT 3b
    • Haefele A, Word B, Yongmei, X, Hammons GJ and Lyn-Cook BD: Indole-3-carbinol (I3C) modulates expression of DNA methyltransferases 1, 3a, and 3b in pancreatic cancer cells: Effects of gender and a novel (C→T) polymorphism in the promoter region of DNMT 3b. Int J Cancer Prevention 2: 245-255, 2007.
    • (2007) Int J Cancer Prevention , vol.2 , pp. 245-255
    • Haefele, A.1    Word, B.2    Yongmei, X.3    Hammons, G.J.4    Lyn-Cook, B.D.5
  • 21
    • 0141995080 scopus 로고    scopus 로고
    • Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas
    • Girault I, Tozlu S, Lidereau R and Bieche I: Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 9: 4415-4422, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 4415-4422
    • Girault, I.1    Tozlu, S.2    Lidereau, R.3    Bieche, I.4
  • 22
    • 0035863455 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA methylation of CpG islands and pericentromeric satellite regions in human colorectal and stomach cancers
    • Kanai Y, Ushijima S, Kondo Y, Nakanishi Y and Hirohashi S: DNA methyltransferase expression and DNA methylation of CpG islands and pericentromeric satellite regions in human colorectal and stomach cancers. Int J Cancer 91: 205-212, 2001.
    • (2001) Int J Cancer , vol.91 , pp. 205-212
    • Kanai, Y.1    Ushijima, S.2    Kondo, Y.3    Nakanishi, Y.4    Hirohashi, S.5
  • 23
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA and Jones PA: The human DNA methyltransferases (DNMTs) 1, 3a, and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27: 2292-2298, 1999.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2292-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5    Gonzales, F.A.6    Jones, P.A.7
  • 24
    • 0027504621 scopus 로고
    • Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
    • Wu J, Issa JP, Herman J, Bassett DE Jr, Nelkin BD and Baylin SB: Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc Natl Acad Sci U.S.A. 90: 8891-8895,1993.
    • (1993) Proc Natl Acad Sci U.S.A. , vol.90 , pp. 8891-8895
    • Wu, J.1    Issa, J.P.2    Herman, J.3    Bassett Jr., D.E.4    Nelkin, B.D.5    Baylin, S.B.6
  • 25
    • 29244453281 scopus 로고    scopus 로고
    • Methylation of tumor suppressor genes p16(lNK4a), p27(Kipl), and E-cadherin in carcinogenesis
    • Auerkari EI: Methylation of tumor suppressor genes p16(lNK4a), p27(Kipl), and E-cadherin in carcinogenesis. Oral Oncol 42: 5-13, 2006.
    • (2006) Oral Oncol , vol.42 , pp. 5-13
    • Auerkari, E.I.1
  • 27
    • 31544471349 scopus 로고    scopus 로고
    • Curcumin synergistically potentiates the growth inhibitory and pro- Apoptotic effects of celecoxib in pancreatic adenocarcinoma cells
    • Lev-Ari, Zinger H, Kazanov D, Yona D, Ben-Yosef R, Starr A, Figer A and Arber N: Curcumin synergistically potentiates the growth inhibitory and pro- apoptotic effects of celecoxib in pancreatic adenocarcinoma cells. Biomed Pharmacother 59 (Suppl.2): S276-S280, 2005.
    • (2005) Biomed Pharmacother , vol.59 , Issue.SUPPL. 2
    • Lev-Ari, Z.H.1    Kazanov, D.2    Yona, D.3    Ben-Yosef, R.4    Starr, A.5    Figer, A.6    Arber, N.7
  • 28
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-KB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR and Chiao PJ: The nuclear factor-KB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 29
    • 33645064160 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-KB activity by genistein is mediated via Notch1 signaling pathway in pancreatic cancer cells
    • Wang Z, Zhang Y, Banerjee S, Li Y and Sarker FH: Inhibition of nuclear factor-KB activity by genistein is mediated via Notch1 signaling pathway in pancreatic cancer cells. Int J Cancer 118: 1930-1936, 2006.
    • (2006) Int J Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarker, F.H.5
  • 30
    • 33751264196 scopus 로고    scopus 로고
    • Potentiation of the effect of erlotnib by genistein in pancreatic cancer: The role of Akt and nuclear factor-KB
    • El-Rayes BF, Ali S, Ali IF, Philip PA, Abbruzzese J and Sarkar FH: Potentiation of the effect of erlotnib by genistein in pancreatic cancer: the role of Akt and nuclear factor-KB. Cancer Res 66: 10553-10559, 2006.
    • (2006) Cancer Res , vol.66 , pp. 10553-10559
    • El-Rayes, B.F.1    Ali, S.2    Ali, I.F.3    Philip, P.A.4    Abbruzzese, J.5    Sarkar, F.H.6
  • 31
    • 33645761199 scopus 로고    scopus 로고
    • The natural chemopreventive compound indole-3-carbinol: State of the science
    • Rogan EG: The natural chemopreventive compound indole-3-carbinol: state of the science. In vivo 20: 221-228, 2006.
    • (2006) Vivo , vol.20 , pp. 221-228
    • Rogan, E.G.1
  • 32
    • 78751488845 scopus 로고    scopus 로고
    • Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: Effects of indole-3-carbinol (I3C) and genistein
    • Lian JP, Word B, Taylor S, Hammons GJ and Lyn-Cook BD: Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein. Anticancer Res 23: 3-7, 2004.
    • (2004) Anticancer Res , vol.23 , pp. 3-7
    • Lian, J.P.1    Word, B.2    Taylor, S.3    Hammons, G.J.4    Lyn-Cook, B.D.5
  • 33
    • 0038018408 scopus 로고    scopus 로고
    • Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP
    • Jeon KI, Rih JK, Kim HJ, Lee YJ, Cho CH, Goldberg ID, Rosen EM and Bae I: Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. FEBS Lett 544: 246-251, 2003.
    • (2003) FEBS Lett , vol.544 , pp. 246-251
    • Jeon, K.I.1    Rih, J.K.2    Kim, H.J.3    Lee, Y.J.4    Cho, C.H.5    Goldberg, I.D.6    Rosen, E.M.7    Bae, I.8
  • 34
    • 0033559197 scopus 로고    scopus 로고
    • Indole-3-carbinol and tamoxifen cooperates to arrest the cell cycle of MCF-7 human breast cancer cells
    • Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF and Firestone GL: Indole-3-carbinol and tamoxifen cooperates to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 59: 1244-1251, 1999.
    • (1999) Cancer Res , vol.59 , pp. 1244-1251
    • Cover, C.M.1    Hsieh, S.J.2    Cram, E.J.3    Hong, C.4    Riby, J.E.5    Bjeldanes, L.F.6    Firestone, G.L.7
  • 37
    • 33745627069 scopus 로고    scopus 로고
    • DNA methylation of multiple tumor-related genes in association with the overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    • Peng D-F, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kitazawa S and Hirohashi S: DNA methylation of multiple tumor-related genes in association with the overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 27: 1160-1168, 2006.
    • (2006) Carcinogenesis , vol.27 , pp. 1160-1168
    • Peng, D.-F.1    Kanai, Y.2    Sawada, M.3    Ushijima, S.4    Hiraoka, N.5    Kitazawa, S.6    Hirohashi, S.7
  • 39
    • 33646407273 scopus 로고    scopus 로고
    • Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival
    • Sebastiani V, Ricci F, Rubio-Viqueira B, Kulesza P, Yeo CJ, Hidalgo M, Klein A, Laheru D and Iacobuzio-Donahue CA: Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res 12: 2492-2497, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 2492-2497
    • Sebastiani, V.1    Ricci, F.2    Rubio-Viqueira, B.3    Kulesza, P.4    Yeo, C.J.5    Hidalgo, M.6    Klein, A.7    Laheru, D.8    Iacobuzio-Donahue, C.A.9
  • 40
    • 0023203849 scopus 로고
    • Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/ and CCRF/CEM/ddCK-1
    • Antonsson BE, Avramis VI, Nyce J and Holcenberg JS: Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/) and CCRF/CEM/ddCK-1. Cancer Res 47: 3672-3678, 1987.
    • (1987) Cancer Res , vol.47 , pp. 3672-3678
    • Antonsson, B.E.1    Avramis, V.I.2    Nyce, J.3    Holcenberg, J.S.4
  • 41
    • 0015977654 scopus 로고
    • Purification and properties of cytidine deaminase from normal and leukemic granulocytes
    • Chabner BA, Johns DG, Coleman CN, Drake JC and Evans WH: Purification and properties of cytidine deaminase from normal and leukemic granulocytes. J Clin Invest 53: 287-290, 1974.
    • (1974) J Clin Invest , vol.53 , pp. 287-290
    • Chabner, B.A.1    Johns, D.G.2    Coleman, C.N.3    Drake, J.C.4    Evans, W.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.