Intact nanoparticulate indomethacin in fast-dissolving carrier particles by combined wet milling and aerosol flow reactor methods

Pharmaceutical Research

Volumn 28, Issue 10, 2011, Pages 2403-2411

  Laaksonen, Timo ^a   Liu, Peng ^a   Rahikkala, Antti ^b   Peltonen, Leena ^a   Kauppinen, Esko I ^b   Hirvonen, Jouni ^a   Järvinen, Kristiina ^c   Raula, Janne ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b AALTO UNIVERSITY   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

aerosol flow reactor; drug dissolution; media milling; microparticles; nanoparticles

Indexed keywords

DRUG CARRIER; INDOMETACIN; LEUCINE; MANNITOL; MICROPARTICLE CARRIER; NANOCARRIER; POLOXAMER; UNCLASSIFIED DRUG;

AEROSOL FLOW REACTOR; AQUEOUS SOLUTION; ARTICLE; BIOREACTOR; CHEMICAL COMPOSITION; CHEMICAL PROCEDURES; CONTROLLED STUDY; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG COATING; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; WET MILLING; X RAY POWDER DIFFRACTION;

AEROSOLS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EXCIPIENTS; INDOMETHACIN; LEUCINE; MANNITOL; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POWDERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 80054749072     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0456-z     Document Type: Article

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