Kinetics and genomic profiling of adult human and mouse β-cell maturation

Islets

Volumn 3, Issue 4, 2011, Pages 175-187

  Szabat, Marta ^a   Pourghaderi, Poya ^a   Soukhatcheva, Galina ^b   Verchere, C Bruce ^a,b   Warnock, Garth L ^a   Piret, James M ^c   Johnson, James D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

cells; Human; Insulin; Islets; Maturation; Microarray; MIN6; Mouse; Pdx1

Indexed keywords

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEDIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; TISSUE REGENERATION;

ADULT; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; KINETICS; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; RATS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SINGLE-CELL ANALYSIS; TRANS-ACTIVATORS;

EID: 79960095521     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.3.4.15881     Document Type: Article

References (48)

1. Szabat M, Luciani DS, Piret JM, Johnson JD. Maturation of adult beta-cells revealed using a Pdx1/insulin dual-reporter lentivirus. Endocrinology 2009; 150:1627-35.
2. Szabat M, Johnson JD, Piret JM. Reciprocal modulation of adult beta cell maturity by activin A and follistatin. Diabetologia 2010; 53:1680-9.
3. Hill JA, Szabat M, Hoesli CA, Gage BK, Yang YH, Williams DE, et al. A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression. PLoS One 2010; 5:12958.
4. Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, et al. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol 2007; 7:92.
5. Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000; 127:1563-72. (Pubitemid 30234914)
6. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998; 12:1705-13. (Pubitemid 28299520)
7. Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994; 371:606-9. (Pubitemid 24315741)
8. + cells are islet progenitors and are distinct from duct progenitors. Development 2002; 129:2447-57.
9. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, et al. Notch signalling controls pancreatic cell differentiation. Nature 1999; 400:877-81. (Pubitemid 29406724)
10. Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia 2007; 50:2504-15. (Pubitemid 350060652)
11. Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci USA 2009; 106:9715-20.
12. +/- mice. J Clin Invest 2003; 111:1147-60.
13. Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, et al. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci USA 2006; 103:19575-80. (Pubitemid 46026072)
14. Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, et al. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev 2006; 20:253-66. (Pubitemid 43112942)
15. Lukinius A, Ericsson JL, Grimelius L, Korsgren O. Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones. Dev Biol 1992; 153:376-85.
16. Teitelman G, Alpert S, Polak JM, Martinez A, Hanahan D. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 1993; 118:1031-9. (Pubitemid 23252394)
17. Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, Vassalli JD. Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 1991; 113:1257-65.
18. Bocian-Sobkowska J, Zabel M, Wozniak W, Surdyk- Zasada J. Polyhormonal aspect of the endocrine cells of the human fetal pancreas. Histochem Cell Biol 1999; 112:147-53. (Pubitemid 29421924)
19. Chiang MK, Melton DA. Single-cell transcript analysis of pancreas development. Dev Cell 2003; 4:383-93. (Pubitemid 36342363)
20. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, et al. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia 2009; 53:128-38.
21. Pechhold K, Zhu X, Harrison VS, Lee J, Chakrabarty S, Koczwara K, et al. Dynamic changes in pancreatic endocrine cell abundance, distribution and function in antigen-induced and spontaneous autoimmune diabetes. Diabetes 2009; 58:1175-84.
22. Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 2004; 131:165-79. (Pubitemid 38111424)
23. Easom RA. CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis. Diabetes 1999; 48:675-84. (Pubitemid 29153064)
24. Duan L, Cobb MH. Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proc Natl Acad Sci USA 2010; 107:22314-9.
25. Lao G, Scheuss V, Gerwin CM, Su Q, Mochida S, Rettig J, et al. Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. Neuron 2000; 25:191-201. (Pubitemid 30316521)
26. Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, et al. Islet-1 is required for the maturation, proliferation and survival of the endocrine pancreas. Diabetes 2009; 58:2059-69.
27. Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, et al. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol 2008; 314:443-56.
28. Aye T, Toschi E, Sharma A, Sgroi D, Bonner-Weir S. Identification of markers for newly formed {beta} cells in the perinatal period: a time of recognized {beta} cell immaturity. J Histochem Cytochem 2010; 58:369-76.
29. Edlund H. Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nat Rev Genet 2002; 3:524-32. (Pubitemid 34746877)
30. Hegedus Z, Czibula A, Kiss-Toth E. Tribbles: a family of kinase-like proteins with potent signalling regulatory function. Cell Signal 2007; 19:238-50. (Pubitemid 44969976)
31. Prudente S, Morini E, Trischitta V. The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes. Acta Diabetol 2009; 46:79-84.
32. Savaskan NE, Brauer AU, Nitsch R. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur J Neurosci 2004; 19:212-20. (Pubitemid 38122087)
33. Bosse A, Zulch A, Becker MB, Torres M, Gomez-Skarmeta JL, Modolell J, et al. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev 1997; 69:169-81. (Pubitemid 28064955)
34. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72. (Pubitemid 350138099)
35. Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 2009; 17:62-74.
36. Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 2002; 129:2367-79. (Pubitemid 34863845)
37. Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S. Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One 2009; 4:6417.
38. Ait-Lounis A, Baas D, Barras E, Benadiba C, Charollais A, Nlend Nlend R, et al. Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas. Diabetes 2007; 56:950-9. (Pubitemid 46525062)
39. Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, et al. Rfx6 directs islet formation and insulin production in mice and humans. Nature 2010; 463:775-80.
40. Emery P, Strubin M, Hofmann K, Bucher P, Mach B, Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol Cell Biol 1996; 16:4486-94. (Pubitemid 26251250)
41. Okano H, Imai T, Okabe M. Musashi: a translational regulator of cell fate. J Cell Sci 2002; 115:1355-9. (Pubitemid 34428693)
42. Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, et al. Activin receptor patterning of foregut organogenesis. Genes Dev 2000; 14:1866-71. (Pubitemid 30639520)
43. Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P. Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn 2003; 226:663-74. (Pubitemid 36396875)
44. Yang YH, Szabat M, Bragagnini C, Kott K, Helgason CD, Hoffman BG, et al. Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors. Diabetologia 2011.
45. Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, et al. Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci USA 1993; 90:527-31. (Pubitemid 23028896)
46. van Haaften RI, Schroen B, Janssen BJ, van Erk A, Debets JJ, Smeets HJ, et al. Biologically relevant effects of mRNA amplification on gene expression profiles. BMC Bioinformatics 2006; 7:200.
47. Wang Z, Zhu T, Rehman KK, Bertera S, Zhang J, Chen C, et al. Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes 2006; 55:875-84. (Pubitemid 44100159)
48. Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, Bryan J. Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. PLoS Comput Biol 2006; 2:158.