Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Garcia, Analia E ^a   Mada, Sripal R ^a   Rico, Mario C ^a   DelaCadena, Raul A ^a   Kunapuli, Satya P ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; PEPTIDOGLYCAN POLYSACCHARIDE; THROMBOCYTE FACTOR 4; CYTOKINE; DRUG DERIVATIVE; PEPTIDOGLYCAN; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR; TICLOPIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BLOOD VESSEL; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HISTOLOGY; INFLAMMATION; NEUTROPHIL COUNT; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; THROMBOCYTE COUNT; TREATMENT OUTCOME; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; LEUKOCYTOSIS; METABOLISM; NEUTROPHIL; PATHOLOGY; THROMBOCYTE AGGREGATION; THROMBOCYTOSIS;

ANIMALIA; RATTUS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; FEMALE; INFLAMMATION; LEUKOCYTOSIS; NEUTROPHILS; PEPTIDOGLYCAN; PLATELET AGGREGATION; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2Y12; THROMBOCYTOSIS; TICLOPIDINE;

EID: 80054738924     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026035     Document Type: Article

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