Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis

Translational Research

Volumn 152, Issue 2, 2008, Pages 95-98

  Rico, Mario C ^a   Manns, Joanne M ^a   Driban, Jeffrey B ^a   Uknis, Audrey B ^a   Kunapuli, Satya P ^a   Dela Cadena, Raul A ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

EID: 50949097435     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2008.06.002     Document Type: Article

References (16)

1. Feldmann M., Brennan F.M., and Maini R.N. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14 (1996) 397-440
2. Koch A.E., Szekanecz Z., Friedman J., Haines G.K., Langman C.B., and Bouck N.P. Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis. Clin Immunol Immunopathol 86 (1998) 199-208
3. Gotis-Graham I., Hogg P.J., and McNeil H.P. Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium. Arthritis Rheum 40 (1997) 1780-1787
4. Manns J.M., Uknis A.B., Rico M.C., et al. A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor. Arthritis Rheum 54 (2006) 2415-2422
5. Pohlers D., Beyer A., Koczan D., Wilhelm T., Thiesen H.J., and Kinne R.W. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 9 (2007) R59
6. Rico M.C., Castaneda J.L., Manns J.M., et al. Amelioration of inflammation, angiogenesis and CTGF expression in an arthritis model by a TSP1-derived peptide treatment. J Cell Physiol 211 (2007) 504-512
7. Lawler J. The structural and functional properties of thrombospondin. Blood 67 (1986) 1197-1209
8. Schultz-Cherry S., and Murphy-Ullrich J.E. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol 122 (1993) 923-932
9. Cheon H., Yu S.J., Yoo D.H., Chae I.J., Song G.G., and Sohn J. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol 127 (2002) 547-552
10. Fava R., Olsen N., Keski-Oja J., Moses H., and Pincus T. Active and latent forms of transforming growth factor beta activity in synovial effusions. J Exp Med 169 (1989) 291-296
11. Schweitzer B., Roberts S., Grimwade B., et al. Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat Biotechnol 20 (2002) 359-365
12. de Jager W., Hoppenreijs E.P., Wulffraat N.M., Wedderburn L.R., Kuis W., and Prakken B.J. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis 66 (2007) 589-598
13. Stuhlmuller B., Ungethum U., Scholze S., et al. Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum 43 (2000) 775-790
14. Janabi M., Yamashita S., Hirano K., et al. Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients. Arterioscler Thromb Vasc Biol 20 (2000) 1953-1960
15. Aggarwal A., Agarwal S., and Misra R. Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA). Clin Exp Immunol 148 (2007) 515-519
16. Haas C.S., Amin M.A., Ruth J.H., et al. In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis. Arthritis Rheum 56 (2007) 2535-2548