Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6724-6727

  Ma, Kaiqing ^a   Wang, Penghui ^a   Fu, Wei ^a   Wan, Xiaolong ^b   Zhou, Lu ^a   Chu, Yong ^a   Ye, Deyong ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

HIV integrase; Inhibitors; Pharmacophore; Structure activity relationship (SAR)

Indexed keywords

2 PYRROLINONE; GSK 364735; INTEGRASE; INTEGRASE INHIBITOR; NUCLEOTIDYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; VIRUS REPLICATION;

DRUG DESIGN; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MODELS, MOLECULAR; PYRROLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80054728771     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.054     Document Type: Article

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