Limits for antibody affinity maturation and repertoire diversification in hypervaccinated humans

Journal of Immunology

Volumn 187, Issue 8, 2011, Pages 4229-4235

  Poulsen, Tine Rugh ^a,b   Jensen, Allan ^a,c   Haurum, John S ^a,d   Andersen, Peter S ^a  

^a Symphogen AS   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETANUS TOXOID;

ADAPTIVE IMMUNITY; ADULT; ANTIBODY AFFINITY; ARTICLE; B LYMPHOCYTE; BINDING SITE; DISSOCIATION CONSTANT; ENVIRONMENTAL TEMPERATURE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE SYSTEM; IMMUNOLOGICAL PARAMETERS; IMMUNOREACTIVITY; INTERNALIZATION; KINETICS; LIMITS FOR ANTIBODY AFFINITY MATURATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPERTOIRE DIVERSIFICATION; SEQUENCE HOMOLOGY; SOMATIC MUTATION; UNINDEXED SEQUENCE; VACCINATION;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SURFACE PLASMON RESONANCE; TETANUS TOXOID; VACCINATION;

EID: 80054720191     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000928     Document Type: Article

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