Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous VH Genes

Journal of Molecular Biology

Volumn 387, Issue 3, 2009, Pages 548-558

  de Kruif, John ^a   Kramer, Arjen ^a   Visser, Therèse ^a   Clements, Carina ^a   Nijhuis, Roy ^a   Cox, Freek ^a   van der Zande, Vanessa ^a   Smit, Renate ^a   Pinto, Daniel ^a   Throsby, Mark ^a   Logtenberg, Ton ^a  

^a Merus Biopharmaceuticals   (Netherlands)

Author keywords

antibody; promiscuous; repertoire; tetanus; VH gene

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; REVAXIS; TETANUS TOXOID; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; GENETIC VARIABILITY; HUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

EID: 62049083031     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.02.009     Document Type: Article

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