Metoprolol impairs resistance artery function in mice

Journal of Applied Physiology

Volumn 111, Issue 4, 2011, Pages 1125-1133

  El Beheiry, Mostafa H ^a,b   Heximer, Scott P ^b,c   Voigtlaender Bolz, Julia ^a,c   Mazer, C David ^a,b,c   Connelly, Kim A ^a   Wilson, David F ^d   Beattie, W Scott ^e   Tsui, Albert K Y ^a,b   Zhang, Hangjun ^b   Golam, Kabir ^a   Hu, Tina ^a   Liu, Elaine ^a   Lidington, Darcy ^b,c   Bolz, Steffen Sebastian ^b,c   Hare, Gregory M T ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; METOPROLOL; OXYGEN;

ANIMAL; ARTICLE; BLOOD PRESSURE; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; DRUG EFFECT; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; MESENTERIC ARTERY; METABOLISM; MICROVASCULATURE; MOUSE; MUSCLE DEVELOPMENT; PHYSIOLOGY; POSTERIOR CEREBRAL ARTERY; VASCULAR RESISTANCE; VASCULARIZATION; VASODILATATION;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ANIMALS; BLOOD PRESSURE; BRAIN; CARDIAC OUTPUT; CEREBROVASCULAR CIRCULATION; HEART RATE; MESENTERIC ARTERIES; METOPROLOL; MICE; MICE, INBRED C57BL; MICROVESSELS; MUSCLE DEVELOPMENT; OXYGEN; POSTERIOR CEREBRAL ARTERY; RECEPTORS, ADRENERGIC, BETA-2; STROKE VOLUME; VASCULAR RESISTANCE; VASODILATION;

EID: 80054714995     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01340.2010     Document Type: Article

References (37)

1. Anonymous. Metoprolol in acute myocardial infarction (MIAMI). A randomised placebo-controlled international trial. The MIAMI Trial Research Group. Eur Heart J 6: 199-226, 1985.
2. Anonymous. Randomized.trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaborative Group. Lancet 2: 57-66, 1986.
3. Badgett RG, Lawrence VA, Cohn SL. Variations in pharmacology of beta-blockers may contribute to heterogeneous results in trials of perioperative beta-blockade. Anesthesiology 113: 585-592, 2010.
4. Bangalore S, Wetterslev J, Pranesh S, Sawhney S, Gluud C, Messerli FH. Perioperative beta blockers in patients having non-cardiac surgery: A meta-analysis. Lancet 372: 1962-1976, 2008.
5. Beattie WS, Karkouti K, Wijeysundera DN, Tait G. Risk associated with preoperative anemia in noncardiac surgery: A single-center cohort study. Anesthesiology 110: 574-581, 2009.
6. Beattie WS, Wijeysundera DN, Karkouti K, McCluskey S, Tait G, Mitsakakis N, Hare GM. Acute surgical anemia influences the cardioprotective effects of beta-blockade: A single-center, propensity-matched cohort study. Anesthesiology 112: 25-33, 2010.
7. Bolz SS, Vogel L, Sollinger D, Derwand R, Boer C, Pitson SM, Spiegel S, Pohl U. Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase. Circulation 108: 342-347, 2003. (Pubitemid 36899027)
8. Briones AM, Daly CJ, Jimenez-Altayo F, Martinez-Revelles S, Gonzalez JM, McGrath JC, Vila E. Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries. Br J Pharmacol 146: 679-691, 2005. (Pubitemid 41573619)
9. Brixius K, Bundkirchen A, Bolck B, Mehlhorn U, Schwinger RH. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol 133: 1330-1338, 2001. (Pubitemid 32783494)
10. Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Malaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): A randomised controlled trial. Lancet 371: 1839- 1847, 2008.
11. Ellenberger C, Tait G, Beattie WS. Chronic beta blockade is associated with a better outcome after elective noncardiac surgery than acute beta blockade: A single-center propensity-matched cohort study. Anesthesiology 114: 817-823, 2011.
12. Felding M, Jakobsen CJ, Cold GE, Davidsen B, Jensen K. The effect of metoprolol upon blood pressure, cerebral blood flow and oxygen consumption in patients subjected to craniotomy for cerebral tumours. Acta Anaesthesiol Scand 38: 271-275, 1994. (Pubitemid 24133398)
13. Gao F, de Beer VJ, Hoekstra M, Xiao C, Duncker DJ, Merkus D. Both 1- and 2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exercise. Am J Physiol Heart Circ Physiol 298: H921-H929, 2010.
14. Grayburn PA, Hillis LD. Cardiac events in patients undergoing noncardiac surgery: Shifting the paradigm from noninvasive risk stratification to therapy. Ann Intern Med 138: 506-511, 2003. (Pubitemid 38129030)
15. Hare GMT, Worrall JMA, Baker AJ, Liu E, Sikich N, Mazer CD. Beta 2 adrenergic antagonist inhibits cerebral cortical oxygen delivery after severe hemodilution in rats. Br J Anaesth 97: 617-623, 2006. (Pubitemid 44593855)
16. Hocht C, Di VC, Opezzo JA, Bramuglia GF, Taira CA. Pharmacokinetic- pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: A microdialysis study. Naunyn Schmiedebergs Arch Pharmacol 373: 310-318, 2006. (Pubitemid 43999782)
17. Hocht C, DiVerniero C, Opezzo JA, Taira CA. Applicability of microdialysis as a technique for pharmacokinetic-pharmacodynamic (PK-PD) modeling of antihypertensive beta-blockers. J Pharmacol Toxicol Methods 52: 244-250, 2005. (Pubitemid 41207200)
18. Hoefer J, Azam MA, Kroetsch JT, Poi HL, Momen MA, Voigtlaender- Bolz J, Scherer EQ, Meissner A, Bolz SS, Husain M. Sphingosine- 1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circ Res 107:923-33, 2010.
19. Jackevicius CA, Tu K, Filate WA, Brien SE, Tu JV. Trends in cardiovascular drug utilization and drug expenditures in Canada between 1996 and 2001. Can J Cardiol 19: 1359-1366, 2003. (Pubitemid 37536557)
20. Leape LL, Berwick DM, Bates DW. What practices will most improve safety? Evidence-based medicine meets patient safety. JAMA 288: 501-507, 2002. (Pubitemid 34787485)
21. Lidington D, Peter BF, Meissner A, Kroetsch JT, Pitson SM, Pohl U, Bolz SS. The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries. Arterioscler Thromb Vasc Biol 29: 1916-1922, 2009.
22. Mangano DT, Goldman L. Preoperative assessment of patients with known or suspected coronary disease. N Engl J Med 333: 1750-1756, 1995. (Pubitemid 26007128)
23. McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM. Increased expression of HIF-1α, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol 292: R403-R414, 2007. (Pubitemid 46089855)
24. Messerli FH, Bangalore S, Yao SS, Steinberg JS. Cardioprotection with beta-blockers: Myths, facts and Pascal's wager. J Intern Med 266: 232-241, 2009.
25. Poldermans D, Boersma E, Bax JJ, Thomson IR, van d V, Blankensteijn JD, Baars HF, Yo TI, Trocino G, Vigna C, Roelandt JR, van UH. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 341: 1789-1794, 1999.
26. Poldermans D, Schouten O, van LF, Hoeks SE, van d V, Stolker RJ, Fleisher LA. Perioperative strokes and beta-blockade. Anesthesiology 111: 940-945, 2009.
27. Ragoonanan TE, Beattie WS, Mazer CD, Tsui AK, Leong-Poi H, Wilson DF, Tait G, Yu J, Liu E, Noronha M, Dattani ND, Mitsakakis N, Hare GM. Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats. Anesthesiology 111: 988-1000, 2009.
28. Redelmeier D, Scales D, Kopp A. Beta blockers for elective surgery in elderly patients: Population based, retrospective cohort study. BMJ 331: 932, 2005.
29. Sharp CF, Gardiner SJ, Jensen BP, Roberts RL, Troughton RW, Lainchbury JG, Begg EJ. CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. Pharmacogenomics J 9: 175-184, 2009.
30. Smith JC, Paulson ES, Cook DB, Verber MD, Tian Q. Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: Implications for fMRI. J Neurosci Methods 191: 258-262, 2010.
31. Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97: 404-415, 2004. (Pubitemid 38802544)
32. van Bommel J, Trouwborst A, Schwarte L, Siegemund M, Ince C, Henny C. Intestinal and cerebral oxygenation during severe isovolemic hemodilution and subsequent hyperoxic ventilation in a pig model. Anesthesiology 97: 660-670, 2002. (Pubitemid 34977327)
33. van Klei WA, Bryson GL, Yang H, Forster AJ. Effect of beta-blocker prescription on the incidence of postoperative myocardial infarction after hip and knee arthroplasty. Anesthesiology 111: 717-724, 2009.
34. Wallace AW, Au S, Cason BA. Perioperative beta-blockade: Atenolol is associated with reduced mortality when compared to metoprolol. Anesthesiology 114: 824-836, 2011.
35. Yilmaz B, Asci A, Arslan S. Determination of metoprolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection. J Sep Sci 33: 1904-1908, 2010.
36. Yoon IS, Choi MK, Kim JS, Shim CK, Chung SJ, Kim DD. Pharmacokinetics and first-pass elimination of metoprolol in rats: Contribution of intestinal first-pass extraction to low bioavailability of metoprolol. Xenobiotica 41: 243-251, 2011.
37. Yuen DA, Connelly KA, Advani A, Liao C, Kuliszewski MA, Trogadis J, Thai K, Advani SL, Zhang Y, Kelly DJ, Leong-Poi H, Keating A, Marsden PA, Stewart DJ, Gilbert RE. Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism. PLos One 5: E9543, 2010.