Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: Single-molecule imaging analysis

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36460-36468

  Hibino, Kayo ^a   Shibata, Tatsuo ^a,b   Yanagida, Toshio ^c   Sako, Yasushi ^a  

^a RIKEN   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION KINETICS; CATALYTIC DOMAINS; CELL SIGNALING; CONFORMATIONAL CHANGE; CRITICAL FUNCTIONS; CYSTEINE-RICH DOMAINS; DISSOCIATION TIME; FUNCTIONAL DOMAINS; KINETIC MODELS; LIVING CELL; LIVING HELA CELLS; MEMBRANE COMPONENTS; RATE-LIMITING STEPS; SINGLE-MOLECULE IMAGING; TERNARY COMPLEX; WILD TYPES;

AMINO ACIDS; BINDING SITES; CELL MEMBRANES; CYTOLOGY; DISSOCIATION; ENZYMES; KINETICS; MEMBRANES; MOLECULES; PHOSPHORYLATION; PLASMAS; SIGNALING;

ACTIVATION ANALYSIS;

CYSTEINE; EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATE; MUTANT PROTEIN; PHOSPHOTRANSFERASE; RAF PROTEIN; RAS PROTEIN;

ARTICLE; BINDING SITE; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; CYSTEINE RICH DOMAIN; CYTOPLASM; ENZYME ACTIVATION; ENZYME KINETICS; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE STRUCTURE; MOLECULAR IMAGING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

CELL MEMBRANE; ENZYME ACTIVATION; HELA CELLS; HUMANS; KINETICS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; MUTATION; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS;

EID: 80054710442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.262675     Document Type: Article

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