Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRα(-/-) embryos

Development

Volumn 125, Issue 3, 1998, Pages 533-544

  Ruiz Lozano, Pilar ^a,b   Smith, Susan M ^c   Perkins, Guy ^d   Kubalak, Steven W ^a,b,g   Boss, Gerry R ^a   Sucov, Henry M ^e   Evans, Ronald M ^f   Chien, Kenneth R ^a,b,g  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

cDNA subtraction; Energy depletion; Heart; In situ hybridization; Mouse; Retinoids

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ADENOSINE TRIPHOSPHATE; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RETINOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDIOMYOPATHY; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DNA LIBRARY; ELECTRON TRANSPORT; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENERGY METABOLISM; ENZYME SUBUNIT; GENE ISOLATION; HEART DEVELOPMENT; HEART FAILURE; HETEROZYGOTE; IN SITU HYBRIDIZATION; MITOCHONDRION; MOLECULAR CLONING; MOUSE; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ACYL-COA DEHYDROGENASE; ACYL-COA DEHYDROGENASES; ADENOSINE TRIPHOSPHATE; ANIMALS; CARDIOMYOPATHY, DILATED; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ELECTRON TRANSPORT COMPLEX I; ENERGY METABOLISM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; GENES; HEART; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MYOCARDIUM; NADH, NADPH OXIDOREDUCTASES; RATS; RATS, MUTANT STRAINS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0031890356     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Arber, S., Hunter, J. J., Ross, J.Jr., Hongo, M., Sansig, G., Borg, J., Perriard, J-C., Chien, K. R. and Caroni, P. (1997). MLP-deficient mice exhibit a disruption of cardiac myofibrillar organization, dilated cardiomyopathy, and heart failure. Cell 88, 393-403.
2. Arizmendi, J. M., Sketel, J. M., Runswich, M. J., Fearnley, I. M. and Walker, J. E. (1992). Complementary cDNA sequences of two 14.5 kDa subunits of NADH:ubiqunone oxidoredusctase from bovine heart mitochondria. Completion of the primary structure of the complex? FEBS Lett. 313, 80-84.
3. Bouillet, P., Oulad-Abdelghani, M., Vacaire, S., Garnier, J. M., Schuhbaur, B., Dolle, P. and Chambon, P. (1995). Efficient cloning of cDNAs of retinoic acid responsive genes in P19 embryonal carcinoma cell and characterization of a novel mouse gene, stra1 (mouse LERK-2/Eplg2) Dev. Biol. 170, 420-433.
4. Bradford, M. (1976). A rapid and sensitive method for the quantitaion of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Brouillet, E., Hantraye, P., Ferrante, R.J., Dolan, R., Leroy-Willig, A., Kowall, N.W., and Flint-Beal, M. (1995). Chronic mitochondrial energy impairement produces selective striatal degeneration and abnormal choreiform movements in primates. Proc. natl. Acad. Sci. USA 92, 7105-7109.
6. Buono, P., Paolella, G., Mancini, F. P., Izzo, P. and Salvatore, F. (1988). The complete nucleotide sequence of the gene coding for the human aldolase C. Nucleic Acids Res. 16, 4733.
7. Chen, J., and Chien, K.R. (1997). Cardiac restricted gene targeting reveals an essential, non-cell autonomous role of RXRα in cardiac ventricular muscle morphogenesis. Submitted.
8. Chen, Z., Friedrich, G.A., Soriano, P. (1994). Transcriptional enhancer factor I disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 8, 2293-2301
9. Coates, P. M. (1992). Historical perspective of medium-chain acyl-CoA dehydrogenase deficiencies. In The Metabolic Basis of Inhereted Disease (ed. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle), pp 289-329. New York: McGraw-Hill.
10. Dersch H. and Zile M.H. (1993). Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids. Dev. Biol. 160, 424-433
11. Dickman, E. D., Thaller, C. and Smith, S. M. (1997). Temporally-regulated retinoic acid depeletion produces specific neural crest, ocular and nervous system defects. Development 124, 3111-3121
12. -/- mice. Proc. Natl. Acad. Sci. USA 92, 7386-7390.
13. Evans, R. M. (1988). The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
14. Fishman, M.C. and Chien, K. R. (1997). Fashioning the vertebrate heart: the earliest embryonic decisions. Development 124, 2099-2117.
15. Glass, C. K. (1994). Differential recognition of target genes by nuclear receptor monomers, dimers and heterodimers. Endocrinol. Rev. 15, 391-407.
16. Gobel, H.H., Heipertz, R., Scholz, W., Iqbal, K., and Tellez-Nagel, I. (1978). Juvenile Huntington chorea: clinical, ultrastructural and biochemical studies. Neurology 28, 23-31.
17. Green, S and Chambon, P. (1988). Nuclear receptors enhance our understanding of transcription regulation. Trends Genet. 4, 309-314.
18. Gruber, P. J., Kubalak, S. W., Pexieder, T., Sucov, H. M., Evans, R. M. and Chien, K. R. (1996). RXRα deficiency confers susceptibility for aortic sac, conotruncal, atrioventricularcushion, and ventricular muscle defects in mice. J. Clin. Invest. 98, 1332-1343.
19. Gulick, T., Cresci, S., Caira, T., Moore, D. D. and Kelly, D. P. (1991). The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA 91, 11012-11016.
20. Jaber, M., Koch, W.J., Rockman, H.A., Smith, B., Bood, R.A., Sulik, K., Ross, J.Jr, Lefkowitz, R.J., Caron, M.C. and Giros, B. (1996) Essential role of beta adrenergic receptor kinase in cardiac development and function. Proc. Natl. Acad. Sci. USA 93, 12974-12979.
21. Jiang, Y. and Evans, T. (1996). The Xenopus GATA-4,5,6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol. 174, 258-270.
22. Jonk, L. J., Jonge, M. E., Vervaat, J. M., Wissink, S. and Kruijer, W. (1994). Isolation and developmental expression of retinoic-acid induced genes. Dev. Biol. 161, 604-614.
23. Kastner, P., Grondona, J., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J. L., Dolle, P. and Chambon, P. (1994). Genetic analysis of RXRα developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78, 987-1003
24. Kastner, P., Mark, M. and Chambon, P. (1995). Nonsteroid nuclear receptors: What are the genetic studies telling us about their role in real life? Cell 83, 859-869.
25. Kastner, P., Mark, M., Ghysenlicck, N., Krezel, W., Dupe, V., Grondona, J. M. and Chambon, P. (1997). Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development 124, 313-326.
26. Kelly, D.P., Gordon, J.I., Alperts, R. and Strauss, A. W. (1989). The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. J. Biol. Chem. 264, 18921-18925.
27. Kelly, D. P. and Strauss, A. W. (1994). Inherited cardiomyopathies. New Engl. J. Med. 330, 913-919.
28. Kreldberg, J. A., Sartola, H., Loring, J. M., Maeda, M., Pelleder, J., Housman, D and Jaenkseh, R. (1993). WT-1 is required for early kidney development. Cell 74, 679-691
29. Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M. (1997). GATA-4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060.
30. Lee, R.Y., Luo, J., Evans. R.M., Giguere, V., Sucov, H.M. (1997). Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations. Circulation Res. 80, 757-764
31. Lemasters, J. J. and Hackenbrock, C. R. (1978.) Firefly luciferase assay for ATP production by mitochondria. Methods Enzymol. 57, 36-50.
32. Leone, T. C., Cresci, S., Carter, M. E., Zhang, Z., Lala, D. S., Strauss, A. W. and Kelly, D. P. (1995). The human medium chain Acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Spl binding sites. J. Biol. Chem. 270, 16308-16314.
33. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P. (1993). Nkx2.5, a novel murine homeobox expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.
34. Lok, S., Kuijper, J. L., Jelinek, L. J., Kramer, J. M., Whitmore, T. E., Sprecher, C. A., Mathewes, S., Grant, F. J., Biggs, S. H. and Rosenberg, G.B. (1994). The human glucagon receptor encoding gene : structure, cDNA sequence and chromosomal localization. Gene 140, 203-209.
35. Lyons, L., Parsons, L. M., Hartley, L., Andrews, J. E., Robb, L. and Harvey, R. P. (1995a). Myogenic and morphogenic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2.5. Genes Dev. 9, 1654-1656.
36. Lyons, G. E., Micales, B. K., Schwarz, J., Martin, J. F. and Olson, E. N. (1995b). Expression of Mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J. Neurosci. 15, 5727-5738.
37. MacNeil, D. J., Occi, J. L., Hey, P. J., Strader, C. D. and Graziano, M. P. (1994). Cloning and expression of a human glucagon receptor. Biochem. Biophys. Res. Commun. 198, 328-334.
38. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Shutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P. and Evans, R. M. (1996). The nuclear receptor superfamily: The second decade. Cell 83, 835-839.
39. Moens, C.B., Stanton, B.R., Parada, L.F. and Rossant, J. (1993). Detects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 119, 485-499.
40. Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N. (1997). Requirement of the trancription factor GATA-4 for heart tube formation and ventral morphogenesis. Genes Dev. 11, 1061-1072.
41. Murphy, A. M., Thompson, W. R., Peng, L. F. and Jones, L. (1997). Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Biochem. J. 322, 393-401.
42. Neely, J. R., Rovetto, M. J. and Oram, F. J. (1972). Myocardial utilization of carbohydrate and lipids. Prog. Cardiovasc. Dis. 15, 289-329.
43. Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K. (1997) Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy Circulation 96, 2190-2196
44. Noack, K., Zardoya, R. and Meyer, A. (1996). The complete mitochondrial DNA sequence of the bichir (Polypterus ornatipinnis), a basal ray-finned fish: ancient establishment of the consensus vertebrate gene order. Genetics 144, 1165-1180.
45. Ohnishi, T. (1993). NADH-Quinone oxidoreductase, the most complex Complex. J. Bioenergenics and Biomembranes 25, 325-329.
46. Pilkington, S. J., Arizmendi, J. M., Fearnley, I. M., Runswich, M. J., Skehel, J. M. and Walker, J. E. (1993). Structural organization of complex I from bovine mitochondria. Biochem. Society Transaction 21, 26-31.
47. Poole, D. C and Mathieu-Costello, O. (1996). Relationship between fiber capillarization and mitochondrial volume density in control and trained rat soleus and plantaris muscles. Microcirculation 3, 175-186.
48. Rossant, J. (1996). Mouse mutants and cardiac development: new molecular insights into cardiogenesis. Circ. Res. 78, 349-353.
49. Sack, M. N., Disch, D. L., Rockman, H. A. and Kelly, D. P. (1997). A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc. Natl. Acad. Sci. USA (in press).
50. Scarpulla, C.R. (1996). Nuclear respiratory factors and the pathways of nuclear-mitochondrial interaction. Trends Cardiovasc. Med. 6, 39-44.
51. Sato, Y., Imahashi, T and Kagimoto, A. (1967). Electron microscopic observation on a case of sideroblastic anemia. J. Electron Microscopy (Tokyo) 16, 283-284.
52. Satoh, T., Miyoshi, M., Sakamoto, K. and Iwamura, H. (1996). Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH:ubiquinone oxidoreductases. Biochem. Biophys. Acta 1273, 21-30.
53. Srivastava, D., Cerjesi, P. and Olson, E.N. (1995). New subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.
54. Srivastava, D., Thomas, T., Lin, Q., Kirby, M.L., Brown, D. and Olson, E. N. (1997). Regulation of cardiac mesodermal and neural crest development by the HLH transcription factor dHAND. Nat. Genetics 16, 154-160.
55. 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 89, 93-103.
56. Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. and Evans, R. M. (1994). RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 8, 1007-1018.
57. Usui, H., Falk, J. D., Dopazo, A., deLecea, L., Erlander, M. G. and Sutcliffe,J. G. (1994). Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction. J. Neurosci. 14, 4915-4926.
58. Walker, J.E., Skenel, J.M. and Buchanan, S.K. (1995). Structural analysis of NADH;ubiquinone oxidoreductase from bovine heart mitochondria. Methods Enzymol. 260, 14-34.
59. Wilson, J. G. and Warkany, J. (1949). Aortic-arch and cardiac abnormalities in the offspring of vitamin A deficient rats. Am. J. Anat. 85, 113-155.
60. Zhou, Q. Y., Quaife, C. J., and Palmiter, R. D. (1995). Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374, 640-643.
61. Zou, Y., Evans, S., Chen, J., Kuo, H-C., Harvey, R. P. and Chien, K. R. (1997). CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124, 793-804.