The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer

Structure

Volumn 19, Issue 10, 2011, Pages 1413-1423

  Trausch, Jeremiah J ^a   Ceres, Pablo ^a   Reyes, Francis E ^a   Batey, Robert T ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 DEAZAGUANINE; APTAMER; FOLINIC ACID; GUANINE DERIVATIVE; PTERIN; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ANALYTICAL PARAMETERS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; RIBOSWITCH; RNA BINDING; RNA STRUCTURE; STRUCTURE ANALYSIS; THERMODYNAMICS; TRANSCRIPTION TERMINATION; TURNOVER TIME;

APTAMERS, NUCLEOTIDE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; CALORIMETRY; FOLIC ACID; GENE EXPRESSION REGULATION, BACTERIAL; GUANINE; LEUCOVORIN; LIGANDS; MAGNESIUM; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RIBOSWITCH; RNA; S-ADENOSYLMETHIONINE; STREPTOCOCCUS MUTANS; TERMINATOR REGIONS, GENETIC; TETRAHYDROFOLATES; THERMODYNAMICS; TRANSCRIPTION, GENETIC;

FIRMICUTES;

EID: 80054074740     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.06.019     Document Type: Article

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