-
1
-
-
77649202326
-
Protein aggregation diseases: pathogenicity and therapeutic perspectives
-
Aguzzi A., O'Connor T. Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nat. Rev. Drug Discov. 2010, 9:237-248.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 237-248
-
-
Aguzzi, A.1
O'Connor, T.2
-
2
-
-
77951776829
-
Alzheimer's disease: strategies for disease modification
-
Citron M. Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 2010, 9:387-398.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 387-398
-
-
Citron, M.1
-
3
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
4
-
-
27644493692
-
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn S., Nimmrich V., Striebinger A., Krantz C., Keller P., Janson B., Bahr M., Schmidt M., Bitner R.S., Harlan J., Barlow E., Ebert U., Hillen H. Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 2005, 95:834-847.
-
(2005)
J. Neurochem.
, vol.95
, pp. 834-847
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
Krantz, C.4
Keller, P.5
Janson, B.6
Bahr, M.7
Schmidt, M.8
Bitner, R.S.9
Harlan, J.10
Barlow, E.11
Ebert, U.12
Hillen, H.13
-
5
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., Wals P., Zhang C., Finch C.E., Krafft G.A., Klein W.L. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. USA 1998, 95:6448-6453.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
6
-
-
0033932761
-
Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia
-
Singer M., Stidwill R.P., Nathan A., Gainer J.L. Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia. Crit. Care Med. 2000, 28:1968-1972.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 1968-1972
-
-
Singer, M.1
Stidwill, R.P.2
Nathan, A.3
Gainer, J.L.4
-
7
-
-
34247890129
-
Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties
-
Kanakis C.D., Tarantilis P.A., Tajmir-Riahi H.A., Polissiou M.G. Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties. J. Agric. Food Chem. 2007, 55:970-977.
-
(2007)
J. Agric. Food Chem.
, vol.55
, pp. 970-977
-
-
Kanakis, C.D.1
Tarantilis, P.A.2
Tajmir-Riahi, H.A.3
Polissiou, M.G.4
-
8
-
-
0016852683
-
The use of crocetin in experimental atherosclerosis
-
Gainer J.L., Jones J.R. The use of crocetin in experimental atherosclerosis. Experientia 1975, 31:548-549.
-
(1975)
Experientia
, vol.31
, pp. 548-549
-
-
Gainer, J.L.1
Jones, J.R.2
-
9
-
-
77957755920
-
Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells
-
Nam K.N., Park Y.M., Jung H.J., Lee J.Y., Min B.D., Park S.U., Jung W.S., Cho K.H., Park J.H., Kang I., Hong J.W., Lee E.H. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur. J. Pharmacol. 2010, 648:110-116.
-
(2010)
Eur. J. Pharmacol.
, vol.648
, pp. 110-116
-
-
Nam, K.N.1
Park, Y.M.2
Jung, H.J.3
Lee, J.Y.4
Min, B.D.5
Park, S.U.6
Jung, W.S.7
Cho, K.H.8
Park, J.H.9
Kang, I.10
Hong, J.W.11
Lee, E.H.12
-
10
-
-
25444434647
-
Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice
-
Asai A., Nakano T., Takahashi M., Nagao A. Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. J. Agric. Food Chem. 2005, 53:7302-7306.
-
(2005)
J. Agric. Food Chem.
, vol.53
, pp. 7302-7306
-
-
Asai, A.1
Nakano, T.2
Takahashi, M.3
Nagao, A.4
-
12
-
-
7644225312
-
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier
-
Deane R., Wu Z., Zlokovic B.V. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 2004, 35:2628-2631.
-
(2004)
Stroke
, vol.35
, pp. 2628-2631
-
-
Deane, R.1
Wu, Z.2
Zlokovic, B.V.3
-
13
-
-
78651245383
-
Stoichiometry and affinity of the human serum albumin-Alzheimer's Abeta peptide interactions
-
Milojevic J., Melacini G. Stoichiometry and affinity of the human serum albumin-Alzheimer's Abeta peptide interactions. Biophys. J. 2011, 100:183-192.
-
(2011)
Biophys. J.
, vol.100
, pp. 183-192
-
-
Milojevic, J.1
Melacini, G.2
-
14
-
-
78449245429
-
A strategy for designing a peptide probe for detection of beta-amyloid oligomers
-
Hu Y., Su B., Kim C.S., Hernandez M., Rostagno A., Ghiso J., Kim J.R. A strategy for designing a peptide probe for detection of beta-amyloid oligomers. Chembiochem 2010, 11:2409-2418.
-
(2010)
Chembiochem
, vol.11
, pp. 2409-2418
-
-
Hu, Y.1
Su, B.2
Kim, C.S.3
Hernandez, M.4
Rostagno, A.5
Ghiso, J.6
Kim, J.R.7
-
15
-
-
33749535361
-
Preparation of amyloid beta-protein for structural and functional studies
-
Teplow D.B. Preparation of amyloid beta-protein for structural and functional studies. Methods Enzymol. 2006, 413:20-33.
-
(2006)
Methods Enzymol.
, vol.413
, pp. 20-33
-
-
Teplow, D.B.1
-
16
-
-
0032849874
-
Quantification of beta-sheet amyloid fibril structures with thioflavin T
-
LeVine H. Quantification of beta-sheet amyloid fibril structures with thioflavin T. Methods Enzymol. 1999, 309:274-284.
-
(1999)
Methods Enzymol.
, vol.309
, pp. 274-284
-
-
LeVine, H.1
-
17
-
-
0018374688
-
A graphical correction procedure for inner filter effect in fluorescence quenching titrations
-
Mertens M.L., Kagi J.H. A graphical correction procedure for inner filter effect in fluorescence quenching titrations. Anal. Biochem. 1979, 96:448-455.
-
(1979)
Anal. Biochem.
, vol.96
, pp. 448-455
-
-
Mertens, M.L.1
Kagi, J.H.2
-
18
-
-
37049080392
-
Experimental correction for the inner-filter effect in fluorescence spectra
-
Kubista M., Sjoback R., Eriksson S., Albinsson B. Experimental correction for the inner-filter effect in fluorescence spectra. Analyst 1994, 119:417-419.
-
(1994)
Analyst
, vol.119
, pp. 417-419
-
-
Kubista, M.1
Sjoback, R.2
Eriksson, S.3
Albinsson, B.4
-
19
-
-
0017996882
-
Corrections for inner-filter effects in fluorescence quenching measurements via right-angle and front-surface illumination
-
Leese R.A., Wehry E.L. Corrections for inner-filter effects in fluorescence quenching measurements via right-angle and front-surface illumination. Anal. Chem. 1978, 50:1193-1197.
-
(1978)
Anal. Chem.
, vol.50
, pp. 1193-1197
-
-
Leese, R.A.1
Wehry, E.L.2
-
20
-
-
35148888521
-
Rapid determination of enzyme kinetics from fluorescence: overcoming the inner filter effect
-
Palmier M.O., Van Doren S.R. Rapid determination of enzyme kinetics from fluorescence: overcoming the inner filter effect. Anal. Biochem. 2007, 371:43-51.
-
(2007)
Anal. Biochem.
, vol.371
, pp. 43-51
-
-
Palmier, M.O.1
Van Doren, S.R.2
-
21
-
-
79955382682
-
Non-esterified fatty acids generate distinct low-molecular weight amyloid-beta (Abeta42) oligomers along pathway different from fibril formation
-
Kumar A., Bullard R.L., Patel P., Paslay L.C., Singh D., Bienkiewicz E.A., Morgan S.E., Rangachari V. Non-esterified fatty acids generate distinct low-molecular weight amyloid-beta (Abeta42) oligomers along pathway different from fibril formation. PLoS One 2011, 6:e18759.
-
(2011)
PLoS One
, vol.6
-
-
Kumar, A.1
Bullard, R.L.2
Patel, P.3
Paslay, L.C.4
Singh, D.5
Bienkiewicz, E.A.6
Morgan, S.E.7
Rangachari, V.8
-
22
-
-
41649107124
-
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide
-
Tew D.J., Bottomley S.P., Smith D.P., Ciccotosto G.D., Babon J., Hinds M.G., Masters C.L., Cappai R., Barnham K.J. Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys. J. 2008, 94:2752-2766.
-
(2008)
Biophys. J.
, vol.94
, pp. 2752-2766
-
-
Tew, D.J.1
Bottomley, S.P.2
Smith, D.P.3
Ciccotosto, G.D.4
Babon, J.5
Hinds, M.G.6
Masters, C.L.7
Cappai, R.8
Barnham, K.J.9
-
23
-
-
43049131763
-
Abeta-globulomers are formed independently of the fibril pathway
-
Gellermann G.P., Byrnes H., Striebinger A., Ullrich K., Mueller R., Hillen H., Barghorn S. Abeta-globulomers are formed independently of the fibril pathway. Neurobiol. Dis. 2008, 30:212-220.
-
(2008)
Neurobiol. Dis.
, vol.30
, pp. 212-220
-
-
Gellermann, G.P.1
Byrnes, H.2
Striebinger, A.3
Ullrich, K.4
Mueller, R.5
Hillen, H.6
Barghorn, S.7
-
24
-
-
34249860495
-
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct
-
Necula M., Kayed R., Milton S., Glabe C.G. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. J. Biol. Chem. 2007, 282:10311-10324.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10311-10324
-
-
Necula, M.1
Kayed, R.2
Milton, S.3
Glabe, C.G.4
-
25
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti F., Dobson C.M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 2006, 75:333-366.
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
26
-
-
33845978790
-
Insight into the structure of amyloid fibrils from the analysis of globular proteins
-
Trovato A., Chiti F., Maritan A., Seno F. Insight into the structure of amyloid fibrils from the analysis of globular proteins. PLoS Comput. Biol. 2006, 2:e170.
-
(2006)
PLoS Comput. Biol.
, vol.2
-
-
Trovato, A.1
Chiti, F.2
Maritan, A.3
Seno, F.4
-
27
-
-
0037168655
-
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR
-
Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., Delaglio F., Tycko R. A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl. Acad. Sci. USA 2002, 99:16742-16747.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
Antzutkin, O.N.4
Leapman, R.D.5
Delaglio, F.6
Tycko, R.7
-
28
-
-
5044235541
-
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
-
Fernandez-Escamilla A.M., Rousseau F., Schymkowitz J., Serrano L. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat. Biotechnol. 2004, 22:1302-1306.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1302-1306
-
-
Fernandez-Escamilla, A.M.1
Rousseau, F.2
Schymkowitz, J.3
Serrano, L.4
-
29
-
-
0031587286
-
Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils
-
Alvarez A., Opazo C., Alarcon R., Garrido J., Inestrosa N.C. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. J. Mol. Biol. 1997, 272:348-361.
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 348-361
-
-
Alvarez, A.1
Opazo, C.2
Alarcon, R.3
Garrido, J.4
Inestrosa, N.C.5
-
30
-
-
64549140676
-
Structural characterization of a soluble amyloid beta-peptide oligomer
-
Yu L., Edalji R., Harlan J.E., Holzman T.F., Lopez A.P., Labkovsky B., Hillen H., Barghorn S., Ebert U., Richardson P.L., Miesbauer L., Solomon L., Bartley D., Walter K., Johnson R.W., Hajduk P.J., Olejniczak E.T. Structural characterization of a soluble amyloid beta-peptide oligomer. Biochemistry 2009, 48:1870-1877.
-
(2009)
Biochemistry
, vol.48
, pp. 1870-1877
-
-
Yu, L.1
Edalji, R.2
Harlan, J.E.3
Holzman, T.F.4
Lopez, A.P.5
Labkovsky, B.6
Hillen, H.7
Barghorn, S.8
Ebert, U.9
Richardson, P.L.10
Miesbauer, L.11
Solomon, L.12
Bartley, D.13
Walter, K.14
Johnson, R.W.15
Hajduk, P.J.16
Olejniczak, E.T.17
-
31
-
-
77954892793
-
Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape
-
Miller Y., Ma B., Nussinov R. Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape. Chem. Rev. 2010, 110:4820-4838.
-
(2010)
Chem. Rev.
, vol.110
, pp. 4820-4838
-
-
Miller, Y.1
Ma, B.2
Nussinov, R.3
-
32
-
-
22444449900
-
On the nucleation of amyloid beta-protein monomer folding
-
Lazo N.D., Grant M.A., Condron M.C., Rigby A.C., Teplow D.B. On the nucleation of amyloid beta-protein monomer folding. Protein Sci. 2005, 14:1581-1596.
-
(2005)
Protein Sci.
, vol.14
, pp. 1581-1596
-
-
Lazo, N.D.1
Grant, M.A.2
Condron, M.C.3
Rigby, A.C.4
Teplow, D.B.5
-
33
-
-
33846565857
-
Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates
-
Cerda-Costa N., Esteras-Chopo A., Aviles F.X., Serrano L., Villegas V. Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates. J. Mol. Biol. 2007, 366:1351-1363.
-
(2007)
J. Mol. Biol.
, vol.366
, pp. 1351-1363
-
-
Cerda-Costa, N.1
Esteras-Chopo, A.2
Aviles, F.X.3
Serrano, L.4
Villegas, V.5
-
34
-
-
77957257176
-
Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering
-
Sandberg A., Luheshi L.M., Sollvander S., Pereira de Barros T., Macao B., Knowles T.P., Biverstal H., Lendel C., Ekholm-Petterson F., Dubnovitsky A., Lannfelt L., Dobson C.M., Hard T. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proc. Natl. Acad. Sci. USA 2010, 107:15595-15600.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15595-15600
-
-
Sandberg, A.1
Luheshi, L.M.2
Sollvander, S.3
Pereira de Barros, T.4
Macao, B.5
Knowles, T.P.6
Biverstal, H.7
Lendel, C.8
Ekholm-Petterson, F.9
Dubnovitsky, A.10
Lannfelt, L.11
Dobson, C.M.12
Hard, T.13
-
35
-
-
67849106670
-
Amyloid-beta protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
-
Bernstein S.L., Dupuis N.F., Lazo N.D., Wyttenbach T., Condron M.M., Bitan G., Teplow D.B., Shea J.E., Ruotolo B.T., Robinson C.V., Bowers M.T. Amyloid-beta protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease. Nat. Chem. 2009, 1:326-331.
-
(2009)
Nat. Chem.
, vol.1
, pp. 326-331
-
-
Bernstein, S.L.1
Dupuis, N.F.2
Lazo, N.D.3
Wyttenbach, T.4
Condron, M.M.5
Bitan, G.6
Teplow, D.B.7
Shea, J.E.8
Ruotolo, B.T.9
Robinson, C.V.10
Bowers, M.T.11
-
36
-
-
79953198908
-
Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices
-
Berger F., Hensel A., Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience 2011, 180:238-247.
-
(2011)
Neuroscience
, vol.180
, pp. 238-247
-
-
Berger, F.1
Hensel, A.2
Nieber, K.3
-
37
-
-
57649148788
-
Structural classification of toxic amyloid oligomers
-
Glabe C.G. Structural classification of toxic amyloid oligomers. J. Biol. Chem. 2008, 283:29639-29643.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 29639-29643
-
-
Glabe, C.G.1
-
38
-
-
41349107779
-
Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro
-
Yoshihara T., Takiguchi S., Kyuno A., Tanaka K., Kuba S., Hashiguchi S., Ito Y., Hashimoto T., Iwatsubo T., Tsuyama S., Nakashima T., Sugimura K. Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro. J. Biochem. 2008, 143:475-486.
-
(2008)
J. Biochem.
, vol.143
, pp. 475-486
-
-
Yoshihara, T.1
Takiguchi, S.2
Kyuno, A.3
Tanaka, K.4
Kuba, S.5
Hashiguchi, S.6
Ito, Y.7
Hashimoto, T.8
Iwatsubo, T.9
Tsuyama, S.10
Nakashima, T.11
Sugimura, K.12
-
39
-
-
80053595082
-
Protein engineering to stabilize soluble amyloid beta-protein aggregates for structural and functional studies
-
Hard T. Protein engineering to stabilize soluble amyloid beta-protein aggregates for structural and functional studies. FEBS J. 2011, 10.1111/j.1742-4658.2011.08295.x.
-
(2011)
FEBS J.
-
-
Hard, T.1
|