Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)

Neurological Sciences

Volumn 32, Issue 4, 2011, Pages 653-659

  Armstrong, Richard A ^a   Cairns, Nigel J ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Frontotemporal lobar degeneration with TDP 43 proteinopathy (FTLD TDP); Neuronal cytoplasmic inclusions (NCI); Spatial pattern; TAR DNA binding protein of 43 kDa (TDP 43)

Indexed keywords

TAR DNA BINDING PROTEIN;

ARTICLE; BRAIN WEIGHT; CELL COUNT; CELL INCLUSION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; DENTATE GYRUS; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FRONTOTEMPORAL DEMENTIA; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INFERIOR TEMPORAL GYRUS; MALE; MIDDLE TEMPORAL GYRUS; PARAHIPPOCAMPAL GYRUS; TDP 43 PROTEINOPATHY;

ADULT; AGED; DATA INTERPRETATION, STATISTICAL; DNA-BINDING PROTEINS; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; MALE; MIDDLE AGED; NERVE DEGENERATION; NEURAL PATHWAYS; TDP-43 PROTEINOPATHIES;

EID: 80054004766     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-011-0639-8     Document Type: Article

References (43)

1. Wang HY, Wang IF, Bose J, Shen CKJ (2004) Structural diversity and functional implications of the eukaryotic TDP gene family. Genomics 83:130-139 (Pubitemid 37518267)
2. Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VMY (2007) Absence of heterogeneous nuclear riboproteins and survival neuron protein (TDP-43) positive inclusions in frontotemporal lobar degeneration. Acta Neuropathol 113:543-548 (Pubitemid 46672600)
3. Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL III, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Steiber A, Xu Y, Forman MS, Trojanowski JQ, Lee VMY, Mackenzie IRA (2007) TDP-43 familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol 171:227-240 (Pubitemid 47342406)
4. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M (2006) Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442:916-919 (Pubitemid 44285946)
5. Cruts M, Gijselink I, van der ZJ, Engelborgs S, Wils H, Pirici D, Radamakers R, Vandenberghe R, Dermaut B, Martin JJ, van Duijn C, Peeters K, Sciot R, Santens P, De pooter T, Mattheijssens M, van den BM, Cuijt I, Vennekens K, De Deyn PP, Kumar-Singh S, Van Broeckhoven C. (2006) Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 442:920-924 (Pubitemid 44285947)
6. Rademakers R, Hutton M (2007) The genetics of frontotemporal lobar degeneration. Curr Neurol Neurosci Rep 7:434-442 (Pubitemid 47422786)
7. Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestrvik A, Smith TN, Tu PH, Watts GDJ, Markesbery WR, Smith CD, Kimonis VE (2006) Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol 65:571-581 (Pubitemid 44288941)
8. Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M (2008) Concomitant TDP-43 pathology is present in Alzheimer's disease and corticobasal degeneration but not in other tauopathies. J Neuropathol Exp Neurol 67:555-564 (Pubitemid 351787082)
9. Higashi S, Iseki E, Yamamoto R, Minegishi M, Hino H, Fujisawa K, Togo T, Katsuse O, Uchikado H, Furiukawa Y, Kosaka K, Arai H (2007) Concurrence of TDP-43, tau and a-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies. Brain Res 1184:284-294 (Pubitemid 350160566)
10. Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VMY, Trojanowski JQ (2008) Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathol 115:123-131 (Pubitemid 50003187)
11. Amandor-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann Neurol 61:435-445 (Pubitemid 46878771)
12. Hasegawa M, Arai T, Akiyama H, Noriaka T, Mori H, Hashimoto T, Yamazaki M, Oyanagi K (2007) TDP-43 is deposited in the Guam parkinsonism-dementia complex brain. Brain 130:1386-1394 (Pubitemid 47355958)
13. Cairns NJ, Perry RH, Jaros E, Burn D, McKeith IG, Lowe JS, Holton J, Rossor MN, Skullerud K, Duyckaerts C, Cruz-Sanchez FF, Lantos PL (2003) Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions. Neurosci Lett 341:177-180 (Pubitemid 36403757)
14. Mackenzie IRA, Baker M, Pickering-Brown S, Hsinng GYR, Lindholm C, Dwosh E, Cannon A, Rademakers R, Hutton M, Feldman HH (2006) The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene. Brain 129:3081-3090 (Pubitemid 44684527)
15. Cairns NJ, Bigio EH, Mackenzie IRA, Neumann M, Lee VMY, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DMA (2007) Neuropathologic diagnostic and nosological criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114:5-22 (Pubitemid 47029055)
16. Goedert M, Spillantini MG, Serpell LC, Berriman J, Smith MJ, Jakes R, Crowther RA (2001) From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. Phil Trans Roy Soc (Lond) B. Biol Sci 356:213-227 (Pubitemid 32241470)
17. Cairns NJ, Lee VM-Y, Trojanowski JQ (2004) The cytoskeleton in neurodegenerative disease. J Pathol 204:438-449
18. Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VMY, Trojanowski JQ (2004) a-Internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol 164:2153-2161 (Pubitemid 38669362)
19. Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mckenzie IRA, Perry RH, Skullerud K, Yokoo H, Cairns NJ (2011) The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease. Acta Neuropathol 121:219-228
20. Neumann M, Roeher S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IRA (2009) Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease (NIFID). Acta Neuropathol 118:605-616
21. Yokota O, Tsuchiya K, Terada S, Ishizu H, Uchikado H, Ikeda M, Oyanagi K, Nakaro I, Murayama S, Kuroda S, Akiyama H (2008) Basophilic inclusion body disease and neuronal intermediate filament inclusion disease: a comparative clinicopathological study. Acta Neuropathol 115:561-575
22. Armstrong RA, Cairns NJ, Lantos PL (1998) Clustering of Pick bodies in Pick's disease. Neurosci Lett 242:81-84 (Pubitemid 28082998)
23. Armstrong RA, Cairns NJ, Lantos PL (1999) Clustering of cerebral cortical lesions in patients with corticobasal degeneration. Neurosci Lett 268:5-8 (Pubitemid 29292531)
24. Armstrong RA, Cairns NJ, Lantos PL (1997) Dementia with Lewy bodies: clustering of Lewy bodies in human patients. Neurosci Lett 224:41-44 (Pubitemid 27112865)
25. Armstrong RA, Lantos PL, Cairns NJ (2004) Spatial patterns of a-synuclein positive glial cytoplasmic inclusions in multiple system atrophy. Move Disord 19:109-112 (Pubitemid 38559631)
26. Armstrong RA, Cairns NJ (2006) Topography of a-internexinpositive neuronal aggregates in 10 patients with neuronal intermediate filament inclusion disease. Eur J Neurol 13:528-532 (Pubitemid 43823370)
27. Armstrong RA, Ellis W, Hamilton RL, Mackenzie IRA, Hedreen J, Gearing M, Montine T, Vonsattel J-P, Head E, Lieberman AP, Cairns NJ (2010) Neuropathological heterogeneity infrontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm 117:227-239
28. Josephs KA, Knopman DS, Whitwell JL, Boeve BF, Parisi JE, Petersen RC, Dickson DW (2005) Survival in the two variants of tau negative FTLD: FTLD-TDP versus FTLD-MND. Neurology 65:645-647 (Pubitemid 41170737)
29. Kersaitis C, Holliday GM, Xuereb JH, Pamphlett R, Bak TH, Hodges JR, Kril JJ (2006) Ubiquitin-positive inclusions and progression of pathology in FTD and MND identifies a groupwith mainly early pathology. Neuropathol Appl Neurobiol 32:83-91
30. Kovari E, Gold G, Giannakopoulos P, Bouras C (2004) Cortical ubiquitin positive inclusions in frontotemporal dementia without motor neuron disease: a quantitative immunocytochemical study. Acta Neuropathol 108:207-212 (Pubitemid 39199512)
31. Yaguchi M, Fujita Y, Amari M, Takatama M, Al-Sarraj S, Leigh PN, Okamoto K (2004) Morphological differences of intraneural ubiquitin positive inclusions in the dentate gyrus and parahippocampal gyrus of motor neuron disease with dementia. Neuropathol 24:296-301 (Pubitemid 39664751)
32. Armstrong RA (1993) The usefulness of spatial pattern analysis in understanding the pathogenesis of neurodegenerative disorders, with particular reference to plaque formation in Alzheimer's disease. Neurodegeneration 2:73-80
33. Armstrong RA (1997) Analysis of spatial patterns in histological sections of brain tissue. J Neurosci Method 73:141-147 (Pubitemid 27244810)
34. Armstrong RA (2006) Methods of studying the planar distribution of objects in histological sections of brain tissue. J Microsc (Oxf) 221:153-158
35. Braak H, Braak E, Bohl J (1993) Staging of Alzheimer-related cortical destruction. Eur Neurol 33:403-408 (Pubitemid 23358066)
36. Armstrong RA (1993) Is the clustering of neurofibrillary tangles in Alzheimer's patients related to the cells of origin of specific cortico-cortical projections? Neurosci Lett 160:57-60 (Pubitemid 23287601)
37. De Lacoste M, White CL III (1993) The role of cortical connectivity in Alzheimer's disease pathogenesis: a review and model system. Neurobiol Aging 14:1-16 (Pubitemid 23043049)
38. Hiorns RW, Neal JW, Pearson RCA, Powell TPS (1991) Clustering of ipsilateral cortico-cortical projection neurons to area 7 in the Rhesus monkey. Proc Roy Soc Lond 246:1-9
39. Delatour B, Blanchard V, Pradier L, Duyckaerts C (2004) Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model. Neurobiol Dis 16:41-47 (Pubitemid 38569794)
40. Yang Y, Schmitt HP (2001) Frontotemporal dementia: evidence for impairment of ascending sertinergic but not noradrenergic innervation: immunocytochemical and quantitative study using a graph method. Acta Neuropathol 101:256-270 (Pubitemid 32219760)
41. Armstrong RA, Cairns NJ, Lantos PL (2002) Are pathological lesions in neurodegenerative disorders the cause or the effect of the degeneration? Neuropathol 22:114-127
42. Neumann M, Kwong LK, Truax AC, Vanmassenhove B, Kretzschmar JQ, Lee VMY (2007) TDP-43 positive white matter pathology in frontotemporal lobar degeneration with ubiquitinpositive inclusions. J Neuropath Exp Neurol 66:177-183 (Pubitemid 46673273)
43. Armstrong RA, Cairns NJ, Lantos PL (2001) What does the study of spatial patterns tell us about the pathogenesis of neurodegenerative disorders? Neuropathol 21:1-12 (Pubitemid 32280381)