What does the study of the spatial patterns of pathological lesions tell us about the pathogenesis of neurodegenerative disorders?

Neuropathology

Volumn 21, Issue 1, 2001, Pages 1-12

  Armstrong, Richard A ^a   Cairns, Nigel J ^b   Lantos, Peter L ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Blood vessels; Clustering; Cortico cortical projections; Neurodegenerative disorders; Pathological lesions; Poisson distribution; Spatial patterns

Indexed keywords

ALZHEIMER DISEASE; BLOOD VESSEL; BRAIN INJURY; CELL STRUCTURE; CORTICOBASAL DEGENERATION; CREUTZFELDT JAKOB DISEASE; DEGENERATIVE DISEASE; DOWN SYNDROME; LEWY BODY; NEUROANATOMY; NEUROPATHOLOGY; PATHOGENESIS; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; REVIEW; STATISTICAL ANALYSIS;

BRAIN; HUMANS; NEURAL PATHWAYS; NEURODEGENERATIVE DISEASES; POISSON DISTRIBUTION;

EID: 0035065090     PISSN: 09196544     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1789.2001.00373.x     Document Type: Review

References (73)

1. β-amyloid plaques: Stages in life history or independent origin?
2. Alzheimer's disease: Initial report of the purification and characterisation of a novel cerebrovascular amyloid protein
3. Presence of apolipoprotein ε on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer β-amyloid deposition
4. Alzheimer and Down's patients: Cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques
5. 40 compared with sporadic Alzheimer's disease
6. Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain stem in Lewy body disease
7. Microtubule-associated protein-5 is a component of Lewy bodies and Lewy body neurites in the brain stem and forebrain regions affected in Parkinson's disease
8. Cortical and brain stem type Lewy bodies are immunoreactive for the cyclin dependent kinase-5
9. Ubiquitin in neurodegenerative diseases
10. Purification and characterisation of Lewy bodies from the brains of patients with diffuse Lewy body disease
11. Alpha-synuclein accumulates in Lewy bodies in Parkinson's disease and dementia with Lewy bodies but not in Alzheimer's disease beta amyloid plaque cores
12. Alz-50, Ubiquitin and tau immunoreactivity of neurofibrillary tangles, Pick bodies and Lewy bodies
13. Ultrastructural instability of paired helical filaments from corticobasal degeneration as examined by scanning transmission electron microscopy
14. Paired helical filaments in corticobasal degeneration: The fine fibrillary structure with NanoVan
15. Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease
16. The new neuropathology of degenerative frontotemporal dementias
17. White matter lesions on MRI in dementia with Lewy bodies, Alzheimer's disease, vascular dementia and normal aging
18. The usefulness of spatial pattern analysis in understanding the pathogenesis of neurodegenerative disorders, with special reference to plaque formation in Alzheimer's disease
19. Analysis of spatial patterns in histological sections of brain tissue
20. Analysis of spatial patterns in histological sections of brain tissue using a method based on regression
21. The spatial patterns of β/A4 deposit subtypes and blood vessels in Alzheimer's disease cases with pronounced congophilic angiopathy
22. Is the clustering of β-amyloid (Aß) deposits in the frontal cortex of Alzheimer patients determined by blood vessels?
23. Lewy body and Alzheimer pathology in temporal lobe in dementia with Lewy bodies
24. The spatial pattern of the vacuolation in patients with sporadic Creutzfeldt-Jakob disease
25. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease
26. The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
27. Cortical somatostatin, neuropeptide Y and NADPH diaphorase neurons: Normal anatomy and alterations in Alzheimer's disease
28. Clustering of cerebral cortical lesions in patients with corticobasal degeneration
29. Alzheimer's disease: Are cellular neurofibrillary tangles linked to β/A4 formation at the projection sites?
30. The spatial patterns of β/A4 deposit subtypes in Alzheimer's disease
31. Morphological study of amyloid fibrils and preamyloid deposits in the brain with Alzheimer's disease
32. The blood-brain barrier in Alzheimer's disease
33. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease
34. A quantitative study of the coincidence of blood vessels and A4 protein deposits in Alzheimer's disease
35. Neuritic plaques and vessels of visual cortex in aging and Alzheimer's dementia
36. Clustering of ipsilateral cortico-cortical projection neurons to area 7 in the rhesus monkey
37. Laminar distribution of Pick bodies, Pick cells and Alzheimer disease pathology in Pick's disease
38. Ubiquitin positive lesions in corticobasal degeneration
39. Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases
40. Cerebral type of Lewy Body Disease
41. Patterns of regional cerebral blood flow in corticobasal degeneration using HMPAO SPECT. Comparison with Parkinson's disease and normal controls
42. Basal ganglia lesions in corticobasal degeneration differ from those in Pick's disease and progressive supranuclear palsy: A topographic neuropathological study of 6 autopsy cases
43. Cortical ballooned neurons in progressive supranuclear palsy
44. Wernicke's encephalopathy with ballooned neurons in the mamillary bodies: An immunohistochemical study
45. Synaptophysin expression in the anterior horn of Werdnig-Hoffman disease
46. Alzheimer's disease: The amyloid cascade hypothesis
47. The spatial patterns of plaques and tangles in Alzheimer's disease do not support the 'Cascade hypotheses'
48. Dissociation of Alzheimer type pathology in a disconnected piece of cortex
49. Is the clustering of neurofibrillary tangles in Alzheimer's patients related to the cells of origin of specific cortico-cortical projections?
50. Dementia with Lewy bodies: Clustering of Lewy bodies in human patients
51. β/A4 deposits and their relationship to senile plaques in Alzheimer's disease
52. Some modular features of temporal cortex in humans as revealed by pathological changes in Alzheimer's disease
53. Alzheimer's disease: Size class frequency distributions of senile plaques: Do they indicate when a brain tissue was affected?
54. MRI volumetric study of dementia with Lewy bodies: Comparison with Alzheimer's disease and vascular dementia
55. The medial temporal lobe in dementia with Lewy bodies: A comparative study with Alzheimer's disease
56. Regional cerebral blood flow difference between dementia with Lewy bodies and Alzheimer's disease
57. Parvalbumin-immunoreactive neurons in the cortex in Pick's disease
58. Basic pathology of corticobasal degeneration
59. Influence of neuronal location on antigenic properties of neurofibrillary tangles
60. Lewy bodies in Alzheimer's disease in which the primary lesion is a mutation in the amyloid precursor protein
61. Familial Alzheimer's disease and cortical Lewy bodies: Is there a genetic susceptibility factor
62. Axonal and transneural transport in the transmission of neurological disease: Potential role in system degenerations including Alzheimer's disease
63. Does the neurodegeneration of Alzheimer's disease spread between visual cortical areas B17 and B18 via the feedforward or feedback short cortico-cortical projections?
64. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer's disease
65. The role of amyloid β-protein in Alzheimer's disease
66. β-amyloid precursor protein (βAPP) as a marker for axonal injury after head injury
67. Immunoreactive changes resulting from dopaminergic denervation of the dentate gyrus of the rat hippocampal formation
68. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
69. Alpha-synuclein and Parkinson's disease: Selected neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo
70. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
71. Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury
72. Degenerative terminals of the perforant pathway are human alpha-synuclein immunoreactive in the hippocampus of patients with diffuse Lewy body disease