Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Na, Bing ^a,b   Huang, Zhiming ^a   Wang, Qian ^a   Qi, Zhongxia ^b   Tian, Yongjun ^c   Lu, Cheng Chan ^d   Yu, Jingwei ^b   Hanes, Martha A ^e   Kakar, Sanjay ^a,b   Huang, Eric J ^a,b   Ou, J H James ^c   Liu, Limin ^b   Yen, T S Benedict ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEPATITIS B; HEPATITIS B VIRUS; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER INJURY; LIVER NECROSIS; MOUSE; NONHUMAN; ONCOGENE; TRANSGENE; TRANSGENICS; TUMOR SUPPRESSOR GENE; VIRUS CARCINOGENESIS; VIRUS DNA CELL DNA INTERACTION; VIRUS EXPRESSION; VIRUS GENOME; WILD TYPE; ANIMAL; CHRONIC DISEASE; GENE EXPRESSION REGULATION; GENETICS; INJURY; LIVER; LIVER TUMOR; MALE; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; UNFOLDED PROTEIN RESPONSE; VIROLOGY; VIRUS REPLICATION;

HEPATITIS B VIRUS; MUS; MUS MUSCULUS;

BETA CATENIN; CYCLIN D1;

ANIMALS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CHRONIC DISEASE; CYCLIN D1; HEPATITIS B VIRUS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; MUTATION; UNFOLDED PROTEIN RESPONSE; VIRUS REPLICATION;

EID: 80053994563     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026240     Document Type: Article

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