ISG15 modulates development of the erythroid lineage

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Maragno, Ana Leticia ^a,b,c   Pironin, Martine ^a,b,c   Alcalde, Hélène ^a,b,c   Cong, Xiuli ^f   Knobeloch, Klaus Peter ^d   Tangy, Frederic ^e   Zhang, Dong Er ^f   Ghysdael, Jacques ^a,b,c   Quang, Christine Tran ^a,b,c  

^a CNRS   (France)

^b INSERM   (France)

^c INSTITUT CURIE   (France)

^d UNIVERSITY OF FREIBURG   (Germany)

^e INSTITUT PASTEUR   (France)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBIN; GLYCOPHORIN A; ISG15 PROTEIN; STAT PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; CYTOKINE; ERYTHROPOIETIN; G1P2 PROTEIN, MOUSE; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOLIPASE C GAMMA; STAT5 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROCYTE; ERYTHROID CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SYNTHESIS; PROTEIN TARGETING; SPLEEN; ANIMAL; CYTOLOGY; ENZYMOLOGY; METABOLISM; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALIA; MUS;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; ERYTHROBLASTS; ERYTHROID CELLS; ERYTHROPOIETIN; GLOBINS; INTERFERONS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHOLIPASE C GAMMA; SIGNAL TRANSDUCTION; SPLEEN; STAT5 TRANSCRIPTION FACTOR; UBIQUITINATION; UBIQUITINS;

EID: 80053933498     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026068     Document Type: Article

References (47)

1. Socolovsky M, (2007) Molecular insights into stress erythropoiesis. Curr Opin Hematol 14: 215-224.
2. Wu H, Liu X, Jaenisch R, Lodish HF, (1995) Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83: 59-67.
3. von Lindern M, Schmidt U, Beug H, (2004) Control of erythropoiesis by erythropoietin and stem cell factor: a novel role for Bruton's tyrosine kinase. Cell Cycle 3: 876-879.
4. Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, et al. (2006) Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A 103: 1000-1005.
5. Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, et al. (2008) Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 112: 3878-3888.
6. Zhu BM, McLaughlin SK, Na R, Liu J, Cui Y, et al. (2008) Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood 112: 2071-2080.
7. Halupa A, Bailey ML, Huang K, Iscove NN, Levy DE, et al. (2005) A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood 105: 552-561.
8. Reich N, Evans B, Levy D, Fahey D, Knight E Jr, et al. (1987) Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A 84: 6394-6398.
9. Ritchie KJ, Zhang DE, (2004) ISG15: the immunological kin of ubiquitin. Semin Cell Dev Biol 15: 237-246.
10. Zhang X, Zhang D, (2010) ISG15 and the protein ISGylation system. J Interferon Cytokine Res Accepted for publication.
11. Durfee LA, Lyon N, Seo K, Huibregtse JM, (2010) The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15. Mol Cell 38: 722-732.
12. Okumura A, Pitha PM, Harty RN, (2008) ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity. Proc Natl Acad Sci U S A 105: 3974-3979.
13. Shi HX, Yang K, Liu X, Liu XY, Wei B, et al. (2010) Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification. Mol Cell Biol 30: 2424-2436.
14. Osiak A, Utermohlen O, Niendorf S, Horak I, Knobeloch KP, (2005) ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol 25: 6338-6345.
15. Zhang J, Socolovsky M, Gross AW, Lodish HF, (2003) Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood 102: 3938-3946.
16. Gregoli PA, Bondurant MC, (1997) The roles of Bcl-X(L) and apopain in the control of erythropoiesis by erythropoietin. Blood 90: 630-640.
17. Dolznig H, Grebien F, Deiner EM, Stangl K, Kolbus A, et al. (2006) Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene 25: 2890-2900.
18. Fang J, Menon M, Zhang D, Torbett B, Oxburgh L, et al. (2008) Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2. Blood 112: 886-890.
19. Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, et al. (1994) Functional role of type I and type II interferons in antiviral defense. Science 264: 1918-1921.
20. von Lindern M, Deiner EM, Dolznig H, Parren-Van Amelsvoort M, Hayman MJ, et al. (2001) Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene 20: 3651-3664.
21. Dolznig H, Boulme F, Stangl K, Deiner EM, Mikulits W, et al. (2001) Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays. Faseb J 15: 1442-1444.
22. Dolznig H, Habermann B, Stangl K, Deiner EM, Moriggl R, et al. (2002) Apoptosis protection by the Epo target Bcl-X(L) allows factor-independent differentiation of primary erythroblasts. Curr Biol 12: 1076-1085.
23. Lesault I, Quang CT, Frampton J, Ghysdael J, (2002) Direct regulation of BCL-2 by FLI-1 is involved in the survival of FLI-1-transformed erythroblasts. Embo J 21: 694-703.
24. Desai SD, Haas AL, Wood LM, Tsai YC, Pestka S, et al. (2006) Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res 66: 921-928.
25. Malakhova OA, Zhang DE, (2008) ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response. J Biol Chem 283: 8783-8787.
26. Tian C, Gregoli P, Bondurant M, (2003) The function of the bcl-x promoter in erythroid progenitor cells. Blood 101: 2235-2242.
27. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, et al. (2001) Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 98: 3261-3273.
28. Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, et al. (2007) Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A 104: 6794-6799.
29. Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL, (2003) The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Blood 102: 712-717.
30. Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, et al. (2007) NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104: 19500-19505.
31. Zermati Y, Garrido C, Amsellem S, Fishelson S, Bouscary D, et al. (2001) Caspase activation is required for terminal erythroid differentiation. J Exp Med 193: 247-254.
32. Kolbus A, Pilat S, Husak Z, Deiner EM, Stengl G, et al. (2002) Raf-1 antagonizes erythroid differentiation by restraining caspase activation. J Exp Med 196: 1347-1353.
33. Owhashi M, Taoka Y, Ishii K, Nakazawa S, Uemura H, et al. (2003) Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor. Biochem Biophys Res Commun 309: 533-539.
34. Okumura F, Zou W, Zhang DE, (2007) ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev 21: 255-260.
35. Pincetic A, Kuang Z, Seo EJ, Leis J, (2010) The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process. J Virol 84: 4725-4736.
36. Liao HJ, Kume T, McKay C, Xu MJ, Ihle JN, et al. (2002) Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem 277: 9335-9341.
37. Guihard S, Clay D, Cocault L, Saulnier N, Opolon P, et al. (2010) The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 115: 3686-3694.
38. Zhao C, Beaudenon SL, Kelley ML, Waddell MB, Yuan W, et al. (2004) The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proc Natl Acad Sci U S A 101: 7578-7582.
39. Kim KI, Giannakopoulos NV, Virgin HW, Zhang DE, (2004) Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol 24: 9592-9600.
40. Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H, (2005) Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. J Biochem 138: 711-719.
41. Lee TL, Shyu YC, Hsu TY, Shen CK, (2008) Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination. Biochem Biophys Res Commun 375: 326-330.
42. Quadrini KJ, Bieker JJ, (2006) EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome. FEBS Lett 580: 2285-2293.
43. Li B, Jia N, Kapur R, Chun KT, (2006) Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis. Blood 107: 4291-4299.
44. Liu J, Guo X, Mohandas N, Chasis JA, An X, (2010) Membrane remodeling during reticulocyte maturation. Blood 115: 2021-2027.
45. Morita S, Kojima T, Kitamura T, (2000) Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 7: 1063-1066.
46. Lebigot I, Gardellin P, Lefebvre L, Beug H, Ghysdael J, et al. (2003) Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling. Blood 102: 4555-4562.
47. Versteeg GA, Hale BG, van Boheemen S, Wolff T, Lenschow DJ, et al. (2010) Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein. J Virol 84: 5423-5430.