The function of the bcl-x promoter in erythroid progenitor cells

Blood

Volumn 101, Issue 6, 2003, Pages 2235-2242

  Tian, Cuixia ^a   Gregoli, Paul ^a   Bondurant, Maurice ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MESSENGER RNA; NUCLEAR PROTEIN; OLIGONUCLEOTIDE; PROTEIN BCL X; VIRUS VECTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BASE PAIRING; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; ENHANCER REGION; ENZYME ASSAY; ERYTHROBLAST; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; GENE FUNCTION; GENE FUSION; GENE MAPPING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM; REPORTER GENE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIMIAN VIRUS 40; START CODON; TRANSCRIPTION INITIATION SITE;

EID: 0037443393     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-04-1217     Document Type: Article

References (26)

1. Motoyama N, Wang F, Roth K, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science. 1995;267:1506-1510.
2. Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression. Blood. 1999;94:87-96.
3. Motoyama N, Kimura T, Takahashi T, Watanabe T, Nakano T. bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. J Exp Med. 1999;189:1691-1698.
4. Wagner K-U, Estefania C, Rucker EB, et al. Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly. Development. 2000;127:4949-4958.
5. Okada S, Zhang H, Hatano M, Tokuhisa T. A physiologic role of Bcl-xL induced in activated macrophages. J Immunol. 1998;160:2590-2596.
6. Hettmann T, DiDonato J, Karin M, Leiden JM. An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med. 1999;189:145-158.
7. Wells AD, Li XC, Li Y, et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med. 1999;5:1303-1307.
8. Schwarze M, Hawley RG. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin-6 up-regulation of bcl-xL. Cancer Res. 1995;55:2262-2265.
9. Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K, Kishimoto T. Signals through gp130 upregulate bcl-x gene expression via stat1-binding cis-element in cardiac myocytes. J Clin Invest. 1997;99:2898-2905.
10. Silva M, Grillot D, Benito A, Richard C, Nunez G, Fernandez-Luna JL. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-xL and Bcl-2. Blood. 1996;88:1576-1582.
11. Sevilla L, Aperlo C, Dulic V, et al. The Ets2 transcription factor inhibits apoptosis induced by colony-stimulating factor 1 deprivation of macrophages through a Bcl-xL-dependent mechanism. Mol Cell Biol. 1999;19:2624-2634.
12. Silva M, Benito A, Sanz C, et al. Erythropoietin can induce the expression of Bcl-xL through STAT5 in erythropoietin-dependent progenitor cell lines. J Biol Chem. 1999;274:22165-22169.
13. Socolovsky M, Fallon AJ, Wang S, Brugnara C, Lodish HF. Fetal anemia and apoptosis of erythroid cell progenitors in stat5a-/-5b-/- mice: a direct role for stat5 in bcl-xL induction. Cell. 1999; 98:181-191.
14. Margue CM, Bernasxoni M, Barr FG, Schafer BW. Transcriptional modulation of the antiapoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene. 2000;19:2921-2929.
15. Glasgow JN, Wood T, Perez-Polo JR. Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter. J Neurochem. 2000;75:1377-1389.
16. Grillot DAM, Gonzalez-Garcia M, Ekhterae D, et al. Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. J Immunol. 1997;158:4750-4757.
17. MacCarthy-Morrogh L, Wood L, Brimmell M, Johnson PWM, Packham G. Identification of a novel human BCL-X promoter and exon. Oncogene. 2000;19:5534-5538.
18. Pecci A, Viegas LR, Baranao JL, Beato M. Promoter choice influences alternative splicing and determines the balance of isoforms expressed from the mouse bcl-x gene. J Biol Chem. 2001; 278:21062-21069.
19. Sugars KL, Budhram-Mahadeo V, Packham G, Latchman DS. A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. Nucleic Acids Research. 2001;29:4530-4540.
20. Gregoli PA, Bondurant MC. The roles of Bcl-xL and apopain in the control of erythropoiesis by erythropoietin. Blood. 1997;90:630-640.
21. Koury MJ, Sawyer ST, Bondurant MC. Splenic erythroblasts in anemia-inducing Friend disease: a source of cells for studies of erythropoietin-mediated differentiation. J Cell Physiol. 1984;121:526-532.
22. Sawada K, Krantz SB, Dai CH, et al. Purification of human blood burst-forming units and demonstration of specific binding of erythropoietin. J Clin Invest. 1987;80:357-366.
23. Spivak JL, Pham T, Isaacs M, Hankins WD. Erythropoietin is both a mitogen and a survival factor. Blood. 1991;77:1228-1233.
24. Dignam JD, Libovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res. 1983;11:1475-1489.
25. Singh H, Sen R, Baltimore D, Sharp PA. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature. 1986;319:154-158.
26. Chodosh L. Mobility shift DNA-binding assay using gel electrophoresis. In: Ausbubel FM, Brent R, Kingston RE, et al, eds. Short Protocols in Molecular Biology. 3rd ed. John Wiley & Sons, Hoboken, NJ; 1995:chap 12:7-9.