The antidepressant desipramine is an arrestin-biased ligand at the α2A-adrenergic receptor driving receptor down-regulation in vitro and in vivo

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 36063-36075

  Cottingham, Christopher ^a   Chen, Yunjia ^a   Jiao, Kai ^b   Wang, Qin ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOREPINEPHRINE;

ADRENERGIC RECEPTORS; ANTIDEPRESSANT DRUG; ARRESTINS; DIRECT INTERACTIONS; DOWN-REGULATION; HETEROTRIMERIC G PROTEINS; KEY REGULATORS; RECEPTOR EXPRESSION;

PHYSIOLOGICAL MODELS;

ALPHA 2A ADRENERGIC RECEPTOR; DESIPRAMINE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; RETINA S ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SELECTIVITY; EMBRYO; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALIA;

EID: 80053927094     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.261578     Document Type: Article

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