Genetic dissection of α2-adrenoceptor functions in adrenergic versus nonadrenergic cells

Molecular Pharmacology

Volumn 75, Issue 5, 2009, Pages 1160-1170

  Gilsbach, Ralf ^a   Röser, Christoph ^b   Beetz, Nadine ^a   Brede, Marc ^b   Hadamek, Kerstin ^b   Haubold, Miriam ^a   Leemhuis, Jost ^a   Philipp, Melanie ^c   Schneider, Johanna ^a   Urbanski, Michal ^a   Szabo, Bela ^a   Weinshenker, David ^d   Hein, Lutz ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; BRIMONIDINE; DOPAMINE BETA MONOOXYGENASE; MEDETOMIDINE; NORADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANESTHETIC AGENT; HYPNOTIC SEDATIVE AGENT;

ADRENERGIC NERVE CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CELL FUNCTION; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HYPNOSIS; HYPOTHERMIA; LOCOMOTION; MALE; MOUSE; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; NORADRENALIN RELEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEDATION; SYMPATHETIC NERVE; ANIMAL; BODY TEMPERATURE; C57BL MOUSE; COMPARATIVE STUDY; GENETICS; MOTOR ACTIVITY; PHYSIOLOGY; SECRETION; TRANSGENE; TRANSGENIC MOUSE;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANESTHETICS; ANIMALS; BODY TEMPERATURE; HYPNOTICS AND SEDATIVES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-2; TRANSGENES;

EID: 66049126873     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.054544     Document Type: Article

References (37)

1. Blednov YA, Stoffel M, Alva H, and Harris RA (2003) A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A 100:277-282. (Pubitemid 36078065)
2. Bourdélat-Parks BN, Anderson GM, Donaldson ZR, Weiss JM, Bonsall RW, Emery MS, Liles LC, and Weinshenker D (2005) Effects of dopamine β-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in mice. Psychopharmacology (Berl) 183:72-80. (Pubitemid 41484184)
3. 2-adrenoceptor subtypes. Mol Endocrinol 17:1640-1646.
4. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR Jr, and Trendelenburg U (1994) International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46:121-136. (Pubitemid 24185147)
5. 2-adrenergic receptors. Mol Pharmacol 51:711-720.
6. 2-adrenoceptor knockout mice. Eur J Pharmacol 497:301-309.
7. 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res 75:728-737.
8. Gilsbach R and Hein L (2008) Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol 184:261-288.
9. 2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402:181-184.
10. Hein L, Ishii K, Coughlin SR, and Kobilka BK (1994) Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem 269:27719-27726. (Pubitemid 24982978)
11. Hoyle GW, Mercer EH, Palmiter RD, and Brinster RL (1994) Cell-specific expression from the human dopamine β-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements. J Neurosci 14:2455-2463. (Pubitemid 24140877)
12. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
13. Jones BE (2005) From waking to sleeping: neuronal and chemical substrates. Trends Pharmacol Sci 26:578-586. (Pubitemid 41505226)
14. 2- adrenergic agonists. Anesthesiology 93:1345-1349.
15. 2A-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci U S A 94:9950-9955.
16. 2-adrenergic receptor subtypes b and c. Science 273:803-805.
17. Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, and Koch WJ (2007) Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med 13:315-323. (Pubitemid 46376685)
18. 2A-adrenergic receptor subtype. Science 273:801-803.
19. Maze M, Scarfini C, and Cavaliere F (2001) New agents for sedation in the intensive care unit. Crit Care Clin 17:881-897. (Pubitemid 33101686)
20. Mercer EH, Hoyle GW, Kapur RP, Brinster RL, and Palmiter RD (1991) The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron 7:703-716.
21. 2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. J Clin Invest 98:1076-1080.
22. Paxinos G and Franklin KBJ (2001) The Mouse Brain in Stereotaxic Coordinates. Academic Press, NY.
23. Pertovaara A (2006) Noradrenergic pain modulation. Prog Neurobiol 80:53-83.
24. 2-adrenoceptors control vascular development at the interface between mother and embryo. Nat Genet 31:311-315.
25. Sanders RD and Maze M (2007) Adrenergic and cholinergic compounds. Handb Exp Pharmacol 177:251-264.
26. 2C- adrenergic receptors and the risk of congestive heart failure. N Engl J Med 347:1135-1142.
27. 2-adrenoreceptors. J Neural Transm 54:153-163.
28. Starke K, Endo T, and Taube HD (1975) Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity. Nature 254:440-441.
29. Sudhoff TC and Starke K (2008) Neurotransmitter Release. Springer, Heidelberg.
30. 2A-adrenoreceptors. Neuroscience 126:795-803.
31. Thomas SA, Marck BT, Palmiter RD, and Matsumoto AM (1998) Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine β-hydroxylase. J Neurochem 70:2468-2476. (Pubitemid 28252372)
32. Thomas SA, Matsumoto AM, and Palmiter RD (1995) Noradrenaline is essential for mouse fetal development. Nature 374:643-646.
33. 2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch Pharmacol 368:504-512.
34. 2-Adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 129:397-410.
35. Weinshenker D, Ferrucci M, Busceti CL, Biagioni F, Lazzeri G, Liles LC, Lenzi P, Pasquali L, Murri L, Paparelli A, et al. (2008) Genetic or pharmacological blockade of noradrenaline synthesis enhances the neurochemical, behavioral, and neurotoxic effects of methamphetamine. J Neurochem 105:471-483.
36. Weinshenker D and Szot P (2002) The role of catecholamines in seizure susceptibility: new results using genetically engineered mice. Pharmacol Ther 94:213-233. (Pubitemid 34759986)
37. Westfall TC and Westfall DP (2006) Adrenergic agonists and antagonists, in Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL, Lazo JS and Parker KL eds) pp 237-295, McGraw-Hill, New York.