메뉴 건너뛰기




Volumn 16, Issue 5, 2011, Pages 193-200

Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients

Author keywords

Diabetes mellitus; Insulin resistance; Leptin; Metformin; Oxidative stress; Oxidized LDL; Type 2

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; LEPTIN; METFORMIN; OXIDIZED LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

EID: 80053922435     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/1351000211Y.0000000008     Document Type: Article
Times cited : (14)

References (61)
  • 1
    • 0025987977 scopus 로고
    • Oxidative stress: From basic research to clinical application
    • Sies H. Oxidative stress: from basic research to clinical application. Am J Med 1991;91:31S-8S.
    • (1991) Am J Med , vol.91
    • Sies, H.1
  • 4
    • 0023192020 scopus 로고
    • Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis
    • Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA 1987;84:2995-8.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2995-2998
    • Quinn, M.T.1    Parthasarathy, S.2    Fong, L.G.3    Steinberg, D.4
  • 5
    • 44249104442 scopus 로고    scopus 로고
    • Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
    • Holvoet P, Lee DH, Steffes M, Gross M, Jacobs Jr DR. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. Jama 2008;299: 2287-93.
    • (2008) Jama , vol.299 , pp. 2287-2293
    • Holvoet, P.1    Lee, D.H.2    Steffes, M.3    Gross, M.4    Jacobs, D.R.5
  • 6
    • 58149260523 scopus 로고    scopus 로고
    • Association of oxidized low-density lipoprotein and transforming growth factor-beta in type 2 diabetic patients: A cross-sectional study
    • Epub 2008 Dec 9
    • Nakhjavani M, Esteghamati A, Asgarani F, Khalilzadeh O, Nikzamir A, Safari R. Association of oxidized low-density lipoprotein and transforming growth factor-beta in type 2 diabetic patients: a cross-sectional study. Transl Res 2009;153:86-90. Epub 2008 Dec 9.
    • (2009) Transl Res , vol.153 , pp. 86-90
    • Nakhjavani, M.1    Esteghamati, A.2    Asgarani, F.3    Khalilzadeh, O.4    Nikzamir, A.5    Safari, R.6
  • 8
    • 34249697436 scopus 로고    scopus 로고
    • Role of leptin in immunity
    • Lam QL, Lu L. Role of leptin in immunity. Cell Mol Immunol 2007;4:1-13.
    • (2007) Cell Mol Immunol , vol.4 , pp. 1-13
    • Lam, Q.L.1    Lu, L.2
  • 9
    • 0042696057 scopus 로고    scopus 로고
    • Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: The possible novel mechanism for proatherogenic effect of chronic hyperleptinemia
    • Beltowski J, Wojcicka G, Jamroz A. Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia. Atherosclerosis 2003;170:21-9.
    • (2003) Atherosclerosis , vol.170 , pp. 21-29
    • Beltowski, J.1    Wojcicka, G.2    Jamroz, A.3
  • 10
    • 80053896413 scopus 로고
    • The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis
    • Kaur S, Zilmer K, Leping V, Zilmer M. The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis. J Eur Acad Dermatol Venereol 2011;1111:1468-3083.
    • (1111) J Eur Acad Dermatol Venereol , vol.2011 , pp. 1468-3083
    • Kaur, S.1    Zilmer, K.2    Leping, V.3    Zilmer, M.4
  • 11
    • 53249125274 scopus 로고    scopus 로고
    • Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes
    • Epub 2008 Oct 9
    • Konstantinidis D, Paletas K, Koliakos G, Kaloyianni M. Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes. J Vasc Res 2009;46:199-208. Epub 2008 Oct 9.
    • (2009) J Vasc Res , vol.46 , pp. 199-208
    • Konstantinidis, D.1    Paletas, K.2    Koliakos, G.3    Kaloyianni, M.4
  • 13
    • 73349134989 scopus 로고    scopus 로고
    • Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study
    • Njajou OT, Kanaya AM, Holvoet P, Connelly S, Strotmeyer ES, Harris TB, et al. Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study. Diabetes Metab Res Rev 2009;25:733-9.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 733-739
    • Njajou, O.T.1    Kanaya, A.M.2    Holvoet, P.3    Connelly, S.4    Strotmeyer, E.S.5    Harris, T.B.6
  • 14
    • 79960561967 scopus 로고    scopus 로고
    • Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients
    • Chakraborty A, Chowdhury S, Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract 2011;93:56-62.
    • (2011) Diabetes Res Clin Pract , vol.93 , pp. 56-62
    • Chakraborty, A.1    Chowdhury, S.2    Bhattacharyya, M.3
  • 15
    • 61349099439 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2009;32(Suppl 1):S62-7.
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 1
  • 16
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 17
    • 77949493588 scopus 로고    scopus 로고
    • Leptin and adiponectin: From energy and metabolic dysbalance to inflammation and autoimmunity
    • Stofkova A. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocr Regul 2009;43:157-68.
    • (2009) Endocr Regul , vol.43 , pp. 157-168
    • Stofkova, A.1
  • 19
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
    • Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997;138:4489-92.
    • (1997) Endocrinology , vol.138 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 20
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 2006;116:1776-83.
    • (2006) J Clin Invest , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 21
    • 78049439559 scopus 로고    scopus 로고
    • Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants
    • Epub 2010 May 12
    • Sarigianni M, Bekiari E, Tsapas A, Kaloyianni M, Koliakos G, Paletas K. Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants. Angiology 2010;61:768-74. Epub 2010 May 12.
    • (2010) Angiology , vol.61 , pp. 768-774
    • Sarigianni, M.1    Bekiari, E.2    Tsapas, A.3    Kaloyianni, M.4    Koliakos, G.5    Paletas, K.6
  • 22
    • 66649118881 scopus 로고    scopus 로고
    • Altered plasma adipokines and markers of oxidative stress suggest increased risk of cardiovascular disease in first Nation youth with obesity or type 2 diabetes mellitus
    • Epub 2008 Oct 19
    • Stringer DM, Sellers EA, Burr LL, Taylor CG. Altered plasma adipokines and markers of oxidative stress suggest increased risk of cardiovascular disease in first Nation youth with obesity or type 2 diabetes mellitus. Pediatr Diabetes 2009;10:269-77. Epub 2008 Oct 19.
    • (2009) Pediatr Diabetes , vol.10 , pp. 269-277
    • Stringer, D.M.1    Sellers, E.A.2    Burr, L.L.3    Taylor, C.G.4
  • 23
    • 77955921434 scopus 로고    scopus 로고
    • Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT
    • Epub 2010 Jun 8
    • Kassi E, Dalamaga M, Hroussalas G, Kazanis K, Merantzi G, Zachari A, et al. Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT. Maturitas 2010;67:72-7. Epub 2010 Jun 8.
    • (2010) Maturitas , vol.67 , pp. 72-77
    • Kassi, E.1    Dalamaga, M.2    Hroussalas, G.3    Kazanis, K.4    Merantzi, G.5    Zachari, A.6
  • 24
    • 34250770617 scopus 로고    scopus 로고
    • Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome
    • Epub 2007 Apr 25
    • Demirel F, Bideci A, Cinaz P, Camurdan MO, Biberoglu G, Yesilkaya E, et al. Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2007;67:129-34. Epub 2007 Apr 25.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 129-134
    • Demirel, F.1    Bideci, A.2    Cinaz, P.3    Camurdan, M.O.4    Biberoglu, G.5    Yesilkaya, E.6
  • 25
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394:897-901.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 26
    • 33750964853 scopus 로고    scopus 로고
    • Leptin and resistin levels in serum of patients with hematologic malignancies: Correlation with clinical characteristics
    • Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O. Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol 2006;28:241-4.
    • (2006) Exp Oncol , vol.28 , pp. 241-244
    • Pamuk, G.E.1    Demir, M.2    Harmandar, F.3    Yesil, Y.4    Turgut, B.5    Vural, O.6
  • 28
    • 53949103666 scopus 로고    scopus 로고
    • Leptin, and stressinduced thymic atrophy
    • Epub 2008 May 21
    • Gruver AL, Sempowski GD. Cytokines, leptin, and stressinduced thymic atrophy. J Leukoc Biol 2008;84:915-23. Epub 2008 May 21.
    • (2008) J Leukoc Biol , vol.84 , pp. 915-923
    • Gruver, A.L.1    Cytokines, S.G.D.2
  • 32
    • 77955364146 scopus 로고    scopus 로고
    • Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice
    • DOI: 10.1155/2010/784343
    • Sainz N, Rodriguez A, Catalan V, Becerril S, Ramirez B, Gomez-Ambrosi J, et al. Leptin administration downregulates the increased expression levels of genes related to oxidative stress and inflammation in the skeletal muscle of ob/ob mice. Mediators Inflamm 2010;30. DOI: 10.1155/2010/784343.
    • (2010) Mediators Inflamm , pp. 30
    • Sainz, N.1    Rodriguez, A.2    Catalan, V.3    Becerril, S.4    Ramirez, B.5    Gomez-Ambrosi, J.6
  • 33
    • 77953646802 scopus 로고    scopus 로고
    • Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice
    • Epub 2010 May 19
    • Vernooy JH, Bracke KR, Drummen NE, Pauwels NS, Zabeau L, van Suylen RJ, et al. Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol 2010;184:7169-77. Epub 2010 May 19.
    • (2010) J Immunol , vol.184 , pp. 7169-7177
    • Vernooy, J.H.1    Bracke, K.R.2    Drummen, N.E.3    Pauwels, N.S.4    Zabeau, L.5    van Suylen, R.J.6
  • 36
    • 22744443610 scopus 로고    scopus 로고
    • Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: Study from Mumbai, Western India
    • Marita AR, Sarkar JA, Rane S. Type 2 diabetes in non-obese Indian subjects is associated with reduced leptin levels: study from Mumbai, Western India. Mol Cell Biochem 2005;275: 143-51.
    • (2005) Mol Cell Biochem , vol.275 , pp. 143-151
    • Marita, A.R.1    Sarkar, J.A.2    Rane, S.3
  • 38
    • 34547232648 scopus 로고    scopus 로고
    • Low serum leptin predicts mortality in patients with chronic kidney disease stage 5
    • Scholze A, Rattensperger D, Zidek W, Tepel M. Low serum leptin predicts mortality in patients with chronic kidney disease stage 5. Obesity (Silver Spring) 2007;15:1617-22.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 1617-1622
    • Scholze, A.1    Rattensperger, D.2    Zidek, W.3    Tepel, M.4
  • 39
    • 0035096596 scopus 로고    scopus 로고
    • Leptin is a negative acute phase protein in chronic hemodialysis patients
    • Don BR, Rosales LM, Levine NW, Mitch W, Kaysen GA. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int 2001;59:1114-20.
    • (2001) Kidney Int , vol.59 , pp. 1114-1120
    • Don, B.R.1    Rosales, L.M.2    Levine, N.W.3    Mitch, W.4    Kaysen, G.A.5
  • 40
    • 0034891834 scopus 로고    scopus 로고
    • Improved glycemic control increases fasting plasma acylation-stimulating protein and decreases leptin concentrations in type II diabetic subjects
    • Ozata M, Gungor D, Turan M, Ozisik G, Bingol N, Ozgurtas T, et al. Improved glycemic control increases fasting plasma acylation-stimulating protein and decreases leptin concentrations in type II diabetic subjects. J Clin Endocrinol Metab 2001;86: 3659-64.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3659-3664
    • Ozata, M.1    Gungor, D.2    Turan, M.3    Ozisik, G.4    Bingol, N.5    Ozgurtas, T.6
  • 41
    • 67349257934 scopus 로고    scopus 로고
    • The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease
    • Epub 2008 Oct 7
    • Nar A, Gedik O. The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. Acta Diabetol 2009;46:113-8. Epub 2008 Oct 7.
    • (2009) Acta Diabetol , vol.46 , pp. 113-118
    • Nar, A.1    Gedik, O.2
  • 44
  • 45
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
    • Cusi K, Consoli A, DeFronzo RA. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1996;81: 4059-67.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4059-4067
    • Cusi, K.1    Consoli, A.2    Defronzo, R.A.3
  • 46
    • 33644766950 scopus 로고    scopus 로고
    • Oxidative stress in type 2 diabetes: The role of fasting and postprandial glycaemia
    • Wright Jr E, Scism-Bacon JL, Glass LC. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract 2006;60:308-14.
    • (2006) Int J Clin Pract , vol.60 , pp. 308-314
    • Wright, E.1    Scism-Bacon, J.L.2    Glass, L.C.3
  • 47
    • 33749468032 scopus 로고    scopus 로고
    • Reduced antioxidant potential & sensitivity to oxidation in plasma low density lipoprotein fraction in type 2 diabetes mellitus patients
    • Erguder IB, Karagenc N, Karaca L. Reduced antioxidant potential & sensitivity to oxidation in plasma low density lipoprotein fraction in type 2 diabetes mellitus patients. Indian J Med Res 2006;124:207-10.
    • (2006) Indian J Med Res , vol.124 , pp. 207-210
    • Erguder, I.B.1    Karagenc, N.2    Karaca, L.3
  • 48
    • 0028286519 scopus 로고
    • Stimulation of lowdensity lipoprotein oxidation by insulin and insulin like growth factor I
    • Rifici VA, Schneider SH, Khachadurian AK. Stimulation of lowdensity lipoprotein oxidation by insulin and insulin like growth factor I. Atherosclerosis 1994;107:99-108.
    • (1994) Atherosclerosis , vol.107 , pp. 99-108
    • Rifici, V.A.1    Schneider, S.H.2    Khachadurian, A.K.3
  • 49
    • 0031806388 scopus 로고    scopus 로고
    • Relationship between insulin resistance and partially oxidized LDL particles in healthy, nondiabetic volunteers
    • Carantoni M, Abbasi F, Warmerdam F, Klebanov M, Wang PW, Chen YD, et al. Relationship between insulin resistance and partially oxidized LDL particles in healthy, nondiabetic volunteers. Arterioscler Thromb Vasc Biol 1998;18:762-7.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 762-767
    • Carantoni, M.1    Abbasi, F.2    Warmerdam, F.3    Klebanov, M.4    Wang, P.W.5    Chen, Y.D.6
  • 50
    • 34547639301 scopus 로고    scopus 로고
    • Does metformin prevent short-term oxidant-induced dna damage? In vitro study on lymphocytes from aged subjects
    • Kanigur-Sultuybek G, Ozdas SB, Curgunlu A, Tezcan V, Onaran I. Does metformin prevent short-term oxidant-induced dna damage? In vitro study on lymphocytes from aged subjects. J Basic Clin Physiol Pharmacol 2007;18:129-40.
    • (2007) J Basic Clin Physiol Pharmacol , vol.18 , pp. 129-140
    • Kanigur-Sultuybek, G.1    Ozdas, S.B.2    Curgunlu, A.3    Tezcan, V.4    Onaran, I.5
  • 51
    • 50049125341 scopus 로고    scopus 로고
    • Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes
    • Correia S, Carvalho C, Santos MS, Proenca T, Nunes E, Duarte AI, et al. Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem 2008;4: 358-64.
    • (2008) Med Chem , vol.4 , pp. 358-364
    • Correia, S.1    Carvalho, C.2    Santos, M.S.3    Proenca, T.4    Nunes, E.5    Duarte, A.I.6
  • 52
    • 54049100065 scopus 로고    scopus 로고
    • Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
    • Epub 2008 Jul 18
    • Matsumoto T, Noguchi E, Ishida K, Kobayashi T, Yamada N, Kamata K. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes. Am J Physiol Heart Circ Physiol 2008;295:H1165-76. Epub 2008 Jul 18.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Matsumoto, T.1    Noguchi, E.2    Ishida, K.3    Kobayashi, T.4    Yamada, N.5    Kamata, K.6
  • 53
    • 77951911191 scopus 로고    scopus 로고
    • Protective effects of metformin on low-density lipoprotein-induced endothelial dysfunction in rats
    • Xie W, Zhang SD, Ou XP, Yang TL. Protective effects of metformin on low-density lipoprotein-induced endothelial dysfunction in rats. Nan Fang Yi Ke Da Xue Xue Bao 2009;29: 890-3.
    • (2009) Nan Fang Yi Ke Da Xue Xue Bao , vol.29 , pp. 890-893
    • Xie, W.1    Zhang, S.D.2    Ou, X.P.3    Yang, T.L.4
  • 54
    • 40749143091 scopus 로고    scopus 로고
    • Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects
    • Formoso G, De Filippis EA, Michetti N, Di Fulvio P, Pandolfi A, Bucciarelli T, et al. Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. Diabetes Metab Res Rev 2008;24:231-7.
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 231-237
    • Formoso, G.1    de Filippis, E.A.2    Michetti, N.3    di Fulvio, P.4    Pandolfi, A.5    Bucciarelli, T.6
  • 55
    • 77951183729 scopus 로고    scopus 로고
    • Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin
    • Rabbani N, Chittari MV, Bodmer CW, Zehnder D, Ceriello A, Thornalley PJ. Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin. Diabetes 2010;59:1038-45.
    • (2010) Diabetes , vol.59 , pp. 1038-1045
    • Rabbani, N.1    Chittari, M.V.2    Bodmer, C.W.3    Zehnder, D.4    Ceriello, A.5    Thornalley, P.J.6
  • 56
    • 0038177982 scopus 로고    scopus 로고
    • Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats
    • Iida KT, Kawakami Y, Suzuki M, Shimano H, Toyoshima H, Sone H, et al. Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats. Am J Physiol Endocrinol Metab 2003;284:E1125-30.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Iida, K.T.1    Kawakami, Y.2    Suzuki, M.3    Shimano, H.4    Toyoshima, H.5    Sone, H.6
  • 57
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167-74.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6
  • 58
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kappaB: Players, pathways, perspectives
    • Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 2006;25:6680-4.
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 59
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 60
    • 77953739658 scopus 로고    scopus 로고
    • Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro
    • Arai M, Uchiba M, Komura H, Mizuochi Y, Harada N, Okajima K. Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro. J Pharmacol Exp Ther 2010;334:206-13.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 206-213
    • Arai, M.1    Uchiba, M.2    Komura, H.3    Mizuochi, Y.4    Harada, N.5    Okajima, K.6
  • 61
    • 67650753558 scopus 로고    scopus 로고
    • Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients
    • Vasconcelos EM, Degasperi GR, de Oliveira HC, Vercesi AE, de Faria EC, Castilho LN. Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients. Clin Biochem 2009;42:1222-7.
    • (2009) Clin Biochem , vol.42 , pp. 1222-1227
    • Vasconcelos, E.M.1    Degasperi, G.R.2    de Oliveira, H.C.3    Vercesi, A.E.4    de Faria, E.C.5    Castilho, L.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.