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Volumn 18, Issue 2, 2007, Pages 129-140

does metformin prevent short term oxidant-induced dna damage? in vitro study on lymphocytes from aged subjects

Author keywords

comet assay; DNA damage; lymphocyte; metformin; oxidative stress

Indexed keywords

CELL DNA; DNA FRAGMENT; METFORMIN; OXIDIZING AGENT;

EID: 34547639301     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.2007.18.2.129     Document Type: Article
Times cited : (21)

References (33)
  • 3
    • 0024366182 scopus 로고
    • Mutagenesis and carcinogenesis; endogenous and exogenous factors
    • Suppl 16
    • Ames, BN. Mutagenesis and carcinogenesis; endogenous and exogenous factors. Environ Mol Mutagen 1989;14 Suppl 16:66–77.
    • (1989) Environ Mol Mutagen , vol.14 , pp. 66-77
    • Ames, B.N.1
  • 4
    • 0037194640 scopus 로고    scopus 로고
    • Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes
    • Dincer, Y, Akcay, T, Alademir, Z and Ilkova, H. Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes. Mutat Res 2002;29:75–81.
    • (2002) Mutat Res , vol.29 , pp. 75-81
    • Dincer, Y.1    Akcay, T.2    Alademir, Z.3    Ilkova, H.4
  • 5
    • 0043011500 scopus 로고    scopus 로고
    • Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes
    • Pitozzi, V, Giovannelli, L, Bardini, G, Rotella, CM and Dolara, P. Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes. Mutat Res 2003;529:129–33.
    • (2003) Mutat Res , vol.529
    • Pitozzi, V.1    Giovannelli, L.2    Bardini, G.3    Rotella, C.M.4    Dolara, P.5
  • 6
    • 0042093769 scopus 로고    scopus 로고
    • New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy
    • Ceriello, A: New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care 2003;26:1589–96.
    • (2003) Diabetes Care , vol.26
    • Ceriello, A.1
  • 7
    • 18144451494 scopus 로고    scopus 로고
    • Beneficial effects of metformin on haemostasis and vascular function in man
    • Grant, PJ. Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab 2003;29:6844–52.
    • (2003) Diabetes Metab , vol.29
    • Grant, P.J.1
  • 8
    • 0034086934 scopus 로고    scopus 로고
    • Metformin: intrinsic vasculoprotective properties
    • Wiemsperger, NF. Metformin: intrinsic vasculoprotective properties. Diabetes Technol Ther 2000;2:259–72.
    • (2000) Diabetes Technol Ther , vol.2
    • Wiemsperger, N.F.1
  • 9
    • 0033008628 scopus 로고    scopus 로고
    • An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats
    • Faure, P, Rossini, E, Wiemsperger, N, Richard, MJ, Favier, A, Halimi, S. An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats. Diabetes 1999;48: 353–57.
    • (1999) Diabetes , vol.48
    • Faure, P.1    Rossini, E.2    Wiemsperger, N.3    Richard, M.J.4    Favier, A.5    Halimi, S.6
  • 11
    • 0038410183 scopus 로고    scopus 로고
    • An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress
    • Bonnefont-Rousselot, D, Raji, B, Walrand, S, Gardes-Albert, M, Jore, D, Legrand, A, et al. An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 2003;52:586–89.
    • (2003) Metabolism , vol.52
    • Bonnefont-Rousselot, D.1    Raji, B.2    Walrand, S.3    Gardes-Albert, M.4    Jore, D.5    Legrand, A.6
  • 12
    • 33751192093 scopus 로고    scopus 로고
    • Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress
    • Onaran, I, Guven, GS., Ozdaş, SB, Kanigur, G, Vehid, S. Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress. Mutat Res 2006;611:1–8.
    • (2006) Mutat Res , vol.611 , pp. 1-8
    • Onaran, I.1    Guven, G.S.2    Ozdaş, S.B.3    Kanigur, G.4    Vehid, S.5
  • 14
    • 0024343128 scopus 로고
    • DNA damage and repair during cellular aging
    • Rattan, SI. DNA damage and repair during cellular aging. Int Rev Cytol 1989;116:47–88.
    • (1989) Int Rev Cytol , vol.116 , pp. 47-88
    • Rattan, S.I.1
  • 15
    • 0029891679 scopus 로고    scopus 로고
    • Correlation between age and DNA damage detected by FADU in human peripheral blood lymphocytes
    • Chicca, MC, Nesti, C, Muzzoli, M, Pasetti, P and Pinamonti, S. Correlation between age and DNA damage detected by FADU in human peripheral blood lymphocytes. Mutat Res 1996;316:201–8.
    • (1996) Mutat Res , vol.316
    • Chicca, M.C.1    Nesti, C.2    Muzzoli, M.3    Pasetti, P.4    Pinamonti, S.5
  • 18
    • 0032511210 scopus 로고    scopus 로고
    • Simple high-performance liquid chromatographic method for the determination of metformin in human plasma
    • Yuen, KH, Khiang, PK. Simple high-performance liquid chromatographic method for the determination of metformin in human plasma. J Chromatogr B Biomed Sci 1998:12;243–46.
    • (1998) J Chromatogr B Biomed Sci , vol.12
    • Yuen, K.H.1    Khiang, P.K.2
  • 19
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh, NP, McCoy, MT, Tice, RR, Schneider, E. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184–91.
    • (1988) Exp Cell Res , vol.175
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.4
  • 20
    • 0029102911 scopus 로고
    • The single cell gel electrophoresis/comet assay: a potential tool for detecting radiation-induced DNA damage in humans
    • Tice, RR, Strauss, GH. The single cell gel electrophoresis/comet assay: a potential tool for detecting radiation-induced DNA damage in humans. Stem Cells 1995;13 Suppl 1:207–14.
    • (1995) Stem Cells , vol.13
    • Tice, R.R.1    Strauss, G.H.2
  • 21
    • 0028305534 scopus 로고
    • The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the Comet assay
    • Anderson, D, Yu, TW, Phillips, BJ. Schmerzer, P. The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the Comet assay. Mutat Res 1994;30:261–71.
    • (1994) Mutat Res , vol.30
    • Anderson, D.1    Yu, T.W.2    Phillips, B.J.3    Schmerzer, P.4
  • 22
    • 0037052816 scopus 로고    scopus 로고
    • Basal levels of DNA strand breaks in human leukocytes determined by comet assay
    • Diem, E, Ivancsits, S, Rudiger, HW: Basal levels of DNA strand breaks in human leukocytes determined by comet assay. J Toxicol Environ Health 2002;65:641–8.
    • (2002) J Toxicol Environ Health , vol.65
    • Diem, E.1    Ivancsits, S.2    Rudiger, H.W.3
  • 23
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei, YH. Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med 1998;217:53–63.
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 26
    • 0038204747 scopus 로고    scopus 로고
    • Age related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects
    • Mutlu-Turkoglu, U, Ilhan, E, Oztezcan, S, Kuru, A, Aykac-Toker, G, Uysal, M: Age related increases in plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in elderly subjects. Clin Biochem 2003;36:397–400.
    • (2003) Clin Biochem , vol.36 , pp. 397-400
    • Mutlu-Turkoglu, U.1    Ilhan, E.2    Oztezcan, S.3    Kuru, A.4    Aykac-Toker, G.5    Uysal, M.6
  • 27
    • 0032955553 scopus 로고    scopus 로고
    • Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
    • Mecocci, P, Fano, G, Fulle, S, MacGarvey, U, Shinobu, L, Polidori, MC, et al. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med 1999;26:303–8.
    • (1999) Free Radic Biol Med , vol.26
    • Mecocci, P.1    Fano, G.2    Fulle, S.3    MacGarvey, U.4    Shinobu, L.5    Polidori, M.C.6
  • 29
    • 0003649112 scopus 로고
    • Development, aging and disease
    • Chur, Switzerland: Harwood Academic Publishers
    • Dilman, VM. Development, aging and disease. A new rationale for an intervention. Chur, Switzerland: Harwood Academic Publishers, 1994
    • (1994) A new rationale for an intervention
    • Dilman, V.M.1
  • 30
    • 0038410183 scopus 로고    scopus 로고
    • An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress
    • Bonnefont-Rousselot, D, Raji, B, Walrand, S, Gardes-Albert, M, Jore, D, Legrand, A, et al. An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 2003;52:586–89.
    • (2003) Metabolism , vol.52
    • Bonnefont-Rousselot, D.1    Raji, B.2    Walrand, S.3    Gardes-Albert, M.4    Jore, D.5    Legrand, A.6
  • 31
    • 0035930399 scopus 로고    scopus 로고
    • Formation of DNA adducts by microsomal and peroxidase activation of p-cresol: role of quinone methide in DNA adduct formation
    • Gaikwad, NW, Bodell, WJ. Formation of DNA adducts by microsomal and peroxidase activation of p-cresol: role of quinone methide in DNA adduct formation. Chem Biol Interac 2001;38:217–29.
    • (2001) Chem Biol Interac , vol.38
    • Gaikwad, N.W.1    Bodell, W.J.2
  • 32
    • 8744272467 scopus 로고    scopus 로고
    • Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    • Marchetti, P, Del Guerra, S, Marselli, L, Lupi, R, Masini, M, Pollera, M, et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 2004;89:5535–41.
    • (2004) J Clin Endocrinol Metab , vol.89
    • Marchetti, P.1    Del Guerra, S.2    Marselli, L.3    Lupi, R.4    Masini, M.5    Pollera, M.6
  • 33
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex, I
    • El-Mir, MY, Nogueira, V, Fontaine, E, Avéret, N, Rigoulet, M, Leverve, X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex, I. J Biol Chem 2000;275: 223–8.
    • (2000) J Biol Chem , vol.275
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Avéret, N.4    Rigoulet, M.5    Leverve, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.