High-throughput-screening-based identification and structure-activity relationship characterization defined (S)-2-(1-aminoisobutyl)-1-(3-chlorobenzyl) benzimidazole as a highly antimycotic agent nontoxic to cell lines

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6993-6997

  Bauer, Jörg ^a   Kinast, Stephan ^a   Burger Kentischer, Anke ^b   Finkelmeier, Doris ^b   Kleymann, Gerald ^c   Rayyan, Walid Abu ^c   Schröppel, Klaus ^c   Singh, Anurag ^c   Jung, Günther ^a   Wiesmüller, Karl Heinz ^a   Rupp, Steffen ^b   Eickhoff, Holger ^a  

^a EMC MICROCOLLECTIONS GMBH   (Germany)

^b FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 AMINOISOBUTYL) 1 (3 CHLOROBENZYL)BENZIMIDAZOLE; ANTIFUNGAL AGENT; BENZIMIDAZOLE DERIVATIVE; FLUCONAZOLE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; DRUG EFFICACY; DRUG SELECTIVITY; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ANTIMITOTIC AGENTS; BENZIMIDAZOLES; CANDIDA; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MYCOLOGY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 80053916199     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200571e     Document Type: Article

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