Formation of azole-resistant Candida albicans by mutation of sterol 14- demethylase P450

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 5, 1999, Pages 1163-1169

  Asai, Kentaro ^a   Tsuchimori, Noboru ^a   Okonogi, Kenji ^a   Perfect, John R ^b   Gotoh, Osamu ^c   Yoshida, Yuzo ^d  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c SAITAMA CANCER CENTER   (Japan)

^d MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; ERGOSTEROL; FLUCONAZOLE; MEVALONIC ACID; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CASE REPORT; DNA POLYMORPHISM; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME ASSAY; GENE ISOLATION; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0032930848     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1163     Document Type: Article

References (34)

1. Albertson, G. D., M. Niimi, R D. Cannon, and H. F. Jenkinson. 1996. Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance. J. Antimicrob. Chemother. 40:2835-2841.
2. Aoyama, Y., M. Noshiro, O. Gotoh, S. Imaoka, Y. Funae, N. Kurosawa, T. Horiuchi, and Y. Yoshida. 1996. Sterol 14-demethylase F450 (P45014DM) is one of the most ancient and conserved P450 species. J. Biochem. 119:926-933.
3. Aoyama, Y., Y. Yoshida, and R. Sato. 1984. Yeast cytochrome P-450 catalyzing lanosterol 14α-demethylation. J. Biol. Chem. 259:1661-1666.
4. Balan, I., A.-M. Alarco, and M. Raymond. 1997. The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter. J. Bacteriol. 179:7210-7218.
5. Barrett-Bee, K. J., A. C. Lane, and R. W. Turner. 1986. The mode of antifungal action of tolnaftate. J. Med. Vet. Mycol. 24:155-160.
6. Délye, C., F. Laigret, and M.-F. Corio-Costet. 1997. A mutation in the 14α-demethylase gene of Uncinula necator that correlates with resistance to a sterol biosynthesis inhibitor. Appl. Environ. Microbiol. 63:2966-2970.
7. Diener, A. C., and G. R. Fink. 1996. DLH1 is a functional Candida albicans homologue of the meiosis-spedfic gene DMC1. Genetics 143:769-776.
8. Franz, R., S. L. Kelly, D. C. Lamb, D. E. Kelly, M. Ruhnke, and J. Morschhäuser. 1998. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob. Agents Chemother. 42:3065-3072.
9. Gotoh, O. 1992 Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267:83-90.
10. Gräser, Y., M. Volovsek, J. Arrington, G. Schönian, W. Presber, T. G. Mitchell, and R. Vilgalys. 1996. Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination. Proc. Natl. Acad. Sci. USA 93:12473-12477.
11. Hawser, S. P., and L. J. Douglas. 1995. Resistance of Candida albicans biofilms to antifungal agents in vitro. Antimicrob. Agents Chemother. 39: 2128-2131.
12. Hitchcock, C. A., K. J. Barrett-Bee, and N. J. Russell. 1986. The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans. J. Gen. Microbiol. 132:2421-2431.
13. Hooper, D. C., and J. S. Wolfson. 1991. Mode of action of the new quinolones: new data. Eur. J. Clin. Microbiol. Infect. Dis. 10:223-231.
14. Hoyer, L. L., S. Scherer, A. R. Shatzman, and G. P. Livi. 1995. Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif. Mol. Microbiol. 15:39-54.
15. Johnson, E. M., D. W. Warnock, J. Luker, S. R. Porter, and C. Scully. 1995. Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis. J. Antimicrob. Chemother. 35:103-114.
16. 5,6-desaturation. FEBS Lett. 400:80-82.
17. Lai, M. H., and D. R Kirsch. 1989. Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14α-demethylase) from Candida albicans. Nucleic Acids Res. 17:804.
18. Lamb, D. C., D. E. Kelly, W.-H. Schunck, A. Z. Shyadehi, M. Akhtar, D. J. Lowe, B. C. Baldwin, and S. L. Kelly. 1997. The mutation T315K in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. J. Biol. Chem. 272:5682-5688.
19. Löffler, J., S. L. Kelly, H. Hebart, U. Schumacher, C. Lass-Flörl, and H. Einsele. 1997. Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains. FEMS Microbiol. Lett. 151:263-268.
20. National Committee for Clinical Laboratory Standards. 1992. Reference method for broth dilution antifungal susceptibility testing of yeasts. Proposed standard document M27-P. National Committee for Clinical Laboratory Standards, Villanova, Pa.
21. Omura, T., and R. Sato. 1964, The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239:2370-2378.
22. Pujol, C., J. Reynes, F. Renaud, M. Raymond, M. Tibayrenc, F. J. Ayala, F. Janbon, M. Mallie, and J.-M. Bastide. 1993. The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients. Proc. Natl. Acad. Sci. USA 90:9456-9459.
23. Revankar, S. G., W. R. Kirkpatrick, R. K. McAtee, O. P. Dib, A. W. Fothergill, S. W. Redding, M. G. Rinaldi, and T. F. Patterson. 1996. Detection and significance of fluconazole resistance in oropharyngeal candidiasis in human immunodeficiency virus-infected patients. J. Infect. Dis. 174:821-827.
24. Rex, J. H, M. G. Rinaldi, and M. A. Pfaller. 1995. Resistance of Candida species to fluconazole. Antimicrob. Agent Chemother. 39:1-8.
25. Rybkine, T., J.-L. Mainardi, W. Sougakoff, E. Collatz, and L. Gutmann. 1998. Penicillin-binding protein 5 sequence alterations in clinical isolates of Enterococcus faecium with different levels of β-lactam resistance. J. Infect. Dis. 178:159-163.
26. Sanglant, D., F. Ischer, L. Koymans, and J. Bille. 1998. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob. Agents Chemother. 42:241-253.
27. Sanglant, D., K. Kuchler, F. Ischer, J.-L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
28. Tibayrenc, M. 1997. Are Candida albicans natural populations subdivided? Trends Microbiol. 5:253-257.
29. Tibayrenc, M., F. Kjellberg, J. Arnaud, B. Oury, S. F. Breniere, M.-L. Darde, and F. J. Ayala. 1991. Are eukaryotic microorganisms clonal or sexual? A population genetics vantage. Proc. Natl. Acad. Sci. USA 88:5129-5133.
30. White, T. C. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
31. White, T. C. 1997. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans. Antimicrob. Agents Chemother. 41:1488-1494.
32. Yoshida, T., K. Jono, and K. Okonogi. 1997. Modified agar dilution susceptibility testing method for determining in vitro activities of antifungal agents, including azole compounds. Antimicrob. Agents Chemother. 41:1349-1351.
33. Yoshida, Y. 1988. Cytochrome P450 of fungi: primary target for azole antifungal agents, p. 388-418. In M. R. McGinnis (ed.), Current topics in medical mycology, vol. 2. Springer-Verlag, New York, N.Y.
34. 14DM from yeast. Chirality 2:10-15.