Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury

Toxicology and Industrial Health

Volumn 23, Issue 7, 2007, Pages 403-410

  Xu, Zhaofa ^a   Yang, Jinghua ^a   Yu, Jiaming ^a   Yin, Zhongwei ^a   Sun, Wei ^a   Li, Jing ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

buthionine sulfoximine; gluthionein; mercury; nephrotoxicity; sodium 2,3 dimercato 1 propanesulfonate; vitamin C

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALKALINE PHOSPHATASE; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; GLUTATHIONE; LACTATE DEHYDROGENASE; PROTEIN; UNITHIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; KIDNEY CORTEX; KIDNEY FUNCTION; LIVER; MALE; MERCURIALISM; NEPHROTOXICITY; NONHUMAN; PROTEINURIA; RAT; UREA NITROGEN BLOOD LEVEL; URINE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; GLUTATHIONE; KIDNEY CORTEX; KIDNEY DISEASES; LIVER; MALE; MERCURIC CHLORIDE; MERCURY POISONING; RATS; RATS, WISTAR; UNITHIOL;

RATTUS;

EID: 43449126512     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233707077431     Document Type: Article

References (22)

1. Adair, B.M. and Cobb, G.P. 1999: Improved preparation of small biological samples for mercury analysis using cold vapor atomic absorption spectroscopy. Chemosphere 38, 2951—58.
2. Aposhian, H.V., Morgan, D.L., Queen, H.L. et al. 2003: Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor. Toxicol Clin Toxicol 41, 339—47.
3. Baggett, J.M. and Berndt, W.O. 1986: The effect of depletion of non-protein sulhydryls by diethyl meleate plus buthionine sulfoximine on the renal uptake of mercury in the rats. Toxicol Appl Pharmacol 83, 556—62.
4. Bazzi, C., Petrini, C., Rizza, V. et al. 2002: Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a predictor of outcome in primary glomerulonephritis. Nephrol Dial Transplant 17, 1890—96.
5. Bradford, M.M. 1976: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Analytical Biochemistry 72, 248—54.
6. Ceaurriz, J. and Payan, J.P. 1994: Role of extracellular glutathione and g-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. Appl Toxicol 14, 201—206.
7. Heinegard, D. and Tiderstrom, G. 1973: Determination of serum creatinine by a direct colorimetric method. Clinica Chimica Acta 43, 305—10.
8. Henneman, P.L., Bar'Or, D. and Marx, J.A. 1988: Urinary lactic dehydrogenase as a marker of renal injury in blunt trauma patients with hematuria. Ann Emerg Med 17, 797—800.
9. Hussain, S. 1999: Accumulation of mercury and its effect on antioxidant enzymes in brain, liver, and kidneys of mice. J Environ Sci Health B 34, 645—60.
10. Johnston, I.D., Jones, N.F., Scoble, J.E. et al. 1983: The diagnostic value of urinary enzyme measurements in hypertension. Clin Chim Acta 133, 317—25.
11. Kim, C.Y., Watanabe, C., Satoh, H. et al. 1995: Effects of buthionine sulfoximine (BSO) on mercury distribution after Hg (o) exposure. Toxicology 98, 67—72.
12. Kyle, G.M., Luthra, R., Bruckner, J.V. et al. 1983: Assessment of functional, morphological, and enzymatic tests for acute nephrotoxicity induced by mercuric chloride. J Toxicol Environ Health 12, 99—117.
13. Noroozi, M., Angerson, W.J., Lean, M.E. et al. 1998: Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. Clin Nutr 67, 1210—18.
14. Pingree, S.D. and Simmonds, P.L. 2001: Effects of 2, 3-dimercapto-1- propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats. Toxicol Sci 61, 224—33.
15. Price, R.G. 1982: Urinary enzymes, nephrotoxicity and renal diseases. Toxicology 23: 99—101.
16. Rankin, G.O., Beers, K.W., Teets, V.J. et al. 1997: Buthionine sulfoximine (BSO) and N-(3,5-dichlorophenyl) succinimide nephrotoxicity: temporal aspects of BSO administration and BSO effects on renal transport systems. Toxicology 117, 207—17.
17. Rao, M.V., Chinoy, N.J., Suthar, M.B. et al. 2001: Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures. Toxicol In Vitro 15, 649—54.
18. Stacchiotti, A., Borsani, E., Rodella, L. et al. 2003: Dose-dependent mercuric chloride tubular injury in rat kidney. Ultrastruct Pathol 27, 253—59.
19. Watanabe, T., Sagisaka, H., Arakawa, S. et al. 2003: A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S,R)-sulfoximine. J Toxicol Sci 28, 455—69.
20. Zalups, R.K. 2001: Molecular interactions with mercury in the kidney. Pharmacol Rev 52, 126—31.
21. Zalups, R.K. and Barfuss, D.W. 1996: Nephrotoxicity of inorganic mercury co-administrated with L-cysteine. Toxicology 109, 15—29.
22. Zalups, R.K. and Lash, L.H. 1997: Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. Drug Metab Dispos 25, 516—23.