Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 39, 2011, Pages 16434-16439

  Zhang, Peisu ^a   Casaday Potts, Rebecca ^a   Precht, Patricia ^a   Jiang, Haiyang ^a   Liu, Yie ^a   Pazin, Michael J ^a   Mattson, Mark P ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Alternative splicing; Brain development; Cajal Retzius cells; Proteasomal degradation; Re1 element

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLUTAMATE RECEPTOR 2; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; PROTEIN MYB; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; SHORT HAIRPIN RNA; TELOMERIC REPEAT BINDING FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL FRACTIONATION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE REPRESSION; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; BRAIN; GENE SILENCING; HUMANS; MOLECULAR SEQUENCE DATA; NEURONS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERE; TELOMERE-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 80053628559     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106906108     Document Type: Article

References (38)

1. Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G (2005) REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121:645-657. (Pubitemid 40720016)
2. Westbrook TF, et al. (2008) SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452:370-374. (Pubitemid 351430796)
3. Lunyak VV, et al. (2002) Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298:1747-1752. (Pubitemid 35404110)
4. Sun YM, et al. (2005) Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol Biol Cell 16:5630-5638.
5. Schoenherr CJ, Anderson DJ (1995) The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 267:1360-1363.
6. Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S (2008) REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453:223-227. (Pubitemid 351667975)
7. Westbrook TF, et al. (2005) A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837-848. (Pubitemid 40806416)
8. Bruce AW, et al. (2004) Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci USA 101:10458-10463. (Pubitemid 38924947)
9. Johnson DS, Mortazavi A, Myers RM, Wold B (2007) Genome-wide mapping of in vivo protein-DNA interactions. Science 316:1497-1502. (Pubitemid 46906620)
10. Calderone A, et al. (2003) Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci 23:2112-2121. (Pubitemid 36368899)
11. Palm K, Belluardo N, Metsis M, Timmusk T (1998) Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci 18:1280-1296. (Pubitemid 28082414)
12. Jia YH, Zhu X, Li SY, Ni JH, Jia HT (2006) Kainate exposure suppresses activation of GluR2 subunit promoter in primary cultured cerebral cortical neurons through induction of RE1-silencing transcription factor. Neurosci Lett 403:103-108. (Pubitemid 43963247)
13. Garriga-Canut M, et al. (2006) 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci 9:1382-1387. (Pubitemid 44646210)
14. Zuccato C, et al. (2003) Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35:76-83. (Pubitemid 37048599)
15. Zuccato C, et al. (2007) Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J Neurosci 27:6972-6983. (Pubitemid 47015906)
16. Abrajano JJ, et al. (2009) REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS ONE 4:e7936.
17. Calarco JA, et al. (2009) Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell 138:898-910.
18. Ule J, et al. (2006) An RNA map predicting Nova-dependent splicing regulation. Nature 444:580-586. (Pubitemid 44864431)
19. Wolkowitz OM, et al. (2011) Leukocyte telomere length in major depression: Correlations with chronicity, inflammation and oxidative stress - preliminary findings. PLoS ONE 6:e17837.
20. de Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110.
21. Blanco R, Muñoz P, Flores JM, Klatt P, Blasco MA (2007) Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev 21:206-220. (Pubitemid 46155814)
22. Liu D, O'Connor MS, Qin J, Songyang Z (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem279:51338-51342. (Pubitemid 40017880)
23. Cesare AJ, et al. (2009) Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol 16:1244-1251.
24. Tanaka H, et al. (2005) DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc Natl Acad Sci USA 102:15539-15544. (Pubitemid 41528829)
25. Lam YC, et al. (2010) SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. EMBO J 29:2230-2241.
26. Giannone RJ, et al. (2010) The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS ONE 5:e12407.
27. Zhang P, et al. (2008) Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol 18:1489-1494.
28. Zhang P, et al. (2006) TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. J Neurochem 97:567-581.
29. Gunisova S, Bartosova Z, Kramara J, Nosek J, Tomaska L (2010) Formation of C-terminally truncated version of the Taz1 protein employs cleavage-box structure in mRNA. Biochem Biophys Res Commun 392:391-396.
30. Encinas M, et al. (2000) Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem 75:991-1003. (Pubitemid 30660487)
31. Hu CD, Grinberg AV, Kerppola TK (2005) Visualization of protein interactions in living cells using bimolecular fluorescence complementation (BiFC) analysis. Curr Protoc Protein Sci 41:19.10.1-19.10.21.
32. Liu H, et al. (2006) Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization. EMBO J 25:1058-1069. (Pubitemid 43372119)
33. Andrés ME, et al. (1999) CoREST: A functional corepressor required for regulation of neural-specific gene expression. Proc Natl Acad Sci USA 96:9873-9878. (Pubitemid 29398825)
34. Tissir F, Goffinet AM (2003) Reelin and brain development. Nat Rev Neurosci 4:496-505. (Pubitemid 37280170)
35. Otto SJ, et al. (2007) A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci 27:6729-6739. (Pubitemid 46983428)
36. Jothi R, Cuddapah S, Barski A, Cui K, Zhao K (2008) Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res 36:5221-5231.
37. Kim CS, et al. (2011) Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation. Biochim Biophys Acta 1783:1835-1846.
38. Gao Z, et al. (2011) Themaster negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci 31:9772-9786.