Protective effect of pyruvate against ethanol-induced apoptotic neurodegeneration in the developing rat brain

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1248-1255

  Ullah, Najeeb ^a   Naseer, Muhammad Imran ^a   Ullah, Ikram ^a   Lee, Hae Young ^a   Koh, Phil Ok ^a   Kim, Myeong Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Apoptotic neurodegeneration; Ethanol; Fetal alcohol effects; Fetal alcohol syndrome; Neuroprotection; Pyruvate

Indexed keywords

ALCOHOL; CASPASE 3; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PYRUVIC ACID;

ALCOHOL BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN; CASPASE 3; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROMES C; DISEASE MODELS, ANIMAL; ETHANOL; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; ORGANIC CHEMICALS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UP-REGULATION;

EID: 80053615952     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.031     Document Type: Article

References (57)

1. J.K. Andersen Oxidative stress in neurodegeneration: cause or consequence? Nat. Rev. Neurosci. 5 2004 S18 S25
2. K.J. Anderson, K.M. Miller, I. Fugaccia, and S.W. Scheff Regional distribution of Fluoro- Jade B staining in the hippocampus following traumatic brain injury Exp. Neurol. 193 2005 125 130 (Pubitemid 40463274)
3. T. Araki, Y. Sasaki, and J. Milbrandt Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 2004 1010 1013 (Pubitemid 39071777)
4. M.F. Beal Energetics in the pathogenesis of neurodegenerative diseases Trends Neurosci. 23 2000 298 304 (Pubitemid 30387044)
5. N.A. Berger Poly(ADP-ribose) in the cellular response to DNA damage Radiat. Res. 101 1985 4 15 (Pubitemid 15168488)
6. P. Bernardi, A. Krauskopf, E. Basso, V. Petronilli, E. Blachly-Dyson, L.F. Di, and M.A. Forte The mitochondrial permeability transition from in vitro artifact to disease target FEBS J. 273 2006 2077 2099
7. L. Burd, M.G. Klug, J.T. Martsolf, and J. Kerbeshian Fetal alcohol syndrome: neuropsychiatric phenomics Neurotoxicol. Teratol. 25 2003 697 705 (Pubitemid 37415156)
8. D.T. Chao, and S.J. Korsmeye Bcl-2 family: regulators of cell death Annu. Rev. Immunol. 16 1998 395 419 (Pubitemid 28183370)
9. J. Chu, M. Tong, M. Suzanne, and de la Monte Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons Acta Neuropathol. 113 2007 659 673 (Pubitemid 46863902)
10. K. Dikranian, M.J. Ishimaru, T. Tenkova, J. Labruyere, Y.Q. Qin, C. Ikonomidou, and J.W. Olney Apoptosis in the in vivo mammalian forebrain Neurobiol. Dis. 8 2001 359 379 (Pubitemid 32566129)
11. K. Dikranian, Y.Q. Qin, J. Labruyere, B. Nemmers, and J.W. Olney Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures Dev. Brain Res. 155 2005 1 13 (Pubitemid 40342947)
12. M.J. Eckardt, S.E. File, G.L. Gessa, K.A. Grant, C. Guerri, P.L. Hoffman, H. Kalant, G.F. Koob, T.-K. Li, and B. Tabakoff Effects of moderate alcohol consumption on the central nervous system Alcohol Clin. Exp. Res. 22 1998 998 1040 (Pubitemid 28408991)
13. M.P. Fink Ethyl pyruvate: a novel anti-inflammatory agent Crit. Care Med. 31 2003 S51 S56
14. G. Fiskum, R.E. Rosenthal, V. Vereczki, E. Martin, G.E. Hoffman, C. Chinopoulos, and A. Kowaltowski Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress J. Bioenerg. Biomembr. 36 2004 347 352 (Pubitemid 39619839)
15. A.R. Giandomenico, G.E. Cerniglia, J.E. Biaglow, C.W. Stevens, and C.J. Koch The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide Free Radic. Biol. Med. 23 1997 426 434 (Pubitemid 27276779)
16. C.R. Goodlett, K.H. Horn, and F.C. Zhou Alcohol teratogenesis: mechanisms of damage and strategies for intervention Exp. Biol. Med. 230 2005 394 406 (Pubitemid 40827704)
17. R.A. Harris, W.R. Proctor, S.J. McQuilkin, R.L. Klein, M.P. Mascia, V. Whatley, P.J. Whiting, and T.V. Dunwiddie Ethanol increases GABAA responses in cells stably transfected with receptor subunits Alcohol Clin. Exp. Res. 19 1995 226 232
18. B.R. Hu, C.L. Liu, Y. Ouyang, K. Blomgren, and B.K. Siesjo Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation J. Cereb. Blood Flow. Meta. 20 2000 1294 1300
19. C. Ikonomidou, P. Bittigau, M.J. Ishimaru, D.F. Wozniak, C. Koch, K. Genz, M.T. Price, V. Stefovska, F. Horster, T. Tenkova, K. Dikranian, and J.W. Olney Ethanol induced apoptotic neurodegeneration and fetal alcohol syndrome Science 287 2000 1056 1060 (Pubitemid 30094364)
20. C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vockler, K. Dikranian, T. Tenkova, V. Stefovska, L. Turski, and J.W. Olney Blockade of glutamate receptors triggers apoptotic neurodegeneration in the developing brain Science 283 1999 70 74 (Pubitemid 29044848)
21. K.L. Jones, and D.W. Smith Recognition of the fetal alcohol syndrome in early infancy Lancet ii 1973 999 1001
22. T. Kumada, M.K. Lakshmana, and H. Komuro Reversal of neuronal migration in a mouse model of fetal alcohol syndrome by controlling second-messenger signalings J. Neurosci. 26 2006 742 756 (Pubitemid 43237067)
23. Y.A. Lazebnik, S.H. Kaufman, S. Desnoyers, G.G. Poirier, and W.C. Earnshaw Cleavage of poly (ADP-ribose) polymerase by proteins with properties like ICE Nature 371 1994 346 347 (Pubitemid 24300618)
24. D.A. Le, Y. Wu, Z. Huang, K. Matsushita, N. Plesnila, J.C. Augustinack, B.T. Hyman, J. Yuan, K. Kuida, R.A. Flavell, and M.A. Moskowitz Caspase activation and neuroprotection in caspase-3 deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation Proc. Natl. Acad. Sci. U.S.A. 99 2002 15188 15193 (Pubitemid 35334631)
25. P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489 (Pubitemid 27508237)
26. R.T. Mallet, J. Sun, E.M. Knott, A.B. Sharma, and A.H. Olivencia-Yurvati Metabolic cardioprotection by pyruvate Exp. Biol. Med. 230 2005 435 443
27. R.T. Mallet, and R. Bunger Metabolic protection of postischemic phosphorylation potential and ventricular performance Adv. Exp. Med. Biol. 346 1993 233 241 (Pubitemid 24048729)
28. S.N. Mattson, and E.P. Riley A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol Alcohol Clin. Exp. Res. 22 1998 279 294 (Pubitemid 28208948)
29. M. Maus, P. Marin, M. Israel, J. Glowinski, and J. Premont Pyruvate and lactate protect striatal neurons against N-methyl-d-aspartate-induced neurotoxicity Eur. J. Neurosci. 11 1999 3215 3224 (Pubitemid 29431656)
30. P.D. Mongan, J.L. Fontana, R. Chen, and R. Bunger Intravenous pyruvate prolongs survival during hemorrhagic shock in swine Am. J. Physiol. 277 1999 H2253 H2263
31. S.K. Mukherjee, L.K. Klaidman, R. Yasharel, and J.D. Adams Increased brain NAD prevents neuronal apoptosis in vivo Eur. J. Pharmacol. 330 1997 27 34 (Pubitemid 27304031)
32. D.G. Nicholls, L. Johnson-Cadwell, S. Vesce, M. Jekabson, and N. Yadava Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity J. Neurosci. Res. 85 2007 3206 3212 (Pubitemid 350058509)
33. B. O'Rourke, S. Cortassa, and M.A. Aon mitochondrial ion channels: gatekeepers of life and death Physiology (Bethesda) 20 2005 303 315 (Pubitemid 41457396)
34. J.W. Olney, T. Tenkova, K. Dikranian, L.J. Muglia, W.J. Jermakowicz, C. D'Sa, and K.A. Roth Ethanol-induced caspase-3 activation in the in vivo developing mouse brain Neurobiol. Dis. 9 2002 205 219 (Pubitemid 34261215)
35. J.W. Olney, T. Tenkova, K. Dikranian, Y.Q. Qin, J. Labruyere, and C. Ikonomidou Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain Dev. Brain Res. 133 2002 115 126 (Pubitemid 34211997)
36. D.E. Phillips Effects of limited postnatal ethanol exposure on the development of myelin and nerve fibers in rat optic nerve Exp. Neurol. 107 1989 90 97
37. V. Ramachandran, L.T. Watts, S.K. Maffi, J.J. Chen, S. Schenker, and G.I. Henderson Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons J. Neurosci. Res. 74 2003 577 588 (Pubitemid 37352080)
38. M.L. Rathinam, L.T. Watts, A.A. Stark, L. Mahimainathan, J. Stewart, S. Schenker, and G.I. Henderson Astrocyte control of fetal cortical neuron glutathione homeostasis: up-regulation by ethanol J. Neurochem. 96 2006 1289 1300
39. J.K. Ryu, S.U. Kim, and J.G. McLarnon Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease Exp. Neurol. 187 2004 150 159 (Pubitemid 38470020)
40. T. Sairanen, R. Szepesi, M.L. Karjalainen-Lindsberg, J. Saksi, A. Paetau, and P.J. Lindsberg Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in Ischemic human stroke Acta Neuropathol. 118 2009 541 552
41. K. Sas, H. Robotka, E. Rozsa, M. Agoston, G. Szenasi, G. Gigler, M. Marosi, Z. Kis, T. Farkas, L. Vecsei, and J. Toldi Kynurenine diminishes the ischemia- induced histological and electrophysiological deficits in the rat hippocampus Neurobiol. Dis. 32 2008 302 308
42. T. Serafini Finding a partner in a crowd: neuronal diversity and synaptogenesis Cell 98 1999 133 136 (Pubitemid 29344901)
43. C.T. Sheline, M.M. Behrens, and D.W. Choi Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD+ and inhibition of glycolysis J. Neurosci. 20 2000 3139 3146 (Pubitemid 30263130)
44. R.J. Sokol, V. Delaney-Black, and B. Nordstrom Fetal alcohol spectrum disorder JAMA 290 2003 2996 2999 (Pubitemid 37505533)
45. E.R. Sowell, P.M. Thompson, S.N. Mattson, K.D. Tessner, T.L. Jernigan, E.P. Riley, and A.W. Toga Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol NeuroReport 12 2001 515 523 (Pubitemid 32173958)
46. E.R. Sowell, P.M. Thompson, S.N. Mattson, K.D. Tessne, T.L. Jernigan, E.P. Riley, and A.W. Toga Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure Cereb. Cortex 12 2002 856 865 (Pubitemid 34803885)
47. E.R. Sowell, P.M. Thompson, B.S. Peterson, S.N. Mattson, S.E. Welcome, A.L. Henkenius, E.P. Riley, T.L. Jernigan, and A.W. Toga Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure NeuroImage 17 2002 1807 1819 (Pubitemid 36062771)
48. A.Y. Sun, M. Ingelman-Sundberg, E. Neve, H. Matsumoto, Y. Nishitani, Y. Minowa, Y. Fukui, S.M. Bailey, V.B. Patel, C.C. Cunningham, T. Zima, L. Fialova, L. Mikulikova, P. Popov, I.J.M. Malbohan, K. Nespor, and G.Y. Sun Ethanol and oxidative stress Alcohol Clin. Exp. Res. 25 2001 237S 243S
49. T. Tenkova, C. Young, K. Dikranian, J. Labruyere, and J.W. Olney Ethanol-induced apoptosis in the developing visual system during synaptogenesis Invest. Ophthalmol. Vis. Sci. 44 2003 2809 2817 (Pubitemid 36759739)
50. M. Tsacopoulos, and P.J. Magistretti Metabolic coupling between glia and neurons J. Neurosci. 16 1996 877 885 (Pubitemid 26140843)
51. S.D. Varma, and K.R. Hegde Lens thiol depletion by peroxynitrite. Protective effect of pyruvate Mol. Cell Biochem. 298 2007 199 204 (Pubitemid 46605298)
52. A.G. Vlassenko, M.M. Rundle, M.E. Raichle, and M.A. Mintun Regulation of blood flow in activated human brain by cytosolic NADH/NAD ratio Proc. Natl. Acad. Sci. U.S.A. 103 2006 1964 1969 (Pubitemid 43228801)
53. X. Wang, E. Perez, R. Liu, L.J. Yan, R.T. Mallet, and S.H. Yang Pyruvate protects mitochondria from oxidative stress in human neuroblastoma SK-N-SH cells Brain Res. 1132 1 2007 1 9 (Pubitemid 46096455)
54. D.F. Wozniak, R.E. Hartman, M.P. Boyle, S.K. Vogt, A.R. Brooks, T. Tenkova, C. Young, J.W. Olney, and L.J. Muglia Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults Neurobiol. Dis. 17 2004 403 414 (Pubitemid 39574874)
55. C. Young, B.J. Klocke, T. Tenkova, J. Choi, J. Labruyere, Y.Q. Qin, D.M. Holtzman, K.A. Roth, and J.W. Olney Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain Cell Death Differ. 10 2003 1148 1155 (Pubitemid 37258580)
56. C. Young, K.A. Roth, B.J. Klocke, T. West, D.M. Holtzman, J. Labruyere, Y.Q. Qin, K. Dikranian, and J.W. Olney Role of caspase-3 in ethanol-induced developmental neurodegeneration Neurobiol. Dis. 20 2005 608 614 (Pubitemid 41476286)
57. J. Zeng, G.Y. Yang, W. Ying, M. Kelly, K. Hira, T.L. James, R.A. Swanson, and L. Litt Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebro cortical slices J. Cereb. Blood Flow Metab. 27 2007 304 315 (Pubitemid 46148457)