KIR/HLA: Genetic clues for a role of NK cells in the control of HIV

Advances in Experimental Medicine and Biology

Volumn 780, Issue , 2011, Pages 27-36

  Fadda, Lena ^a   Alter, Galit ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD56 ANTIGEN; HLA ANTIGEN; HLA B ANTIGEN; HLA B57 ANTIGEN; HLA C ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ANTIVIRAL ACTIVITY; CELL CLONE; CELL EXPANSION; CELL SPECIFICITY; CELL SURFACE; CONFERENCE PAPER; DISEASE COURSE; EFFECTOR CELL; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; INNATE IMMUNITY; LYMPHOCYTE SUBPOPULATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; DISEASE PROGRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV; HIV INFECTIONS; HLA ANTIGENS; HUMANS; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, KIR; SIGNAL TRANSDUCTION;

EID: 80053613746     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-5632-3_3     Document Type: Conference Paper

References (59)

1. Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22:633-640 (Pubitemid 33043908)
2. Moretta A, Bottino C, Mingari MC, Biassoni R, Moretta L (2002) What is a natural killer cell?. Nat Immunol 3:6-8 (Pubitemid 34065607)
3. Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225-274. doi:10.1146/annurev. immunol.23.021704.115526 (Pubitemid 40563170)
4. Cerwenka A, Lanier LL (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol 1:41-49 (Pubitemid 33741974)
5. Cooper MA, Fehniger TA, Fuchs A, Colonna M, Caligiuri MA (2004) NK cell and DC interactions. Trends Immunol 25:47-52 (Pubitemid 38032807)
6. Gerosa F et al (2002) Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med 195:327-333 (Pubitemid 34461490)
7. Gerosa F et al (2005) The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functions. J Immunol 174:727-734 (Pubitemid 40094266)
8. Chan A et al (2007) CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol 179:89-94. doi:179/1/89 [pii] (Pubitemid 46986521)
9. Romagnani C et al (2007) CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J Immunol 178:4947-1955. doi:178/8/4947 [pii]
10. Mavilio D et al (2005) Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci USA 102:2886-2891 (Pubitemid 40299886)
11. Alter G et al (2005) Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 106(10):3366-3369 (Pubitemid 41609166)
12. Ljunggren HG, Karre K (1990) In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 11:237-244 (Pubitemid 20198988)
13. Karre K, Ljunggren HG, Piontek G, Kiessling R (1986) Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319:675-678. doi:10.1038/319675a0 (Pubitemid 16119452)
14. Moretta A et al (1993) P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med 178:597-604 (Pubitemid 23218208)
15. Cerwenka A, Lanier LL (2001) Ligands for natural killer cell receptors: redundancy or specificity. Immunol Rev 181:158-169 (Pubitemid 32703404)
16. Kim S et al (2005) Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436:713. doi:nature03847 [pii] 10.1038/nature03847 (Pubitemid 41117274)
17. Anfossi N et al (2006) Human NK cell education by inhibitory receptors for MHC class I. Immunity 25:331-342. doi:S1074-7613(06)00348-7 [pii] 10.1016/j.immuni.2006.06.013 (Pubitemid 44224147)
18. Yu J et al (2007) Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. J Immunol 179:5977-5989. doi:179/9/5977 [pii]
19. Brodin P, Lakshmikanth T, Johansson S, Karre K, Hoglund P (2009) The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. Blood 113:2434-2441. doi:blood-2008-05-156836 [pii] 10.1182/blood-2008-05- 156836
20. Kim S et al (2008) HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc Natl Acad Sci USA 105:3053-3058 (Pubitemid 351723666)
21. Yawata M et al (2008) MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood 112:23692380. doi:blood-2008-03-143727 [pii] 10.1182/blood-2008-03-143727
22. Pessino A et al (1998) Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 188:953-960 (Pubitemid 28433421)
23. Lanier LL (2008) Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol 9:495-502. doi:ni1581[pii] 10.1038/ni1581 (Pubitemid 351560518)
24. Freud AG, Caligiuri MA (2006) Human natural killer cell development. Immunol Rev 214:56-72. doi:IMR451 [pii] 10.1111/j.1600-065X.2006.00451.x (Pubitemid 44707902)
25. Cao W et al (2008) Four novel ULBP splice variants are ligands for human NKG2D. Int Immunol 20:981-991. doi:dxn057 [pii] 10.1093/intimm/dxn057
26. Jinushi M et al (2003) Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid. Int J Cancer 104:354-361. doi:10.1002/ijc.10966 (Pubitemid 36249818)
27. Ward JP, Bonaparte MI, Barker E (2004) HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts. AIDS 18:1769-1779 (Pubitemid 39179628)
28. Cerboni C et al (2007) Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. J Gen Virol 88:242-250. doi:88/1/242 [pii] 10.1099/vir.0.82125-0 (Pubitemid 46085135)
29. Groh V, Wu J, Yee C, Spies T (2002) Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419:734-738. doi:10.1038/nature01112, nature01112 [pii] (Pubitemid 35177960)
30. Alter G et al (2010) IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection. J Clin Invest 120:1905-1913. doi:40913 [pii] 10.1172/JCI40913
31. Bashirova AA, Martin MP, McVicar DW, Carrington M (2006) The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu Rev Genomics Hum Genet 7:277-300 (Pubitemid 44627931)
32. Lanier LL (1998) NK cell receptors. Annu Rev Immunol 16:359-393 (Pubitemid 28183369)
33. Carrington M, Norman P (2003) The KIR gene cluster. NCBI, Bethesda
34. Anderson SK (2006) Transcriptional regulation of NK cell receptors. Curr Top Microbiol Immunol 298:59-75 (Pubitemid 41491723)
35. Stewart CA et al (2005) Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. Proc Natl Acad Sci USA 102:13224-13229. doi:0503594102 [pii] 10.1073/pnas.0503594102 (Pubitemid 41325005)
36. Boyington JC, Motyka SA, Schuck P, Brooks AG, Sun PD (2000) Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature 405:537-543 (Pubitemid 30367719)
37. Fan QR, Long EO, Wiley DC (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol 2:452-460. doi:10.1038/87766, 87766 [pii] (Pubitemid 33706144)
38. Malnati MS et al (1995) Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science 267:1016-1018
39. Correa I, Raulet DH (1995) Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity 2:61-71
40. Peruzzi M, Parker KC, Long EO, Malnati MS (1996) Peptide sequence requirements for the recognition of HLA-B 2705 by specific natural killer cells. J Immunol 157:3350-3356 (Pubitemid 126449146)
41. Rajagopalan S, Long EO (1997) The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. J Exp Med 185:1523-1528 (Pubitemid 27187611)
42. Zappacosta F, Borrego F, Brooks AG, Parker KC, Coligan JE (1997) Peptides isolated from HLA-Cw 0304 confer different degrees of protection from natural killer cell-mediated lysis. Proc Natl Acad Sci USA 94:6313-6318 (Pubitemid 27270681)
43. Fadda L et al (2010) Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci USA 107:10160-10165. doi:0913745107 [pii] 10.1073/pnas.0913745107
44. Fellay J et al (2007) A whole-genome association study of major determinants for host control of HIV-1. Science 317:944-947. doi:1143767 [pii] 10.1126/science.1143767 (Pubitemid 47301321)
45. Thomas R et al (2009) HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet 41:1290-1294. doi:ng.486 [pii] 10.1038/ng.486
46. Vitale M, Sivori S, Pende D, Moretta L, Moretta A (1995) Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells. Proc Natl Acad Sci USA 92:3536-3540
47. Carrington M, O'Brien SJ (2003) The influence of HLA genotype on AIDS. Annu Rev Med 54:535-551 (Pubitemid 37386411)
48. Flores-Villanueva PO et al (2001) Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc Natl Acad Sci USA 98:5140-5145 (Pubitemid 32397096)
49. Martin MP et al (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31:429-434 (Pubitemid 35154456)
50. Alter G et al (2007) Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med 204:3027-3036. doi:jem.20070695 [pii] 10.1084/jem.20070695 (Pubitemid 350179568)
51. Carrington M, Martin MP, van Bergen J (2008) KIR-HLA intercourse in HIV disease. Trends Microbiol 16(12):620-627. Epub 2008 Oct 29 PMID: 18976921
52. Martin MP et al (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet 39:733-740. doi:ng2035 [pii] 10.1038/ng2035 (Pubitemid 46848586)
53. De Maria A et al (2003) The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44). Eur J Immunol 33:2410-2418 (Pubitemid 37138973)
54. Mela CM et al (2005) Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy. AIDS 19:1761-1769 (Pubitemid 41546594)
55. Mavilio D et al (2003) Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci USA 100:15011-15016 (Pubitemid 37518008)
56. Long BR et al (2008) Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol 82:4785-4792. doi:JVI.02449-07 [pii] 10.1128/JVI.02449-07 (Pubitemid 351657040)
57. Alter G et al (2009) HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection. J Virol 83:6798-6805. doi: JVI.00256-09 [pii] 10.1128/JVI.00256-09
58. Boulet S et al (2010) HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells. J Immunol 184:2057-2064. doi:jimmunol.0902621 [pii] 10.4049/jimmunol.0902621
59. Yokoyama WM, Kim S (2006) Licensing of natural killer cells by self-major histocompatibility complex class I. Immunol Rev 214:143-154 (Pubitemid 44707908)