Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1239-1247

  Lee, Chun Yao ^a   Lee, Meng Larn ^a   Shih, Chien Cheng ^a   Liou, Horng Huei ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Antiepileptic drug; Carisbamate; Dentate gyrus; Epilepsy; Glutamate

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMPA RECEPTOR; CALCIUM CHANNEL; CARISBAMATE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TETRODOTOXIN; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC TRANSMISSION; GLUTAMATE TRANSMISSION; GRANULE CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; METABOLIC INHIBITION; NERVE CELL EXCITABILITY; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; WHOLE CELL;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; ANTICONVULSANTS; BIOPHYSICS; CALCIUM CHANNEL BLOCKERS; CARBAMATES; DENTATE GYRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; GLUTAMIC ACID; MALE; NEURONS; OMEGA-CONOTOXIN GVIA; PATCH-CLAMP TECHNIQUES; PICROTOXIN; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 80053611412     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.07.022     Document Type: Article

References (42)

1. T. Abrahamsson, B. Gustafasson, and E. Hanse Synaptic fatigue at the naïve perforant path-dentate granule cell synapse in the rat J. Physiol. 569.3 2005 737 750 (Pubitemid 41830219)
2. V. André, C. Dubé, J. Franois, C. Leroy, M.A. Rigoulot, C. Roch, I.J. Namer, and A. Nehlig Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model Epilepsia 48 Suppl. 5 2007 41 47 (Pubitemid 47512201)
3. M. Bialer, S.I. Johannessen, H.J. Kupferberg, R.H. Levy, E. Perucca, and T. Tomson Progress report on new antiepileptic drugs: a summary of the Eight Eilat Conference (EILAT VIII) Epilepsy Res. 73 2007 1 52 (Pubitemid 46091734)
4. P. Calabresi, D. Centonze, G.A. Marfia, A. Pisani, and G. Bernardi An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons Br. J. Pharmacol. 126 1999 689 696 (Pubitemid 29087848)
5. S. Chien, M. Bialer, B. Solanki, T. Verhaeghe, D.R. Doose, G. Novak, and C. Yao Pharmacokinetic interaction study between the new antiepileptic and CNS drug RWJ-333369 and carbamazepine in healthy adults Epilepsia 47 2006 1830 1840 (Pubitemid 44733929)
6. S. Chien, C. Yao, A. Mertens, T. Verhaeghe, B. Solanki, D.R. Doose, G. Novak, and M. Bialer An interaction study between the new antiepileptic and CNS drug carisbamate (RWJ-333369) and lamotrigine and valproic acid Epilepsia 48 2007 1328 1338 (Pubitemid 47063066)
7. A.M. Craig, and H. Boudin Molecular heterogeneity of central synapses: afferent and target regulation Nat. Neurosci. 4 2001 569 578 (Pubitemid 32507370)
8. M.O. Cunningham, A. Dhillon, S.J. Wood, and R.S. Jones Reciprocal modulation of glutamate and GABA release may underlie the anticonvulsant effect of phenytoin Neuroscience 95 2000 343 351
9. M.O. Cunningham, G.L. Woodhall, and S.G. Jones Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro Neuropharmacology 45 2003 907 917 (Pubitemid 37297916)
10. M.O. Cunningham, G.L. Woodhall, S.E. Thompson, D.J. Dooley, and R.S. Jones Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro Eur. J. Neurosci. 20 2004 1566 1576 (Pubitemid 39294695)
11. L.S. Deshpande, N. Nagarkatti, S. Sombati, and R.J. Delorenzo The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons Epilepsy Res. 79 2008 158 165
12. L.S. Deshpande, N. Nagarkatti, J.M. Ziobro, S. Sombati, and R.J. Delorenzo Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons Epilepsia 49 2008 1795 1802
13. M.J. During, and D.D. Spencer Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain Lancet 341 1993 1607 1610 (Pubitemid 23175242)
14. E. Faught, G.L. Holmes, W.E. Rosenfeld, G. Novak, W. Neto, A. Greenspan, J. Schmitt, E. Yuen, S. Reines, and M. Haas Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures Neurology 71 2008 1586 1593
15. J. Franois, A. Boehrer, and A. Nehlig Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS Epilepsia 49 2008 393 399 (Pubitemid 351294523)
16. J. Franois, K. Germe, A. Ferrandon, E. Koning, and A. Nehlig Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy Neuropharmacology 61 2011 313 328
17. S. Gabriel, M. Njunting, J.K. Pomper, M. Merschhemke, E.R. Sanabria, A. Eilers, A. Kivi, M. Zeller, H.J. Meencke, E.A. Cavalheiro, U. Heinemann, and T.N. Lehmann Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis J. Neurosci. 24 2003 10416 10430 (Pubitemid 39552627)
18. H.L. Grabenstatter, and F.E. Dudek A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy Epilepsia 49 2008 1787 1794
19. + channel inactivation to pair-pulse synaptic depression in cultured hippocampal neurons J. Neurophysiol. 87 2001 925 936 (Pubitemid 34670855)
20. C. Hennesberger, S. Kirischuk, and R. Grantyn Brain-derived neurotrophic factor modulates GABAergic synaptic transmission by enhancing presynaptic glutamate acid decarboxylase 65 levels, promoting asynchronous release and reducing the number of activated postsynaptic receptors Neuroscience 135 2005 749 763 (Pubitemid 41407739)
21. N.W. Kleckner, J.C. Glazewski, C.C. Chen, and T.D. Moscrip Subtype-selective antagonism of N-methyl-d-aspartate receptors by felbamate: insights into the mechanism of action J. Pharmacol. Exp. Ther. 289 1999 886 894 (Pubitemid 29191246)
22. C. Ladera, M. del Carmen Godino, M. José Cabañero, M. Torres, M. Watanabe, R. Luján, and J. Sánchez-Prieto Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex J. Neurochem. 107 2008 1506 1517
23. J.M. Langosch, X.Y. Zhou, A. Frick, H. Grunze, and J. Walden Effect of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices Epilepsia 41 2000 1102 1106
24. M.J. Leach, C.M. Marden, and A.A. Miller Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action Epilepsia 27 1986 490 497 (Pubitemid 16026042)
25. C.Y. Lee, W.M. Fu, C.C. Chen, M.J. Su, and H.H. Liou Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus Epilepsia 49 2008 888 897
26. C.Y. Lee, C.C. Chen, and H.H. Liou Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus Br. J. Pharmacol. 158 2009 1753 1762
27. Y. Liu, G.J. Yohrling, Y. Wang, T.L. Hutchinson, D.E. Brenneman, C.M. Flores, and B. Zhao Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons Epilepsy Res. 83 2009 66 72
28. R.N. Mamidi, G. Mannens, P. Annaert, J. Hendrickx, I. Goris, M. Bockx, C.G. Janssen, M. Kao, M.F. Kelley, and W. Meuldermans Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs Drug Metab. Dispos. 35 2007 566 575
29. G.S. Mannens, J. Hendrickx, C.G. Janssen, S. Chien, B. Van Hoof, T. Verhaeghe, M. Kao, M.F. Kelley, I. Goris, M. Bockx, B. Verreet, M. Bialer, and W. Meuldermans The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans Drug Metab. Dispos. 35 2007 554 565 (Pubitemid 46513257)
30. B.L. McNaughton, and C.A. Barnes Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat J. Comp. Neurol. 175 1997 439 454
31. J.V. Nadler The recurrent mossy fiber pathway of the epileptic brain Neurochem. Res. 28 2003 1649 1658 (Pubitemid 37296207)
32. A. Nehlig, M.-A. Rigoulot, and A. Boehrer A new drug, RWJ 333369 displays potent antiepileptic properties in genetic models of absence and audiogenic epilepsy Epilepsia 46 2005 106 109
33. G.P. Novak, M. Kelley, P. Zannikos, and B. Klein Carisbamate (RWJ-333369) Neurotherapeutics 4 2007 106 109 (Pubitemid 46107332)
34. D.J. Perkel, and R.A. Nicoll Evidence for all-or-none regulation of neurotransmitter release: implications for long-term potentiation J. Physiol. 471 1993 481 500 (Pubitemid 23345591)
35. A. Peretz, A. Sheinin, C. Yue, N. Degani-Katzav, G. Gibor, R. Nachman, A. Gopin, E. Tam, D. Shabat, Y. Yaari, and B. Attali Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release J. Neurophysiol. 97 2007 283 295 (Pubitemid 46143357)
36. M.A. Rogawski Diverse mechanisms of antiepileptic drugs in the development pipeline Epilepsy Res. 69 2006 273 294 (Pubitemid 44209049)
37. 2+ and glutamate release J. Neurochem. 53 1989 1693 1699 (Pubitemid 19283636)
38. + channel-dependent glutamate and GABA release in rat CNS J. Neurochem. 113 2010 1611 1620
39. B.J. Whalley, G.J. Stephens, and A. Constanti Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ-333369) on rat piriform cortical neurones in vitro Br. J. Pharmacol. 156 2009 994 1008
40. L.G. Wu, and P. Saggau Presynaptic inhibition of elicited neurotransmitter release Trends Neurosci. 20 1997 204 212 (Pubitemid 27158049)
41. S.P. Wu, J.J. Tsai, and P.W. Gean Frequency-dependent inhibition of neuronal activity by topiramate in rat hippocampal slice Br. J. Pharmacol. 125 1998 826 832
42. R. Zucker Short-term synaptic plasticity Annu. Rev. Neurosci. 12 1989 13 31 (Pubitemid 19085445)