15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA

Clinical and Experimental Allergy

Volumn 39, Issue 6, 2009, Pages 908-917

  Kim, Y K ^a   Jeon, S G ^a   Moon, H G ^a   Kim, Y S ^a   Choi, J P ^a   Shin, T S ^a   Hong, S W ^a   Tae, Y M ^a   Kim, S H ^b   Zhu, Z ^c   Gho, Y S ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Hanyang University College of Medicine   (South Korea)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

15 Lipoxygenase; Double stranded RNA; Th1 inflammation; Virus associated asthma

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ALLERGEN; ARACHIDONATE 15 LIPOXYGENASE; CD4 ANTIGEN; CD8 ANTIGEN; DOUBLE STRANDED RNA; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12P40; LEUKOTRIENE B4 RECEPTOR ANTAGONIST;

ALLERGIC ASTHMA; ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY CELL; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TH1 CELL; TH2 CELL;

ACETATES; ALLERGENS; ALUM COMPOUNDS; ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; DISEASE MODELS, ANIMAL; FATTY ALCOHOLS; FLUORENES; GLYCOLS; HYPERSENSITIVITY; INFLAMMATION; LEUKOTRIENE ANTAGONISTS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; POLY I-C; QUINOLINES; RECEPTORS, LEUKOTRIENE; RECEPTORS, LEUKOTRIENE B4; RNA, DOUBLE-STRANDED; TH1 CELLS; TH2 CELLS;

EID: 66149121447     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03211.x     Document Type: Article

References (43)

1. Stevenson EC, Turner G, Heaney LG et al. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy 1997 27 : 1027 35.
2. Martinez FD. Development of wheezing disorders and asthma in preschool children. Pediatrics 2002 109 (Suppl. 2) : 362 7.
3. Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 2007 62 : 211 8.
4. Yang YL, Reis LF, Pavlovic J et al. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. Embo J 1995 14 : 6095 106.
5. Guillot L, Le Goffic R, Bloch S et al. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 2005 280 : 5571 80.
6. Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy - the first sign of childhood asthma? J Allergy Clin Immunol 2003 111 : 66 71. (Pubitemid 36143293)
7. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3. Nature 2001 413 : 732 8.
8. Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD. Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3. J Allergy Clin Immunol 2004 114 : 174 82.
9. Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 441 : 101 5.
10. Jeon SG, Oh SY, Park HK et al. Th2 and Th1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. J Allergy Clin Immunol 2007 120 : 803 12.
11. Adamjee J, Suh YJ, Park HS et al. Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. J Pathol 2006 209 : 392 9.
12. Lotzer K, Jahn S, Kramer C et al. 5-lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells. Prostaglandins Other Lipid Mediat 2007 84 : 108 15.
13. Rorke S, Jennison S, Jeffs JA, Sampson AP, Arshad H, Holgate ST. Role of cysteinyl leukotrienes in adenosine 5′-monophosphate induced bronchoconstriction in asthma. Thorax 2002 57 : 323 7.
14. Kawano T, Matsuse H, Kondo Y et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. J Allergy Clin Immunol 2003 112 : 369 74.
15. Henderson WR Jr., Tang LO, Chu SJ et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002 165 : 108 16.
16. Wittwer J, Hersberger M. The two faces of the 15-lipoxygenase in atherosclerosis. Prostaglandins, Leukotr, Essent Fatty Acids 2007 77 : 67 77. (Pubitemid 47539103)
17. Harats D, Shaish A, George J et al. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice. Arterioscler, Thromb, Vasc Biol 2000 20 : 2100 5.
18. Ihara A, Wada K, Yoneda M, Fujisawa N, Takahashi H, Nakajima A. Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. J Pharmacol Sci 2007 103 : 24 32. (Pubitemid 46175592)
19. Sendobry SM, Cornicelli JA, Welch J et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 1997 120 : 1199 206.
20. Corne J, Chupp G, Lee CG et al. IL-13 stimulates vascular endothelial cell growth factor and protects against hyperoxic acute lung injury. J Clin Invest 2000 106 : 783 91.
21. Park Y, Chang YS, Lee SW et al. The enhanced effect of a hexameric deoxyriboguanosine run conjugation to CpG oligodeoxynucleotides on protection against allergic asthma. J Allergy Clin Immunol 2001 108 : 570 6.
22. Kim YK, Oh SY, Jeon SG et al. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 2007 178 : 5375 82.
23. Nayak A. A review of montelukast in the treatment of asthma and allergic rhinitis. Expert Opin Pharmacother 2004 5 : 679 86.
24. Kim ND, Chou RC, Seung E, Tager AM, Luster AD. A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med 2006 203 : 829 35.
25. Chu HW, Balzar S, Westcott JY et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy 2002 32 : 1558 65.
26. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999 353 : 2213 4.
27. Wenzel SE, Schwartz LB, Langmack EL et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999 160 : 1001 8.
28. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002 57 : 643 8.
29. Message SD, Johnston SL. The immunology of virus infection in asthma. Eur Respir J 2001 18 : 1013 25.
30. Kuhn H, Thiele BJ. The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. FEBS Lett 1999 449 : 7 11. (Pubitemid 29182660)
31. Shim YM, Zhu Z, Zheng T et al. Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling. J Immunol 2006 177 : 1918 24.
32. Turner CR, Breslow R, Conklyn MJ et al. In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma. J Clin Invest 1996 97 : 381 7.
33. Cyrus T, Pratico D, Zhao L et al. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 2001 103 : 2277 82.
34. George J, Afek A, Shaish A et al. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circulation 2001 104 : 1646 50.
35. Zhao L, Cuff CA, Moss E et al. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem 2002 277 : 35350 6.
36. Simon TC, Makheja AN, Bailey JM. Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe Heritable Hyperlipidemic and cholesterol-fed rabbits. Atherosclerosis 1989 75 : 31 8.
37. Bonnans C, Chanez P, Chavis C. Lipoxins in asthma: potential therapeutic mediators on bronchial inflammation? Allergy 2004 59 : 1027 41.
38. Levy BD, De Sanctis GT, Devchand PR et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 2002 8 : 1018 23.
39. Bonnans C, Levy BD. Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Am J Respir Cell Mol Biol 2007 36 : 201 5.
40. Lee CG, Homer RJ, Zhu Z et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001 194 : 809 21.
41. Lee CG, Cho SJ, Kang MJ et al. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 2004 200 : 377 89.
42. Kim YS, Xu ZG, Reddy MA et al. Novel interactions between TGF-[beta]1 actions and the 12/15-lipoxygenase pathway in mesangial cells. J Am Soc Nephrol 2005 16 : 352 62.
43. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003 3 : 23 35. (Pubitemid 37328697)