Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Alessandri, Ana L ^a   Duffin, Rodger ^a   Leitch, Andrew E ^a   Lucas, Christopher D ^a   Sheldrake, Tara A ^a   Dorward, David A ^a   Hirani, Nik ^a   Pinho, Vanessa ^b   de Sousa, Lirlândia Pires ^b   Teixeira, Mauro M ^b   Lyons, John F ^c   Haslett, Christopher ^a   Rossi, Adriano G ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AT 7519; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CYCLIN DEPENDENT KINASE INHIBITOR; UNCLASSIFIED DRUG; 4 (2,6 DICHLOROBENZOYLAMINO) 1H PYRAZOLE 3 CARBOXYLIC ACID PIPERIDIN 4 YLAMIDE; 4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID PIPERIDIN-4-YLAMIDE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ADULT; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL INFILTRATION; CLEARANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESPONSE; ENZYME INHIBITION; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PLEURISY; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; HYPERSENSITIVITY; IMMUNOLOGY; LEUKOCYTE; METABOLISM;

MURINAE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERSENSITIVITY; LEUKOCYTES; MICE; MICE, INBRED BALB C; PIPERIDINES; PYRAZOLES;

EID: 80053603444     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025683     Document Type: Article

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