Levels of interleukin-21 in patients with untreated chronic periodontitis

Journal of Periodontology

Volumn 82, Issue 10, 2011, Pages 1483-1489

  Dutzan, Nicolás ^a   Rivas, Catalina ^a   García Sesnich, Jocelyn ^a   Henríquez, Leslie ^a   Rivera, Oriana ^a   Dezerega, Andrea ^a   Hernández, Marcela ^a   Silva, Nora ^a   Aguillón, Juan Carlos ^a   Puente, Javier ^a   Vernal, Rolando ^a   Gamonal, Jorge ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Cytokines; Interleukin 21; Pathogenesis; Periodontal disease

Indexed keywords

INTERLEUKIN 21; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CHEMISTRY; CHI SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GINGIVA; GINGIVITIS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; NONPARAMETRIC TEST;

ADULT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GINGIVA; GINGIVAL CREVICULAR FLUID; HUMANS; INTERLEUKINS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 80053598874     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.100449     Document Type: Article

References (35)

1. Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Periodontol 2005;32(Suppl. 6):108-129. (Pubitemid 41391060)
2. Grossi SG, Zambon JJ, Ho AW, et al. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 1994;65:260-267.
3. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response. Crit Rev Oral Biol Med 2002;13:17-34. (Pubitemid 34792758)
4. Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontol 1996;1:821-878.
5. Brandt K, Singh PB, Bulfone-Paus S, Rückert R. Interleukin-21: A new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev 2007; 18:223-232. (Pubitemid 46891291)
6. Johnson RB, Wood N, Serio FG. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J Periodontol 2004;75:37-43. (Pubitemid 38312768)
7. Nurieva, Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007;448:480-483. (Pubitemid 47123514)
8. Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T(H)- 17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007;8:967-974. (Pubitemid 47300011)
9. Deenick EK, Tangye SG. Autoimmunity: IL-21: A new player in Th17-cell differentiation. Immunol Cell Biol 2007;85:503-505. (Pubitemid 47530594)
10. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
11. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25: 229-235.
12. Ramfjord SP, Nissle RR. The modified Widman flap. J Periodontol 1974;45:601-607.
13. Brown LJ, Löe H. Prevalence, extent, severity and progression of periodontal disease. Periodontol 2000 1993;2:57-71.
14. Genco RJ, Grossi SG, Ho A, Nishimura F, Murayama Y. A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol 2005;76(Suppl. 11):2075-2084. (Pubitemid 41748956)
15. Scannapieco FA, Genco RJ. Association of periodontal infections with atherosclerotic and pulmonary diseases. J Periodontal Res 1999;34:340-345.
16. Gamonal J, Mendoza C, Espinoza I, et al. Clinical attachment loss in Chilean adult population: First Chilean National Dental Examination Survey. J Periodontol 2010;81:1403-1410.
17. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: Cellular and molecular mechanisms. J Periodontal Res 1993;28:478-486.
18. Seymour GJ. Importance of the host response in the periodontium. J Clin Periodontol 1991;18:421-426.
19. Langrish CL, Chen Y, Blumenschein WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 2005;201:233-240. (Pubitemid 40189432)
20. Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007;25:221-242. (Pubitemid 46697908)
21. Glimcher LH, Murphy KM. Lineage commitment in the immune system: The T helper lymphocyte grows up. Genes Dev 2000;14:1693-1711. (Pubitemid 30602989)
22. Aggarwal S, Gurney AL. IL-17: Prototype member of an emerging cytokine family. J Leukoc Biol 2002;71: 1-8. (Pubitemid 34062767)
23. Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol 2004;114:1265-1273, quiz 1274. (Pubitemid 39585195)
24. Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 2003;14:155-174. (Pubitemid 36389528)
25. Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27. (Pubitemid 44116697)
26. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-562. (Pubitemid 38680433)
27. Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-1886. (Pubitemid 38032120)
28. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24: 179-189. (Pubitemid 43214587)
29. Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007;448:484-487. (Pubitemid 47123515)
30. Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol 2005;17:638-642. (Pubitemid 41506909)
31. Volpe E, Servant N, Zollinger R, et al. A critical function for transforming growth factor-b, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008;9:650-657. (Pubitemid 351712635)
32. Manel N, Unutmaz D, Littman DR. The differentiation of human Th17 cells requires transforming growth factor-b and induction of the nuclear receptor RORgt. Nat Immunol 2008;9:641-649. (Pubitemid 351714729)
33. Cheng X, Yu X, Ding YJ, et al. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin Immunol 2008;127:89-97.
34. Fina D, Fantini MC, Pallone F, Monteleone G. Role of interleukin-21 in inflammation and allergy. Inflamm Allergy Drug Targets 2007;6:63-68. (Pubitemid 46488300)
35. Ferrari-Lacraz S, Chicheportiche R, Schneiter G, Molnarfi N, Villard J, Dayer JM. IL-21 promotes survival and maintains a naive phenotype in human CD4+ T lymphocytes. Int Immunol 2008;20:1009-1018.