Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: A multicenter trial

Pediatrics

Volumn 114, Issue 6, 2004, Pages 1649-1657

  Watterberg, Kristi L ^a   Gerdes, Jeffrey S ^b   Cole, Cynthia H ^c   Aucott, Susan W ^d   Thilo, Elizabeth H ^e   Mammel, Mark C ^f,g   Couser, Robert J ^f   Garland, Jeffery S ^h   Rozycki, Henry J ⁱ   Leach, Corinne L ^j   Backstrom, Conra ^a   Shaffer, Michele L ^k  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b PENNSYLVANIA HOSPITAL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Children's Hospital Colorado   (United States)

^f CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

^g UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^h MEDICAL COLLEGE OF WISCONSIN   (United States)

ⁱ VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY AT BUFFALO   (United States)

^k PENN STATE COLLEGE OF MEDICINE   (United States)

more..

Author keywords

Adrenal insufficiency; Adrenocorticotropic hormone; BPD; Bronchopulmonary dysplasia; Extremely low birth weight infants; Hydrocortisone

Indexed keywords

ANTIHYPERTENSIVE AGENT; HYDROCORTISONE; HYDROCORTISONE SODIUM SUCCINATE; INDOMETACIN; INSULIN; SOLU CORTEF PLAIN;

ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ARTICLE; ARTIFICIAL VENTILATION; BIRTH WEIGHT; BRAIN HEMORRHAGE; CHORIOAMNIONITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIGESTIVE SYSTEM PERFORATION; DOUBLE BLIND PROCEDURE; DRUG FATALITY; ENCEPHALOMALACIA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEAD CIRCUMFERENCE; HORMONE RESPONSE; HOSPITAL INFECTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERGLYCEMIA; HYPERKALEMIA; HYPERNATREMIA; HYPERTENSION; HYPONATREMIA; LOW DRUG DOSE; LUNG DYSPLASIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; NECROTIZING ENTEROCOLITIS; NEWBORN; OXYGEN SATURATION; OXYGEN THERAPY; PATENT DUCTUS ARTERIOSUS; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RETROLENTAL FIBROPLASIA; SEPSIS; SURVIVAL RATE; CHEMICALLY INDUCED DISORDER; DISEASE FREE SURVIVAL; DRUG EFFECT; INTESTINE PERFORATION; MULTICENTER STUDY; PREGNANCY; PREMATURITY; STOMACH; TREATMENT FAILURE; VERY LOW BIRTH WEIGHT;

ADRENAL INSUFFICIENCY; BRONCHOPULMONARY DYSPLASIA; CHORIOAMNIONITIS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYDROCORTISONE; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INFANT, VERY LOW BIRTH WEIGHT; INTESTINAL PERFORATION; MALE; PREGNANCY; STOMACH; TREATMENT FAILURE;

EID: 16644367782     PISSN: 00314005     EISSN: 00314005     Source Type: Journal    
DOI: 10.1542/peds.2004-1159     Document Type: Article

References (46)

1. Lamberts SWJ, Bruining HA, de Jong FH. Corticosteroid therapy in severe illness. N Engl J Med. 1997;337:1285-1292
2. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med. 2003;348:727-734
3. Joosten KFM, De Kleijn ED, Westerterp M, et al. Endocrine and metabolic responses in children with meningococcal sepsis: striking differences between survivors and nonsurvivors. J Clin Endocrinol Metab. 2000;85:3746-3753
4. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:862-871
5. Mesiano S, Jaffe RB. Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev. 1997;18:378-403
6. Huysman MWA, Hokken-Koelega ACS, DeRidder MAJ, Sauer PJJ. Adrenal function in sick very preterm infants. Pediatr Res. 2000;48:629-633
7. Scott SM, Watterberg KL. Effect of gestational age, postnatal age, and illness on plasma cortisol concentrations in premature infants. Pediatr Res. 1995;37:112-116
8. Ng PC, Lee CH, Kam CWK, et al. Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birth weight infants. Arch Dis Child Fetal Neonatal Ed. 2004;89:F119-F126
9. Scott SM, Cimino DF. Evidence for developmental hypopituitarism in ill preterm infants. J Perinatol. 2004;24:429-434
10. Chrousos GP. The hypothalamic-pituitary-adrenal axis and immunemediated inflammation. N Engl J Med. 1995;332:1351-1362
11. Goujon E, Parnet P, Laye S, Combe C, Dantzer R. Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Res Mol Brain Res. 1996;36:53-62
12. Watterberg KL, Scott SM. Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia. Pediatrics. 1995;95:120-125
13. Watterberg KL, Scott SM, Backstrom C, Gifford KL, Cook KL. Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus. Pediatrics. 2000;105:320-324
14. Korte C, Styne D, Merritt TA, Mayes D, Wertz A, Helbock HJ. Adrenocortical function in the very low birth weight infant: improved testing sensitivity and association with neonatal outcome. J Pediatr. 1996;128:257-263
15. Watterberg KL, Demers LM, Scott SM, Murphy S. Chorioamnionitis and early lung inflammation in babies who develop bronchopulmonary dysplasia. Pediatrics. 1996;97:210-215
16. Yoon BH, Romero R, Kim KS, et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1999;181:773-779
17. Yoon BH, Romero R, Jun JK, et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-α, interleukin-1β, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1997;177:825-830
18. Viscardi RM, Muhumuza CK, Rodriguez A, et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr Res. 2004;55:1009-1017
19. Ozdemir A, Brown MA, Morgan WJ. Markers and mediators of inflammation in neonatal lung disease. Pediatr Pulmonol. 1997;23:292-306
20. Watterberg KL, Gerdes JS, Gifford KL, Lin H-M. Prophylaxis against early adrenal insufficiency to prevent chronic lung disease in premature infants. Pediatrics. 1999;104:1258-1263
21. The Vermont Oxford Network Steroid Study Group. Early postnatal dexamethasone therapy for the prevention of chronic lung disease. Pediatrics. 2001;108:741-748
22. Stark AR, Carlo WA, Tyson JE, et al. Adverse effects of early dexamethasone in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med. 2001;344:95-101
23. Tyson JE, Wright LL, Oh W, et al. Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med. 1999;340:1962-1968
24. Watterberg KL, Cook K, Gifford KL. Pharmacokinetics of hydrocortisone in extremely low birth weight infants in the first week of life [abstract]. Pediatr Res. 1996;39:251A
25. Redline RW, Wilson-Costello D, Hack M. Placental and other perinatal risk factors for chronic lung disease in very low birth weight infants. Pediatr Res. 2002;52:713-719
26. McCullagh P, Nelder JA. Binary data. In: Generalized Linear Models. 2nd ed. London, England: Chapman and Hall; 1989:124-128
27. Cox DR. Regression models and life-tables (with discussion). J R Stat Soc [Ser B]. 1972;34:187-220
28. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13-22
29. Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics. 1982;38:963-974
30. Cockburn F, Cooke RWI, Gamsu HR, et al. The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. The International Neonatal Network. Lancet. 1993;342:193-198
31. Watterberg KL, Scott SM, Naeye RL. Chorioamnionitis, cortisol, and acute lung disease in very low birth weight infants. Pediatrics. 1997; 99(2). Available at: www.pediatrics.org/cgi/content/full/99/2/e6
32. Watterberg KL, the PROPHET study group. A cosyntropin dose of 0.1μg/kg is inadequate to test adrenal function in extremely low birth weight infants [abstract]. Pediatr Res. 2004;55:154A
33. Van Marter LJ, Dammann O, Allred EN, et al. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002;140:171-176
34. Shimoya K, Taniguchi T, Matsuzaki N, et al. Chorioamnionitis decreased incidence of respiratory distress syndrome by elevating fetal interleukin-6 serum concentration. Hum Reprod. 2000;15:2234-2240
35. Jobe AH, Ikegami M. Antenatal infection/inflammation and postnatal lung maturation and injury. Respir Res. 2001;2:27-32
36. Al Saedi S, Dean H, Dent W, Cronin C. Reference ranges for serum cortisol and 17-hydroxyprogesterone levels in preterm infants. J Pediatr. 1995;126:985-997
37. Banks BA, Stouffer N Cnaan A, et al. Association of plasma cortisol and chronic lung disease in preterm infants. Pediatrics. 2001;107:494-498
38. Ng PC, Lee CH, Lam CWK, et al. Early pituitary-adrenal response and respiratory outcomes in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2004;89:F127-F130
39. Horbar JD, Carpenter JH, eds. Vermont Oxford Network 2002 Database Summary. Burlington, VT: Vermont Oxford Network; 2003
40. Shorter NA, Liu JY, Mooney DP, Harmon BJ. Indomethacin-associated bowel perforations: a study of possible risk factors. J Pediatr Surg. 1999;34:442-444
41. Ruh J, Schmidt E, Vogel F, Klar E. Indomethacin-induced disturbances in villous microcirculation in the rat ileum. Microvasc Res. 1999;58:137-142
42. Rainsford KD, Stetsko PI, Sirko SP, Debski S. Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indomethacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. J Pharm Pharmacol. 2003;55:661-668
43. Tanaka A, Hase S, Miyazawa T, Ohno R, Takeuchi K. Role of cyclooxygenase (COX)-1 and COX2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events. J Pharmacol Exp Ther. 2002;303:1248-1254
44. Filaretova L, Tanaka A, Miyazawa T, Kato S, Takeuchi K. Mechanisms by which endogenous glucocorticoid protects against indomethacininduced gastric injury in rats. Am J Physiol Gastrointest Liver Physiol. 2002;283:G1082-G1089
45. Gordon PV, Price WA, Stiles AD, Rutledge JC. Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants. Pediatr Dev Pathol. 2001;4:532-537
46. Gordon PV, Paxton JB, Herman AC, Carlisle EM, Fox NS. IGF-1 accelerates ileal epithelial cell migration in culture and newborn mice and may be a mediator of steroid-induced maturation. Pediatr Res. 2004;55:34-41