Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1222-1228

  Winocur, Gordon ^a,b,c   Binns, Malcolm A ^a,b   Tannock, Ian ^b,d  

^a ROTMAN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TRENT UNIVERSITY   (Canada)

^d PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

5 fluorouracil; Animal model; Cognitive impairment; Donepezil; Methotrexate

Indexed keywords

DONEPEZIL; FLUOROURACIL; METHOTREXATE; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATIVE MEMORY; CANCER COMBINATION CHEMOTHERAPY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; EXECUTIVE FUNCTION; EXPERIMENTAL TEST; FEMALE; LEARNING; MORNING DOSAGE; MOUSE; NON MATCHING TO SAMPLE TEST; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE; TREATMENT DURATION;

ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COGNITION DISORDERS; CUES; DISEASE MODELS, ANIMAL; FEMALE; FLUOROURACIL; INDANS; MAZE LEARNING; MEMORY; METHOTREXATE; MICE; MICE, INBRED BALB C; NOOTROPIC AGENTS; PIPERIDINES; SPACE PERCEPTION; TIME FACTORS;

EID: 80053593594     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.07.013     Document Type: Article

References (45)

1. Y. Abe, A. Aoyagi, T. Hara, K. Abe, R. Yamazak, and Y. Kumagae Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease J. Pharmacol. Sci. 93 2003 95 105 (Pubitemid 37254273)
2. J.P. Aggleton, P.R. Hunt, and J.N.P. Rawlins The effects of hippocampal lesions upon spatial and non-spatial tests of working memory Behav. Brain Res. 19 1986 133 146 (Pubitemid 16127880)
3. T.A. Ahles, and A.J. Saykin Candidate mechanisms for chemotherapy-induced cognitive changes Nat. Rev. Cancer 7 2007 192 201
4. C. Anderson-Hanley, M.L. Sherman, R. Riggs, V.B. Agocha, and B.E. Compas Neuropsychological effects of treatments for adults with cancer: a meta-analysis and review of the literature J. Int. Neuropsychol. Soc. 9 2003 967 982 (Pubitemid 37428441)
5. C.W. Cotman, and N.C. Berchtold Exercise: a behavioral intervention to enhance brain health and plasticity Trends Neurosci. 25 2002 295 301 (Pubitemid 34667010)
6. J. Dietrich, M. Monje, J. Wefel, and C. Meyers Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy Oncologist 13 2008 1285 1295
7. M. ElBeltagy, S. Mustafa, J. Umka, L. Lyons, A. Salman, and G.T. Chur-yoe Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil Behav. Brain Res. 208 2010 112 117
8. M.G. Falleti, A. Sanfilippo, P. Maruff, L. Weih, and K.A. Phillips The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: a meta-analysis of the current literature Brain Cogn. 59 2005 60 70 (Pubitemid 41405841)
9. J.E. Fardell, J. Vardy, W. Logge, and I. Johnston Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents Pharmacol. Biochem. Behav. 97 2010 333 339
10. R.J. Ferguson, T.A. Ahles, A.J. Saykin, B.C. McDonald, C.T. Furstenberg, and B.F. Cole Cognitive-behavioral management of chemotherapy-related cognitive change Psychooncology 16 2007 772 777 (Pubitemid 47249179)
11. J.J. Foley, R.B. Raffa, and E.A. Walker Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory Psychopharmacology (Berl.) 199 2008 527 538
12. L. Fratiglioni, S. Paillard-Borg, and B. Winblad An active and socially integrated lifestyle in late life might protect against dementia Lancet 3 2004 343 353 (Pubitemid 38648855)
13. C.M. Hernandez, D.A. Gearhart, V. Parikh, E.J. Hohnadel, L.W. Davis, and M.L. Middlemore Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats J. Pharmacol. Exp. Ther. 316 2006 679 694 (Pubitemid 43130995)
14. M. Inagaki, E. Yoshikawa, Y. Matsuoka, Y. Sugawara, T. Nakano, and T. Akechi Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy Cancer 109 2007 146 156 (Pubitemid 46120202)
15. C.E. Jansen, C. Miaskowski, M. Dodd, G. Dowling, and J. Kramer A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function Cancer 104 2005 2222 2233 (Pubitemid 41579970)
16. I. Kendall, H.A. Slotten, X. Codony, J. Burgueno, P.J. Pauwels, and J.M. Vela E-6801, a 5-HT(6) receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat Psychopharmacology (Berl.) 213 2011 413 430
17. R.E. Kirk Experimental Design: Procedures for the Behavioral Sciences 1968 Wadsworth New York
18. G.W. Konat, M. Kraszpulski, I. James, H.T. Zhang, and J. Abraham Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats Metab. Brain Dis. 23 2008 325 333
19. S. Kotani, T. Yamauchi, T. Teramoto, and H. Ogura Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis Neuroscience 142 2006 505 514 (Pubitemid 44415335)
20. A.F. Kramer, L. Bherer, S.J. Colcombe, W. Dong, and W.T. Greenough Environmental influences on cognitive and brain plasticity during aging J. Gerontol. A. Biol. Sci. Med. Sci. 59 2004 M940 M957
21. B. Levine, I.H. Robertson, L. Clare, G. Carter, J. Hong, and B.A. Wilson Rehabilitation of executive functioning: an experimental-clinical validation of goal management training J. Int. Neuropsychol. Soc. 6 2000 299 312 (Pubitemid 30303642)
22. L. Lyons, M. Elbeltagy, J. Umka, R. Markwick, C. Startin, and G. Bennett Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy Psychopharmacology (Berl.) 215 2011 105 115
23. R.A. McDonald, A.-M. Ergis, and G. Winocur Functional dissociation of brain regions in learning and memory: evidence for multiple systems J.K. Foster, M. Jelicic, Memory: Systems, Process or Function 1999 Oxford University Press New York 66 103
24. H.G. Mar Fan, M. Clemons, W. Xu, I. Chemerynsky, H. Breunis, and S. Braganza A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer Support Care Cancer 16 2008 577 583
25. J. Meunier, J. Ieni, and T. Maurice The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor Br. J. Pharmacol. 149 2006 998 1012 (Pubitemid 44950803)
26. R.G. Morris, P. Garrud, J.N. Rawlins, and J. O'Keefe Place navigation impaired in rats with hippocampal lesions Nature 297 1982 681 683 (Pubitemid 12096189)
27. M. Moscovitch, and G. Winocur The frontal cortex and working with memory D.T. Stuss, R.T. Knight, Principles of Frontal Lobe Function 2002 Oxford University Press New York 188 209
28. T. Murai, S. Okuda, T. Tanaka, and H. Ohta Characteristics of object location memory in mice: behavioral and pharmacological studies Physiol. Behav. 90 2007 116 124 (Pubitemid 44918011)
29. J.A. O'Shaughnessy Effects of epoetin alfa on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant chemotherapy Clin. Breast Cancer Suppl. 3 2002 S116 S120
30. L. Pusztai, T.R. Mendoza, J.M. Reuben, M.M. Martinez, J.S. Willey, and J. Lara Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy Cytokine 25 2004 94 102 (Pubitemid 38096266)
31. R. Rajamani, A. Muthuvel, M. Senthilvelan, and R. Sheeladevi Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve Toxicol. Lett. 165 2006 265 273
32. B. Schneiderman Hippocampal volumes smaller in chemotherapy patients Lancet Oncol. 5 2004 202 (Pubitemid 38391208)
33. R. Seigers, and J.E. Fardell Neurobiological basis of chemotherapy-induced cognitive impairment: a review of rodent research Neurosci. Biobehav. Rev. 35 2011 729 741
34. R. Seigers, S.B. Schagen, W. Beerling, W. Boogerd, O. van Tellingen, and F.S. van Dam Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat Behav. Brain Res. 186 2008 168 175 (Pubitemid 350122748)
35. E.G. Shaw, R. Rosdhal, R.B. D'Agostino Jr., J. Lovato, M.J. Naughton, and M.E. Robbins Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life J. Clin. Oncol. 24 2006 1415 1420 (Pubitemid 46622007)
36. D.T. Stuss, I.H. Robertson, F.I.M. Craik, B. Levine, M.P. Alexander, and S. Black Cognitive rehabilitation in the elderly: a randomized trial to evaluate a new protocol J. Int. Neuropsychol. Soc. 13 2007 120 123
37. J. Vardy, S. Rourke, and I.F. Tannock Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research J. Clin. Oncol. 25 2007 2455 2463 (Pubitemid 46999217)
38. J. Vardy, and I. Tannock Cognitive function after chemotherapy in adults with solid tumours Crit. Rev. Oncol. Hematol. 63 2007 183 202 (Pubitemid 47126866)
39. P.J. Whitehouse, D.L. Price, R.G. Struble, A.W. Clark, J.T. Coyle, and M.R. Delon Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain Science 215 1982 1237 1239 (Pubitemid 12106486)
40. G. Winocur A comparison of normal old rats and young adult rats with lesions to the hippocampus or prefrontal cortex on a test of matching-to-sample Neuropsychologia 30 1992 769 781
41. G. Winocur, J. Vardy, M.A. Binns, L. Kerr, and I. Tannock The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice Pharmacol. Biochem. Behav. 85 2006 66 75 (Pubitemid 44802737)
42. G. Winocur, J.M. Wojtowicz, M. Sekeres, J.S. Snyder, and S. Wang Inhibition of neurogenesis interferes with hippocampus-dependent memory function Hippocampus 16 2006 296 304
43. R.T. Woods, and L. Clare Cognitive-based therapies and mild cognitive impairment H. Tuokko, D.F. Hultsch, Mild Cognitive Impairment: International Perspectives 2006 Taylor and Francis New York 245 264
44. A.J. Xu, Z. Chen, K. Yanai, Y.W. Huang, and E.Q. Wei Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8 -yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats Neurosci. Lett. 331 2002 33 36 (Pubitemid 35279376)
45. L. Zhang, R.C. Plotkin, G. Wang, M.E. Sandel, and S. Lee Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury Arch. Phys. Med. Rehabil. 85 2004 1050 1055 (Pubitemid 38962359)