Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents

Pharmacology Biochemistry and Behavior

Volumn 97, Issue 2, 2010, Pages 333-339

  Fardell, Joanna E ^a,b   Vardy, Janette ^a,b   Logge, Warren ^a   Johnston, Ian ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CANCER INSTITUTE NSW   (Australia)

Author keywords

Chemotherapy; Cognitive impairment; Executive function; Memory; Methotrexate; Rat

Indexed keywords

METHOTREXATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISCRIMINATION LEARNING; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; SINGLE DRUG DOSE; SPATIAL MEMORY; TASK PERFORMANCE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BODY WEIGHT; COGNITION DISORDERS; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; MEMORY; METHOTREXATE; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY);

ANIMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 77957773399     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.08.019     Document Type: Article

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