Learning not to fear: A neural systems approach

Understanding Trauma: Integrating Biological, Clinical, and Cultural Perspectives

Volumn , Issue , 2007, Pages 60-77

  Quirk, Gregory J ^a   Milad, Mohammed R ^b   Santini, Edwin ^a   Lebron, Kelimer ^b  

^a PONCE SCHOOL OF MEDICINE   (Puerto Rico)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053591315     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511500008.006     Document Type: Chapter

References (84)

1. Akins, C. K., Domjan, M., & Gutierrez, G. (1994). Topography of sexually conditioned behavior in male Japanese quail (Coturnix japonica) depends on the CS-US interval. Journal of Experimental Psychology: Animal Behavior Processes, 20, 199-209.
2. Ayres, J. J. B., Berger-Gross, P., Kohler, E. A., Mahoney, W. J., & Stone, S. (1979). Some orderly nonmonotonicities in the trial-by-trial acquisition of conditioned suppression: Inhibition with reinforcement? Animal Learning & Behavior, 7, 174-180.
3. Barlow, D. H. (2002). Anxiety and its disorders: The nature and treatment of anxiety and panic (2nd ed.). New York: Guilford Press.
4. Bolles, R. C.,&Fanselow, M. S. (1980).Aperceptual-defensive-recuperative model of fear and pain. Behavioral & Brain Sciences, 3, 291-323.
5. Bouton, M. E. (1984). Differential control by context in the inflation and reinstatement paradigms. Journal of Experimental Psychology: Animal Behavior Processes, 10, 56-74.
6. Bouton,M.E. (1988). Context and ambiguity in the extinction of emotional learning: Implications for exposure therapy. Behaviour Research and Therapy, 26, 137-149.
7. Bouton, M. E. (1993). Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychological Bulletin, 114, 80-99.
8. Bouton, M. E. (2002). Context, ambiguity, and unlearning: Sources of relapse after behavioral extinction. Biological Psychiatry, 52, 976-986.
9. Bouton, M. E. (2004). Context and behavioral processes in extinction. Learning & Memory, 11, 485-494.
10. Bouton, M. E. (2005). Behavior systems and the contextual control of anxiety, fear and panic. In L. F. Barrett, P. Niedenthal, & P. Winkelman (Eds.), Emotion: Conscious and unconscious (pp. 205-227). New York: Guilford.
11. Bouton, M. E., & Bolles, R. C. (1979a). Contextual control of the extinction of conditioned fear. Learning and Motivation, 10, 445-466.
12. Bouton, M. E., & Bolles, R. C. (1979b). Role of conditioned contextual stimuli in reinstatement of extinguished fear. Journal of Experimental Psychology: Animal Behavior Processes, 5, 368-378.
13. Bouton, M. E., & Brooks, D. C. (1993). Time and context effects on performance in a Pavlovian discrimination reversal. Journal of Experimental Psychology: Animal Behavior Processes, 19, 165-179.
14. Bouton, M. E., Kenney, F. A., & Rosengard, C. (1990). State-dependent fear extinction with two benzodiazepine tranquilizers. Behavioral Neuroscience, 104, 44-55.
15. Bouton, M. E., & King, D. A. (1983). Contextual control of the extinction of conditioned fear: Tests for the associative value of the context. Journal of Experimental Psychology: Animal Behavior Processes, 9, 248-265.
16. Bouton, M. E.,&King, D. A. (1986). Effect of context on performance to conditioned stimuli with mixed histories of reinforcement and nonreinforcement. Journal of Experimental Psychology: Animal Behavior Processes, 12, 4-15.
17. Bouton, M. E., Mineka, S., & Barlow, D. H. (2001). A modern learning theory perspective on the etiology of panic disorder. Psychological Review, 108, 4-32.
18. Bouton, M. E., & Nelson, J. B. (1994). Context-specificity of target versus feature inhibition in a feature-negative discrimination. Journal of Experimental Psychology: Animal Behavior Processes, 20, 51-65.
19. Bouton, M. E., & Peck, C. A. (1989). Context effects on conditioning, extinction, and reinstatement in an appetitive conditioning preparation. Animal Learning & Behavior, 17, 188-198.
20. Bouton, M. E., & Peck, C. A. (1992). Recovery in cross-motivational transfer (counterconditioning). Animal Learning & Behavior, 20, 313-321.
21. Bouton, M. E., & Ricker, S. T. (1994). Renewal of extinguished responding in a second context. Animal Learning & Behavior, 22, 317-324.
22. Bouton, M. E., & Swartzentruber, D. (1991). Sources of relapse after extinction in Pavlovian and instrumental learning. Clinical Psychology Review, 11, 123-140.
23. Bremner, J. D., Licinio, J., Darnell, A., Krystal, J. H., Owens, M., Southwick, S. M., et al. (1997). Elevated CSF corticotrophin-releasing factor concentrations in posttraumatic stress disorder. American Journal of Psychiatry, 154, 624-629.
24. Bremner, J. D., Southwick, S. M., Johnson, D. R., Yehuda, R.,&Charney, D. S. (1993). Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. American Journal of Psychiatry, 150, 235-239.
25. Breslau, N., & Davis, G. C. (1992). Posttraumatic stress disorder in an urban population of young adults: Risk factors for chronicity. American Journal of Psychiatry, 149, 671-675.
26. Brooks, D. C. (2000). Recent and remote extinction cues reduce spontaneous recovery. Quarterly Journal of Experimental Psychology, 53B, 25-58.
27. Brooks, D. C.,&Bouton, M. E. (1993).A retrieval cue for extinction attenuates spontaneous recovery. Journal of Experimental Psychology: Animal Behavior Processes, 19, 77-89.
28. Brooks, D. C., & Bouton, M. E. (1994). A retrieval cue for extinction attenuates response recovery (renewal) caused by a return to the conditioning context. Journal of Experimental Psychology: Animal Behavior Processes, 20, 366-379.
29. Brooks, D. C., Hale, B., Nelson, J. B., & Bouton, M. E. (1995). Reinstatement after counter conditioning. Animal Learning & Behavior, 23, 383-390.
30. Brown, J. S., Kalish, H. I., & Farber, I. E. (1951). Conditioned fear as revealed by magnitude of startle response to an auditory stimulus. Journal of Experimental Psychology, 41, 317-327.
31. Collins, B. N., & Brandon, T. H. (2002). Effects of extinction context and retrieval cues on alcohol cue reactivity among nonalcoholic drinkers. Journal of Consulting and Clinical Psychology, 70, 390-397.
32. Corcoran, K. A., & Maren, S. (2004). Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction. Learning & Memory, 11, 598-603.
33. Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993). Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis. Journal of Comparative Neurology, 332, 1-20.
34. Cunningham, C. L. (1979). Alcohol as a cue for extinction: State dependency produced by conditioned inhibition. Animal Learning & Behavior, 7, 45-52.
35. Davis, M., & Lee, Y. (1998). Fear and anxiety: Possible roles of the amygdala and bed nucleus of the stria terminalis. Cognition and Emotion, 12, 277-305.
36. Davis, M., & Shi, C. (1999). The extended amygdala: Are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety? Annals of the New York Academy of Sciences, 877, 281-291.
37. Davis, M.,Walker, D. L.,&Lee, Y. (1997). Roles for the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex. Annals of the New York Academy of Sciences, 821, 305-331.
38. Domjan, M. (1994). Formulation of a behavior system for sexual conditioning. Psychonomic Bulletin & Review, 1, 421-428.
39. Fanselow, M. S. (2000). Contextual fear, gestalt memories, and the hippocampus. Behavioural Brain Research, 110, 73-81.
40. Fanselow, M. S., & Lester, L. S. (1988). A functional behavioristic approach to aversively motivated behavior: Predatory imminence as a determinant of the topography of defensive behavior. In R. C. Bolles & M. D. Beecher (Eds.), Evolution and learning (pp. 185-212). Hillsdale, NJ: Lawrence Erlbaum Associates.
41. Francis, D. D., & Meaney, M. J. (1999). Maternal care and the development of stress response. Current Opinion in Neurobiology, 9, 128-134.
42. Frohardt, R. J., Guarraci, F. A., & Bouton, M. E. (2000). The effects of neurotoxic hippocampal lesions on two effects of context after fear extinction. Behavioral Neuroscience, 114, 227-240.
43. Hitchcock, J. M., & Davis, M. (1991). Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm. Behavioral Neuroscience, 105, 826-842.
44. Kaye, H.,&Mackintosh, N. J. (1990).Achange of context can enhance performance of an aversive but not of an appetitive conditioned response. Quarterly Journal of Experimental Psychology, 42B, 113-134.
45. Kim, J. J., & Fanselow, M. S. (1992). Modality specific retrograde amnesia of fear. Science, 256, 675-677.
46. Kinzie, J. D., Boehnlein, M. D., Riley, M. A.,&Sparr, L. (2002). The effects of September 11 on traumatized refugees: Reactivation of posttraumatic stress disorder. Journal of Nervous and Mental Disease, 190, 437-441.
47. LeDoux, J. E. (2000). Emotional circuits in the brain. Annual Reviews in Neuroscience, 23, 155-184.
48. Lee, Y., & Davis, M. (1997). Role of the hippocampus, the bed nucleus of the stria terminalis and the amygdala in the excitatory effect of corticotropin-releasing hormone on the acoustic startle reflex. Journal of Neuroscience, 1, 6434-6446.
49. Liu, D., Tannenbum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., et al. (1997). Maternal care, hippocampal glucocorticoid receptor gene expression and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659-1662.
50. McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., & Bannerman, D. M. (2004). Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behavioral Neuroscience, 118, 63-78.
51. Mineka, S., & Zinbarg, R. (1996). Conditioning and ethological models of anxiety disorders: Stress-in-dynamic-context anxiety models. In D. A. Hope (Ed.), Current theory and research in motivation: Vol. 43. Perspectives on anxiety, panic, and fear (pp. 135-210). Lincoln: University of Nebraska Press.
52. Mystkowski, J. L., Craske, M. G., & Echiverri, A. M. (2002). Treatment context and return of fear in spider phobia. Behavior Therapy, 33, 399-416.
53. Mystkowski, J. L., Craske, M. G., Echiverri, A. M., & Labus, J. S. (2006). Mental reinstatement of context and return of fear in spider-fearful participants. Behavior Therapy, 37, 49-60.
54. Nelson, J. B., & Bouton, M. E. (1997). The effects of a context switch following serial and simultaneous feature-negative discriminations. Learning and Motivation, 28, 56-84.
55. Orr, S. P., Metzger, L. J., Lasko, N. B., Macklin, M. L., Peri, T., & Pitman, R. K. (2000). De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. Journal of Abnormal Psychology, 109, 290-298.
56. Overmier, J. B., Payne, J., Brackbill, R. M., Linder, B., & Lawry, J. A. (1979). On the mechanism of the post-asymptotic CR decrement phenomenon. Acta Neurobiologiae Experimentalis, 39, 603-620.
57. Overton, D. A. (1985). Contextual stimulus effects of drugs and internal states. In P. D. Balsam & A. Tomie (Eds.), Context and learning (pp. 357-384). Hillsdale, NJ: Erlbaum.
58. Pavlov, I. P. (1927). Conditioned reflexes. London: Oxford University Press.
59. Peck, C. A., & Bouton, M. E. (1990). Context and performance in aversive-toappetitive and appetitive-to-aversive transfer. Learning and Motivation, 21, 1-31.
60. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
61. Pitman, R. K., Shalev, A. Y., & Orr, S. P. (2000). Posttraumatic stress disorder: Emotion, conditioning and memory. In M. S. Gazzanig (Ed.), The Cognitive Neurosciences (pp. 1133-1147). Cambridge, MA: MIT Press.
62. Rescorla, R. A., & Heth, C. (1975). Reinstatement of fear to an extinguished conditioned stimulus. Journal of Experimental Psychology: Animal Behavior Processes, 1, 88-96.
63. Rescorla, R. A.,&Solomon, R. L. (1967). Two-process learning theory: Relationships between Pavlovian conditioning and instrumental learning. Psychological Review, 74, 151-182.
64. Rosas, J. M., & Bouton, M. E. (1997). Renewal of a conditioned taste aversion upon return to the conditioning context after extinction in another one. Learning and Motivation, 28, 216-229.
65. Rosas, J. M., Vila, N. J., Lugo, M., & Lopez, L. (2001). Combined effect of context change and retention interval on interference in causality judgments. Journal of Experimental Psychology: Animal Behavior Processes, 27, 153-164.
66. Shalev, A. Y., & Ursano, R. (2003). Mapping the multidimensional picture of acute responses to traumatic stress. In R. Orner & V. Schnyder (Eds.), Reconstructing early intervention after trauma: Innovations in the care of survivors (pp. 118-129). New York: Oxford University Press.
67. Smith, S. M., & Vela, E. (2001). Environmental context-dependent memory: A review and meta-analysis. Psychonomic Bulletin & Review, 8, 203-220.
68. Solomon, A., Garb, R., Bleich, A., & Grupper, D. (1987). Reactivation of traumarelated posttraumatic stress disorder. American Journal of Psychiatry, 144, 51-55.
69. Sullivan, G. M., Apergis, J., Bush, D. E. A., Johnson, L. R., Hou, M., & LeDoux, J. E. (2004). Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not a specific cue-conditioned fear stimulus. Neuroscience, 128, 7-14.
70. Sun, N., Roberts, L., & Cassell, M. D. (1991). Rat central amygdaloid nucleus projections to the bed nucleus of the stria terminalis. Brain Research Bulletin, 27, 651-662.
71. Timberlake,W. (2001). Motivational modes in behavior systems. In R. R. Mowrer & S. B. Klein (Eds.), Handbook of contemporary learning theories (pp. 155-210). Mahwah, NJ: Erlbaum.
72. Toren, P., Wolmer, L., Weizman, R., Magal-Vardi, O., & Laor, N. (2002). Retraumatization of Israeli civilians during a reactivation of the GulfWar threat. Journal of Nervous and Mental Disease, 190, 43-45.
73. Treit, D., Pesold, C., & Rotzinger, S. (1993). Dissociating the anti-fear effects of septal and amygdaloid lesions using two pharmacologically validated models of rat anxiety. Behavioral Neuroscience, 107, 770-785.
74. VanDerCar, D. H., & Schneiderman, N. (1967). Interstimulus interval functions in different response systems during classical discrimination conditioning of rabbits. Psychonomic Science, 9, 9-10.
75. Vigorito, M., & Ayres, J. J. B. (1987). Effect of naloxone on conditioned suppression in rats. Behavioral Neuroscience, 101, 576-586.
76. Waddell, J., Falls, W. A., Bouton, M. E., & Lowe, H. B. (2006). Central antagonism of central corticotropin-releasing factor blocks reinstatement of extinguished fear. Manuscript in preparation.
77. Waddell, J., Morris, R.,&Bouton, M. E. (2006). Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: Reinstatement and aversive conditioning with long-duration conditional stimuli. Behavioral Neuroscience, 120, 324-336.
78. Wagner, A. R., & Brandon, S. E. (1989). Evolution of a structured connectionist model of Pavlovian conditioning (AESOP). In S. B. Klein & R. R. Mowrer (Eds.), Contemporary learning theories: Pavlovian conditioning and the states of traditional learning theory (pp. 149-189). Hillsdale, NJ: Erlbaum.
79. Wilson, A., Brooks, D. C., & Bouton, M. E. (1995). The role of the rat hippocampal system in several effects of context in extinction. Behavioral Neuroscience, 109, 828-836.
80. Wolpe, J. (1958). Psychotherapy by reciprocal inhibition. Stanford, CA: Stanford University Press.
81. Yehuda, R., Giller, E. L., Southwick, S. M., Lowy, M. T., & Mason, J. W. (1991). Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder. Biological Psychiatry, 30, 1031-1048.
82. Yehuda, R., Golier, J. A., Halligan, S. L., Meaney, M., & Bierer, L. M. (2004). The ACTH response to dexamethasone in PTSD. American Journal of Psychiatry, 161, 1397-1403.
83. Yehuda, R., Schmeidler, J.,Wainberg, M., Binder-Brynes, K.,&Duvdevani,T. (1998). Vulnerability to posttraumatic stress disorder in adult offspring of Holocaust survivors. American Journal of Psychiatry, 155, 1163-1171.
84. Yehuda, R., Southwick, S. M., Nussbaum, E. L., Giller, E. L., & Mason, J.W. (1991). Low urinary cortisol in PTSD. Journal of Nervous and Mental Disease, 178, 366-369.