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Volumn 1, Issue 2, 2010, Pages 109-116

Cell penetrating peptides can exert biological activity: A review

Author keywords

biological activity; cell penetrating peptides; gene expression; protein kinase; protein transduction domains; proteolytic activity

Indexed keywords


EID: 80053586988     PISSN: 18685021     EISSN: 1868503X     Source Type: Journal    
DOI: 10.1515/bmc.2010.016     Document Type: Review
Times cited : (11)

References (74)
  • 2
    • 33646383091 scopus 로고    scopus 로고
    • Distribution of immunoglobulin fab fragment conjugated with hiv-1 rev peptide following intravenous administration in rats
    • Kameyama S, Okada R, Kikuchi T, Omura T, Nakase I, Takeuchi T, Sugiura Y, Futaki S. Distribution of immunoglobulin Fab fragment conjugated with HIV-1 REV peptide following intravenous administration in rats. Mol Pharm 2006; 3: 174-80
    • (2006) Mol Pharm , vol.3 , pp. 174-180
    • Kameyama, S.1    Okada, R.2    Kikuchi, T.3    Omura, T.4    Nakase, I.5    Takeuchi, T.6    Sugiura, Y.7    Futaki, S.8
  • 3
    • 0033106072 scopus 로고    scopus 로고
    • High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates
    • Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem 1999; 10: 186-91
    • (1999) Bioconjug Chem , vol.10 , pp. 186-191
    • Josephson, L.1    Tung, C.H.2    Moore, A.3    Weissleder, R.4
  • 5
    • 67649408951 scopus 로고    scopus 로고
    • Sirna delivery using peptide transduction domains
    • Eguchi A, Dowdy SF. siRNA delivery using peptide transduction domains. Trends Pharmacol Sci 2009; 30: 341-5
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 341-345
    • Eguchi, A.1    Dowdy, S.F.2
  • 7
    • 77949741829 scopus 로고    scopus 로고
    • Intracellular transduction using cell-penetrating peptides
    • Sawant R, Torchilin V. Intracellular transduction using cell-penetrating peptides. Mol Biosyst 2010; 6: 628-40
    • (2010) Mol Biosyst , vol.6 , pp. 628-640
    • Sawant, R.1    Torchilin, V.2
  • 8
    • 5644276383 scopus 로고    scopus 로고
    • Delivery of bioactive molecules into the cell: The trojan horse approach
    • Dietz GP, Bahr M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci 2004; 27: 85-131
    • (2004) Mol Cell Neurosci , vol.27 , pp. 85-131
    • Dietz, G.P.1    Bahr, M.2
  • 9
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-Activator protein
    • Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-Activator protein. Cell 1988; 55: 1179-88
    • (1988) Cell , vol.55 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 10
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988; 55: 1189-93
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 11
    • 0030904245 scopus 로고    scopus 로고
    • A truncated hiv-1 tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • Vives E, Brodin P, Lebleu B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 1997; 272: 16010-7
    • (1997) J Biol Chem , vol.272 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 12
    • 0026784945 scopus 로고
    • Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide
    • Perez F, Joliot A, Bloch-Gallego E, Zahraoui A, Triller A, Prochiantz A. Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide. J Cell Sci 1992; 102: 717-22
    • (1992) J Cell Sci , vol.102 , pp. 717-722
    • Perez, F.1    Joliot, A.2    Bloch-Gallego, E.3    Zahraoui, A.4    Triller, A.5    Prochiantz, A.6
  • 13
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285: 1569-72
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 15
    • 74049160383 scopus 로고    scopus 로고
    • Revised role of glycosaminoglycans in tat protein transduction domain-mediated cellular transduction
    • Gump JM, June RK, Dowdy SF. Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction. J Biol Chem 2010; 285: 1500-7
    • (2010) J Biol Chem , vol.285 , pp. 1500-1507
    • Gump, J.M.1    June, R.K.2    Dowdy, S.F.3
  • 19
    • 0141907727 scopus 로고    scopus 로고
    • Cellular uptake wcorrection of utakex of the tat peptide: An endocytosis mechanism following ionic interactions
    • Vives E. Cellular uptake wcorrection of utakex of the Tat peptide: an endocytosis mechanism following ionic interactions. J Mol Recognit 2003; 16: 265-71
    • (2003) J Mol Recognit , vol.16 , pp. 265-271
    • Vives, E.1
  • 20
    • 0347895102 scopus 로고    scopus 로고
    • Synthetic smac/diablo peptides enhance the effects of chemotherapeutic agents by binding xiap and ciap1 in situ
    • Arnt CR, Chiorean MV, Heldebrant MP, Gores GJ, Kaufmann SH. Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. J Biol Chem 2002; 277: 44236-43
    • (2002) J Biol Chem , vol.277 , pp. 44236-44243
    • Arnt, C.R.1    Chiorean, M.V.2    Heldebrant, M.P.3    Gores, G.J.4    Kaufmann, S.H.5
  • 22
    • 70449698651 scopus 로고    scopus 로고
    • Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence pfvyli linked to the proapoptotic domain peptide pad
    • Watkins CL, Brennan P, Fegan C, Takayama K, Nakase I, Futaki S, Jones AT. Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. J Control Release 2009; 140: 237-44
    • (2009) J Control Release , vol.140 , pp. 237-244
    • Watkins, C.L.1    Brennan, P.2    Fegan, C.3    Takayama, K.4    Nakase, I.5    Futaki, S.6    Jones, A.T.7
  • 24
    • 0033565263 scopus 로고    scopus 로고
    • A p21(waf1/cip1)carboxyl-Terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells
    • Mutoh M, Lung FD, Long YQ, Roller PP, Sikorski RS, O'Connor PM. A p21(Waf1/Cip1)carboxyl-Terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells. Cancer Res 1999; 59: 3480-8
    • (1999) Cancer Res , vol.59 , pp. 3480-3488
    • Mutoh, M.1    Lung, F.D.2    Long, Y.Q.3    Roller, P.P.4    Sikorski, R.S.5    O'connor, P.M.6
  • 28
    • 70549109798 scopus 로고    scopus 로고
    • Isolation of novel cell-penetrating peptides from a random peptide library using in vitro virus and their modifications
    • Kamide K, Nakakubo H, Uno S, Fukamizu A. Isolation of novel cell-penetrating peptides from a random peptide library using in vitro virus and their modifications. Int J Mol Med 2010; 25: 41-51
    • (2010) Int J Mol Med , vol.25 , pp. 41-51
    • Kamide, K.1    Nakakubo, H.2    Uno, S.3    Fukamizu, A.4
  • 29
    • 33644861571 scopus 로고    scopus 로고
    • Mechanism of uptake of c105y, a novel cellpenetrating peptide
    • Rhee M, Davis P. Mechanism of uptake of C105Y, a novel cellpenetrating peptide. J Biol Chem 2006; 281: 1233-40
    • (2006) J Biol Chem , vol.281 , pp. 1233-1240
    • Rhee, M.1    Davis, P.2
  • 31
    • 70449686720 scopus 로고    scopus 로고
    • Design of a bioactive cell-penetrating peptide: When a transduction domain does more than transduce
    • Ward B, Seal BL, Brophy CM, Panitch A. Design of a bioactive cell-penetrating peptide: when a transduction domain does more than transduce. J Pept Sci 2009; 15: 668-74
    • (2009) J Pept Sci , vol.15 , pp. 668-674
    • Ward, B.1    Seal, B.L.2    Brophy, C.M.3    Panitch, A.4
  • 34
    • 0034126420 scopus 로고    scopus 로고
    • New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vectormediated strategy
    • Rousselle C, Clair P, Lefauconnier JM, Kaczorek M, Scherrmann JM, Temsamani J. New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vectormediated strategy. Mol Pharmacol 2000; 57: 679-86
    • (2000) Mol Pharmacol , vol.57 , pp. 679-686
    • Rousselle, C.1    Clair, P.2    Lefauconnier, J.M.3    Kaczorek, M.4    Scherrmann, J.M.5    Temsamani, J.6
  • 35
    • 0035204427 scopus 로고    scopus 로고
    • A peptide carrier for the delivery of biologically active proteins into mammalian cells
    • Morris MC, Depollier J, Mery J, Heitz F, Divita G. A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol 2001; 19: 1173-6
    • (2001) Nat Biotechnol , vol.19 , pp. 1173-1176
    • Morris, M.C.1    Depollier, J.2    Mery, J.3    Heitz, F.4    Divita, G.5
  • 36
    • 0035937124 scopus 로고    scopus 로고
    • Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
    • Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, Ueda K, Sugiura Y. Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 2001; 276: 5836-40
    • (2001) J Biol Chem , vol.276 , pp. 5836-5840
    • Futaki, S.1    Suzuki, T.2    Ohashi, W.3    Yagami, T.4    Tanaka, S.5    Ueda, K.6    Sugiura, Y.7
  • 38
    • 0028239908 scopus 로고
    • The third helix of the antennapedia homeodomain translocates through biological membranes
    • Derossi D, Joliot AH, Chassaing G, Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 1994; 269: 10444-50
    • (1994) J Biol Chem , vol.269 , pp. 10444-10450
    • Derossi, D.1    Joliot, A.H.2    Chassaing, G.3    Prochiantz, A.4
  • 40
    • 0035478616 scopus 로고    scopus 로고
    • Ve-cadherinderived cell-penetrating peptide, pvec, with carrier functions
    • Elmquist A, Lindgren M, Bartfai T, Langel U. VE-cadherinderived cell-penetrating peptide, pVEC, with carrier functions. Exp Cell Res 2001; 269: 237-44
    • (2001) Exp Cell Res , vol.269 , pp. 237-244
    • Elmquist, A.1    Lindgren, M.2    Bartfai, T.3    Langel, U.4
  • 41
    • 0039174260 scopus 로고    scopus 로고
    • Nuclear import of adenovirus dna in vitro involves the nuclear protein import pathway and hsc70
    • Saphire AC, Guan T, Schirmer EC, Nemerow GR, Gerace L. Nuclear import of adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70. J Biol Chem 2000; 275: 4298-304
    • (2000) J Biol Chem , vol.275 , pp. 4298-4304
    • Saphire, A.C.1    Guan, T.2    Schirmer, E.C.3    Nemerow, G.R.4    Gerace, L.5
  • 43
    • 0031471203 scopus 로고    scopus 로고
    • Intercellular trafficking and protein delivery by a herpesvirus structural protein
    • Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88: 223-33
    • (1997) Cell , vol.88 , pp. 223-233
    • Elliott, G.1    O'hare, P.2
  • 45
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor nf-kappa b by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 1995; 270: 14255-8
    • (1995) J Biol Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3    Torgerson, T.R.4    Hawiger, J.5
  • 46
  • 47
    • 0035863391 scopus 로고    scopus 로고
    • Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo
    • Ho A, Schwarze SR, Mermelstein SJ, Waksman G, Dowdy SF. Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo. Cancer Res 2001; 61: 474-7
    • (2001) Cancer Res , vol.61 , pp. 474-477
    • Ho, A.1    Schwarze, S.R.2    Mermelstein, S.J.3    Waksman, G.4    Dowdy, S.F.5
  • 48
    • 0011766331 scopus 로고
    • Conjugation of poly-l-lysine to albumin and horseradish peroxidase: A novel method of enhancing the cellular uptake of proteins
    • Shen WC, Ryser HJ. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Proc Natl Acad Sci USA 1978; 75: 1872-6
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 1872-1876
    • Shen, W.C.1    Ryser, H.J.2
  • 49
    • 17344388277 scopus 로고    scopus 로고
    • Permeation and pathways of human calcitonin (hct) across excised bovine nasal mucosa
    • Lang S, Rothen-Rutishauser B, Perriard JC, Schmidt MC, Merkle HP. Permeation and pathways of human calcitonin (hCT) across excised bovine nasal mucosa. Peptides 1998; 19: 599-607
    • (1998) Peptides , vol.19 , pp. 599-607
    • Lang, S.1    Rothen-Rutishauser, B.2    Perriard, J.C.3    Schmidt, M.C.4    Merkle, H.P.5
  • 51
    • 33646507726 scopus 로고    scopus 로고
    • Developing novel hct derived cell-penetrating peptides with improved metabolic stability
    • Rennert R, Wespe C, Beck-Sickinger AG, Neundorf I. Developing novel hCT derived cell-penetrating peptides with improved metabolic stability. Biochim Biophys Acta 2006; 1758: 347-54
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 347-354
    • Rennert, R.1    Wespe, C.2    Beck-Sickinger, A.G.3    Neundorf, I.4
  • 52
    • 0031590315 scopus 로고    scopus 로고
    • Extensive cellular uptake into endothelial cells of an amphipathic beta-sheet forming peptide
    • Oehlke J, Krause E, Wiesner B, Beyermann M, Bienert M. Extensive cellular uptake into endothelial cells of an amphipathic beta-sheet forming peptide. FEBS Lett 1997; 415: 196-9
    • (1997) FEBS Lett , vol.415 , pp. 196-199
    • Oehlke, J.1    Krause, E.2    Wiesner, B.3    Beyermann, M.4    Bienert, M.5
  • 53
    • 0033168280 scopus 로고    scopus 로고
    • A highly membrane-Active peptide in flock house virus: Implications for the mechanism of nodavirus infection
    • Bong DT, Steinem C, Janshoff A, Johnson JE, Reza Ghadiri M. A highly membrane-Active peptide in Flock House virus: implications for the mechanism of nodavirus infection. Chem Biol 1999; 6: 473-81
    • (1999) Chem Biol , vol.6 , pp. 473-481
    • Bong, D.T.1    Steinem, C.2    Janshoff, A.3    Johnson, J.E.4    Reza Ghadiri, M.5
  • 54
    • 0037016020 scopus 로고    scopus 로고
    • Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7
    • Sadler K, Eom KD, Yang JL, Dimitrova Y, Tam JP. Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7. Biochemistry 2002; 41: 14150-7
    • (2002) Biochemistry , vol.41 , pp. 14150-14157
    • Sadler, K.1    Eom, K.D.2    Yang, J.L.3    Dimitrova, Y.4    Tam, J.P.5
  • 56
    • 0030804766 scopus 로고    scopus 로고
    • A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
    • Morris MC, Vidal P, Chaloin L, Heitz F, Divita G. A new peptide vector for efficient delivery of oligonucleotides into mammalian cells. Nucleic Acids Res 1997; 25: 2730-6
    • (1997) Nucleic Acids Res , vol.25 , pp. 2730-2736
    • Morris, M.C.1    Vidal, P.2    Chaloin, L.3    Heitz, F.4    Divita, G.5
  • 57
    • 34548771163 scopus 로고    scopus 로고
    • A novel cell-penetrating peptide m918, for efficient delivery of proteins and peptide nucleic acids
    • El-Andaloussi S, Johansson HJ, Holm T, Langel U. A novel cell-penetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids. Mol Ther 2007; 15: 1820-6
    • (2007) Mol Ther , vol.15 , pp. 1820-1826
    • El-Andaloussi, S.1    Johansson, H.J.2    Holm, T.3    Langel, U.4
  • 58
    • 34548484580 scopus 로고    scopus 로고
    • Delivery of short interfering rna using endosomolytic cellpenetrating peptides
    • Lundberg P, El-Andaloussi S, Sutlu T, Johansson H, Langel U. Delivery of short interfering RNA using endosomolytic cellpenetrating peptides. FASEB J 2007; 21: 2664-71
    • (2007) FASEB J , vol.21 , pp. 2664-2671
    • Lundberg, P.1    El-Andaloussi, S.2    Sutlu, T.3    Johansson, H.4    Langel, U.5
  • 59
    • 25144520907 scopus 로고    scopus 로고
    • On the mechanisms of the internalization of s4(13)-pv cell-penetrating peptide
    • Mano M, Teodosio C, Paiva A, Simoes S, de Lima MCP. On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptide. Biochem J 2005; 390: 603-12
    • (2005) Biochem J , vol.390 , pp. 603-612
    • Mano, M.1    Teodosio, C.2    Paiva, A.3    Simoes, S.4    De Lima McP5
  • 60
    • 3142774800 scopus 로고    scopus 로고
    • Potential peptide carriers: Amphipathic proline-rich peptides derived from the n-Terminal domain of gamma-zein
    • Fernandez-Carneado J, Kogan MJ, Castel S, Giralt E. Potential peptide carriers: amphipathic proline-rich peptides derived from the N-Terminal domain of gamma-zein. Angew Chem Int Ed Engl 2004; 43: 1811-4
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 1811-1814
    • Fernandez-Carneado, J.1    Kogan, M.J.2    Castel, S.3    Giralt, E.4
  • 61
    • 58149099412 scopus 로고    scopus 로고
    • Comparison of cellular uptake using 22 cpps in 4 different cell lines
    • Mueller J, Kretzschmar I, Volkmer R, Boisguerin P. Comparison of cellular uptake using 22 CPPs in 4 different cell lines. Bioconjug Chem 2008; 19: 2363-74
    • (2008) Bioconjug Chem , vol.19 , pp. 2363-2374
    • Mueller, J.1    Kretzschmar, I.2    Volkmer, R.3    Boisguerin, P.4
  • 63
    • 0034129207 scopus 로고    scopus 로고
    • Arginine-based structures are specific inhibitors of cathepsin C Application of peptide combinatorial libraries
    • Horn M, Pavlik M, Doleckova L, Baudys M, Mares M. Arginine-based structures are specific inhibitors of cathepsin C. Application of peptide combinatorial libraries. Eur J Biochem 2000; 267: 3330-6
    • (2000) Eur J Biochem , vol.267 , pp. 3330-3336
    • Horn, M.1    Pavlik, M.2    Doleckova, L.3    Baudys, M.4    Mares, M.5
  • 64
    • 33845865278 scopus 로고    scopus 로고
    • Short polybasic peptide sequences are potent inhibitors of pc5/6 and pc7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
    • Fugere M, Appel J, Houghten RA, Lindberg I, Day R. Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences. Mol Pharmacol 2007; 71: 323-32
    • (2007) Mol Pharmacol , vol.71 , pp. 323-332
    • Fugere, M.1    Appel, J.2    Houghten, R.A.3    Lindberg, I.4    Day, R.5
  • 66
    • 71749110589 scopus 로고    scopus 로고
    • Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling
    • Kilk K, Mahlapuu R, Soomets U, Langel U. Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling. Toxicology 2009; 265: 87-95
    • (2009) Toxicology , vol.265 , pp. 87-95
    • Kilk, K.1    Mahlapuu, R.2    Soomets, U.3    Langel, U.4
  • 67
    • 70349431107 scopus 로고    scopus 로고
    • Interactions between octaarginine and u-937 human macrophages: Global gene expression profiling, superoxide anion content, and cytokine production
    • Kuo JH, Jan MS, Lin YL, Lin C. Interactions between octaarginine and U-937 human macrophages: global gene expression profiling, superoxide anion content, and cytokine production. J Control Release 2009; 139: 197-204
    • (2009) J Control Release , vol.139 , pp. 197-204
    • Kuo, J.H.1    Jan, M.S.2    Lin, Y.L.3    Lin, C.4
  • 72
    • 0030739229 scopus 로고    scopus 로고
    • Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (hsp25) kinase
    • Hayess K, Benndorf R. Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. Biochem Pharmacol 1997; 53: 1239-47
    • (1997) Biochem Pharmacol , vol.53 , pp. 1239-1247
    • Hayess, K.1    Benndorf, R.2


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