Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD

Journal of Controlled Release

Volumn 140, Issue 3, 2009, Pages 237-244

  Watkins, Catherine L ^a   Brennan, Paul ^b   Fegan, Christopher ^c   Takayama, Kentaro ^d   Nakase, Ikuhiko ^d   Futaki, Shiroh ^d   Jones, Arwyn T ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell penetrating peptides; Endocytosis; Octaarginine; Proapoptotic domain

Indexed keywords

APOPTOSIS; CELL LINES; CELL MORPHOLOGY; CELL SYSTEM; CELL VIABILITY; CELL-PENETRATING PEPTIDE; CELLULAR UPTAKE; CYTOTOXIC; HELA CELL; HUMAN CELLS; IN-VIVO; LEUKAEMIA CELLS; LOCALISATION; MACROMOLECULAR THERAPEUTICS; PLASMA MEMBRANES; RELATIVE SENSITIVITY; SMALL-MOLECULE DRUGS; SUB-CELLULAR;

AMINES; BIOLOGICAL MEMBRANES; CELL CULTURE; CELL DEATH; CELL MEMBRANES; FUNCTIONAL POLYMERS; HYDROPHOBICITY; PEPTIDES;

CYTOTOXICITY;

ARGININE DERIVATIVE; DRUG; LYSYLLEUCYLALANYLLYSYLLEUCYLALANYLLYSYLLYSYLLEUCYLALANYLLYSYLLEUCYLALANYLLYSINE; OCTAARGININE; PEPTIDE; PROPYLPHENYLALANYLVALYLTYROSYLLEUCYLISOLEUCINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CELL STRUCTURE; CELL TRANSPORT; CELL VIABILITY; CHEMOSENSITIVITY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

APOPTOSIS REGULATORY PROTEINS; CELL ADHESION; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CYTOSOL; FLOW CYTOMETRY; HELA CELLS; HUMANS; INDICATORS AND REAGENTS; LEUKEMIA; OLIGOPEPTIDES; PEPTIDES; TEMPERATURE;

EID: 70449698651     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.04.028     Document Type: Article

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