A scintigraphic investigation of the disintegration behaviour of capsules in fasting subjects: A comparison of hypromellose capsules containing carrageenan as a gelling agent and standard gelatin capsules

European Journal of Pharmaceutical Sciences

Volumn 30, Issue 3-4, 2007, Pages 251-255

  Tuleu, C ^a   Khela, M K ^b   Evans, D F ^b   Jones, B E ^c,d   Nagata, S ^e   Basit, A W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c Qualicaps Europe SA   (Spain)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e Qualicaps Co Ltd   (Japan)

Author keywords

Capsules; Carrageenan; Disintegration; Gamma camera; Gelatin; Hypromellose

Indexed keywords

CARRAGEENAN; GELATIN; HYDROXYPROPYLMETHYLCELLULOSE; INDIUM 111; LACTOSE; QUALI-V; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CAPSULE DISINTEGRATION; DRUG CAPSULE; ESOPHAGUS; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; ISOTOPE LABELING; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SCINTILLATION CAMERA; STOMACH; SWALLOWING; VOLUNTEER;

ADULT; CAPSULES; CARRAGEENAN; EXCIPIENTS; FASTING; GAMMA RAYS; GELATIN; GELS; HUMANS; MALE; METHYLCELLULOSE; SOLUBILITY;

EID: 33847103207     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.11.008     Document Type: Article

References (18)

1. Bailey Jr. R.T., Bonavina L., McChesney L., Spires K.J., Muilenburg M.I., McGill J.E., and DeMeester T.R. Factors influencing the transit of a gelatin capsule in the esophagus. Drug Intell. Clin. Pharm. 21 (1987) 282-285
2. Batchelor H. Bioadhesive dosage forms for esophageal drug delivery. Pharm Res. 22 (2005) 175-181
3. Brown J., Madit N., Cole E.T., Wilding I.R., and Cade D. The effect of cross-linking on the in vivo disintegration of hard gelatin capsules. Pharm Res. 15 (1998) 1026-1030
4. Chiwele I., Jones B.E., and Podczeck F. The shell dissolution of various empty hard capsules. Chem. Pharm. Bull. 48 (2000) 951-956
5. Cole E.T., Scott R.A., Cade D., Connor A.L., and Wilding I.R. In vitro and in vivo pharmacoscintigraphic evaluation of ibuprofen hypromellose and gelatin capsules. Pharm. Res. 21 (2004) 793-798
6. Digenis G.A., Sandefer E.P., Page R.C., Doll W.J., Gold T.B., and Darwazeh N.B. Bioequivalence study of stressed and non-stressed hard gelatin capsules using amoxicillin as a drug marker and gamma scintigraphy to confirm time and GI location of in vivo capsule rapture. Pharm. Res. 17 (2000) 572-582
7. Honkanen O., Seppa H., Eerlikainen S., Tuominen R., and Marvola M. Biovailability of ibuprofen from orally and rectally administerd hydroxypropyl methyl cellulose capsules compared to correponding gelatine capsules. STP Pharm. Sci. 11 (2001) 181-185
8. Honkanen O., Marvola J., Kanerva H., Lindevall K., Lipponen M., Kekki T., Ahonen A., and Marvola M. Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract. Eur. J. Pharm. Sci. 21 (2004) 671-678
9. Jones B.E. Powder formulations for capsule filling. Manufact. Chem. 59 (1998) 28-33
10. Jones B.E. The history of the medicinal capsule. In: Podczeck F., and Jones B.E. (Eds). Pharmaceutical Capsules. 2nd Ed. (2004), Pharmaceutical Press, London 1-22
11. Jones B.E. Manufacture and properties of two-piece hard capsule. In: Podczeck F., and Jones B.E. (Eds). Pharmaceutical Capsules. 2nd ed. (2004), Pharmaceutical Press, London 79-100
12. Nagata, S., Tochio, S., Sakuma, S., Suzuki, Y., 2001. Dissolution profiles of drugs filled into HPMC and gelatin capsules. AAPS PharmSci. 3 (3), abstract (http://www.aapspharmsci.org).
13. Ogura, T., Furuya, Y., Matsuura, S., 1998. HPMC capsules: an alternative to gelatin. Pharm. Tech. Eur., 11, pp. 32, 34, 36, 40, 42.
14. Perkins A.C., Wilson C.G., Blackshaw P.E., Vincent R.M., Dansereau R.J., Juhlin K.D., Bekker P.J., and Spiller R.C. Impaired oesophageal transit of capsule versus tablet formulation in the elderly. Gut 35 (1994) 1363-1367
15. Podczeck F., and Jones B.E. The in vitro dissolution of theophylline from different types of hard shell capsules. Drug. Dev. Ind. Pharm. 28 (2002) 1163-1169
16. Tochio S., Nagata, S., Yamashita, S., 2002. The influence of the composition of the test fluids on dissolution from HPMC capsules. AAPS PharmSci. 4(4), W4340. (http://www.aapspharmsci.org).
17. Tuleu C., Basit A.W., Waddington W.A., Ell P.J., and Newton J.M. Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose coated HPMC capsules. Aliment. Pharmacol. Ther. 16 (2002) 1771-1779
18. Wilson C.G., Washington N., Norman S., Greaves J.L., Peach J.M., and Pugh K. A gamma scintigraphic study to compare oesophageal clearance of "Expidet" formulations, tablets and capsules in supine volunteers. Int. J. Pharm. 46 (1988) 241-246