Remifentanil versus alfentanil: Comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers

Anesthesiology

Volumn 84, Issue 4, 1996, Pages 821-833

  Egan, Talmage D ^a,e   Minto, Charles F ^b   Hermann, David J ^c   Barr, Juliana ^b,d   Muir, Keith T ^c   Shafer, Steven L ^b,d  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d Palo Alto Veteran's Admin Med Ctr   (United States)

^e UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Analgesics, opioids: alfentanil; GI87084B; remifentanil; Pharmacodynamics: alfentanil; computer simulations; electroencephalography; GI87084B; population modeling; remifentanil; Pharmacokinetics: alfentanil; computer simulations; context sensitive half times; GI87084B; population modeling; remifentanil

Indexed keywords

ALFENTANIL; REMIFENTANIL;

ADULT; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG POTENCY; ELECTROENCEPHALOGRAM; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; ALFENTANIL; ANALGESICS, OPIOID; COMPUTER SIMULATION; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; HUMANS; MALE; MODELS, BIOLOGICAL; PIPERIDINES;

EID: 0029983237     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199604000-00009     Document Type: Article

References (28)

1. James MK, Feldman PL, Schuster SV, Bilotta JM, Brackeen MF, Leighton HJ: Opioid receptor activity of GI87084B, a novel ultra-short acting analgesic, in isolated tissues. J Pharmacol Exp Ther 1991; 259:712-8
2. Egan TD, Lemmens HJM, Fiset P, Hermann DJ, Muir KT, Stanski DR, Shafer SL: The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers. ANESTHESIOLOGY 1993; 79:881-92
3. Westmoreland CL, Hoke JF, Sebel PS, Hug CC, Muir KT: Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery. ANESTHESIOLOGY 1993; 79:893-903
4. Glass PSA, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D: Preliminary pharmacokinetics and pharmacodynamics of an ultra-short acting opioid: Remifentanil (G187084B). Anesth Analg 1993; 77:1031-40
5. Jasper HH: The ten twenty electrode system of the international federation. Electroencephalogr Clin Neurophysiol 1958; 10:371-5
6. Grosse CM, Davis IM, Arrendal RP, Jersey J, Amin J: Determination of remifentanil in human blood by liquid-liquid extraction and capillary GC-HRMS-SIM using a deuterated internal standard. J Pharm Biomed Anal 1994; 12:195-203
7. Jersey JA, Guyan S, Abbey L, Grosse CM, Davis IM: Determination of alfentanil in whole blood by GC/MS using liquid-liquid and solid phase extractions. Pharm Res 1993; 10(suppl):1180
8. Levy WJ, Shapiro HM, Maruchak G, Meathe E: Automated EEG processing for intraoperative monitoring: A comparison of techniques. ANESTHESIOLOGY 1980; 53:223-36
9. Yamaoka K, Nakagawa T, Uno T: Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978; 6:547-58
10. Gibaldi M, Perrier D: Absorption kinetics and bioavailability, Pharmacokinetics. 2nd edition. Edited by Swarbrick J. New York, Marcel Dekker, 1982, pp 145-98
11. Wagner JG: Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the data. J Pharmacokinet Biopharm 1976; 4:443-67
12. Hull CJ, van Beem HBH, Mcleod K, Sibbald A, Watson MJ: A pharmacodynamic model for pancuronium. BrJ Anaesth 1978; 50: 1113-23
13. Verotta D, Sheiner LB: Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm. Comput Appl Biosci 1987; 3:345-9
14. Holford NHG, Sheiner LB: Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models. Clin Pharmacokinet 1981; 6:429-53
15. Shafer SL, Varvel JR: Pharmacokinetics, pharmacodynamics and rational opioid selection. ANESTHESIOLOGY 1991; 74:53-63
16. Hughes MA, Glass PSA, Jacobs JR: Context-sensitive half-times in multicompartment pharmacokinetics models for intravenous anesthetic drugs. ANESTHESIOLOGY 1991; 76:334-41
17. Shafer SL, Stanski DR: Improving the clinical utility of anesthetic drug pharmacokinetics. ANESTHESIOLOGY 1992; 76:327-30
18. Scott JC, Stanski DR: Decreased fentanyl and alfentanil dose requirements with age: A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987; 240:159-66
19. Bovill JG, Sebel PS, Blackburn CL, Heykants J: The pharmacokinetics of alfentanil (R39209): A new opioid analgesic. ANESTHESIOLOGY 1982; 57:439-43
20. Youngs EJ, Shafer SL: Pharmacokinetic parameters relevant to recovery from opioids. ANESTHESIOLOGY 1994; 81:833-42
21. Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ: Design, synthesis, and pharmacological evaluation of ultrashort to long acting opioid analgetics. J Med Chem 1991; 34:2202-8
22. Stanski DR: Pharmacodynamic modeling of anesthetic EEG drug effects. Annu Rev Pharmacol Toxicol 1992; 32:423-47
23. Jacobs JR, Reves JG: Effect site equilibration time is a determinant of induction dose requirement. Anesth Analg 1993; 76:1-6
24. Scott JC, Ponganis KV, Stanski DR: EEG quantitation of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil. ANESTHESIOLOGY 1985; 62:234-41
25. Scott JC, Cooke JE, Stanski DR: Electroencephalographic quantitation of opioid effect: Comparative pharmacodynamics of fentanyl and sufentanil. ANESTHESIOLOGY 1991; 74:34-42
26. Meuldermans WEG, Hurkmans RMA, Heykants JJP: Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Arch Int Phramacodyn 1982; 257:4-19
27. Ebling WF, Lee EN, Stanski DR: Understanding pharmacokinetics and pharmacodynamics through computer simulation: I. The comparative clinical profiles of fentanyl and alfentanil. ANESTHESIOLOGY 1990; 72:650-8
28. Henthorn TK, Avram MJ, Krejcie TC, Shanks CA, Asada A, Kaczynski DA: Minimal compartmental model of circulatory mixing of indocyanine green. Am J Physiol 1992; 262:903-10.