20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 147, Issue 3, 2008, Pages 351-356

  Duan, Yin ^a   Nicholson, Russell A ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

20(S)Protopanaxadiol; l Glutamate and GABA release; Membrane potential; Mouse brain; Rh2; Sodium channel

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID RECEPTOR AFFECTING AGENT; BATRACHOTOXININ A 20ALPHA BENZOATE H 3; GINSENOSIDE RH 2; GLUTAMIC ACID; PROTOPANAXADIOL; RADIOPHARMACEUTICAL AGENT; SODIUM CHANNEL; UNCLASSIFIED DRUG; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; IC 50; MALE; MAMMAL; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL;

MAMMALIA;

EID: 39749173732     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2008.01.001     Document Type: Article

References (34)

1. Aiuchi T., Daimatsu T., Nakaya K., and Nakamura Y. Fluorescence changes of rhodamine 6G associated with changes in membrane potential in synaptosomes. Biochim. Biophys. Acta 685 (1982) 289-296
2. Choi S., Jung S.Y., Rhim H., Jeong S.W., Lee S.M., and Nah S.Y. Evidence that ginsenosides prevent the development of opioid tolerance at the central nervous system. Life Sci. 67 (2000) 969-975
3. Choi S., Jung S.Y., Kim C.H., Kim H.S., Rhim H., Kim S.C., and Nah S.Y. Effects of ginsenosides on voltage-dependent Ca2+ channel subtypes in bovine chromaffin cells. J. Ethnopharmacol. 74 (2001) 75-81
4. Choi S., Jung S.Y., Lee J.H., Sala F., Criado M., Mulet J., Valor L.M., Sala S., Engel A.G., and Nah S.Y. Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 442 (2002) 37-45
5. Choi S.E., Choi S., Lee J.H., Whiting P.J., Lee S.M., and Nah S.Y. Effects of ginsenosides on GABAA receptor channels expressed in Xenopus oocytes. Arch. Pharm. Res. (Seoul) 26 (2003) 28-33
6. Choi S., Lee J.H., Oh S., Rhim H., Lee S.M., and Nah S.Y. Effects of ginsenoside Rg2 on the 5-HT3A receptor mediated ion current in Xenopus oocytes. Mol. Cells 15 (2003) 108-113
7. 3H]batrachotoxinin A 20-α-benzoate binding to Na+ channels in mammalian brain. Eur. J. Pharmacol. 530 (2006) 9-14
8. 3H]batrachotoxinin A 20-α-benzoate binding to sodium channels and sodium channel function by endocannabinoids. Neurochem. Int. 52 (2008) 438-446
9. Dunkley P.R., Jarvie P.E., Heath G.W., Kidd G.J., and Rostas J.A.P. A rapid method for isolation of synaptosomes on percoll gradients. Brain Res. 372 (1986) 115-129
10. Einat H. Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders. Phytother. Res. 21 (2007) 62-66
11. Frizelle H.P., Moriarty D.C., and O'Connor J.J. The combined effects of halothane and lamotrigine on excitatory postsynaptic potentials and use-dependent block in the rat dentate gyrus in vitro. Anesth. Analg. 89 (1999) 496-501
12. Hahn J., Nah S.Y., Nah J.J., Uhm D.Y., and Chung S. Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons. Neurosci. Lett. 287 (2000) 45-48
13. Hao Y., Yang J.Y., Wu C.F., and Wu M.F. Pseudoginsenoside F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice. Pharmacol. Biochem. Behav. 86 (2007) 660-666
14. Harris R.A., and Allen A.M. Functional coupling of γ-aminobutyric acid receptors to chloride channels in brain membranes. Science 228 (1985) 1108-1110
15. Kim S., Kim T., Ahn K., Park W.K., Nah S.Y., and Rhim H. Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochem. Biophys. Res. Commun. 323 (2004) 416-424
16. Kim J.H., Hong Y.H., Lee J.H., Kim D.H., Nam G., Jeong S.M., Lee B.H., Lee S.M., and Nah S.Y. A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition. Mol. Cells 19 (2005) 137-142
17. Kim J.H., Cho S.Y., Lee J.H., Jeong S.M., Yoon I.S., Lee B.H., Lee J.H., Pyo M.K., Lee S.M., Chung J.M., Kim S., Rhim H., Oh J.W., and Nah S.Y. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res. 1136 (2007) 190-199
18. Lang D.G., Wang C.M., and Cooper B.R. Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J. Pharmacol. Exp. Ther. 266 (1993) 829-835
19. Leach M.J., Marden C.M., and Miller A.A. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 27 (1986) 490-497
20. Lee J.H., Jeong S.M., Kim J.H., Lee B.H., Yoon I.S., Lee J.H., Choi S.H., Kim D.H., Rhim H., Kim S.S., Kim J.I., Jang C.G., Song J.H., and Nah S.Y. Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition. Mol. Pharmacol. 68 (2005) 1114-1126
21. Lee J.H., Jeong S.M., Kim J.H., Lee B.H., Yoon I.S., Lee J.H., Choi S.H., Lee S.M., Park Y.S., Lee J.H., Kim S.S., Kim H.C., Lee B.Y., and Nah S.Y. Effects of ginsenosides and their metabolites on voltage-dependent Ca2+ channel subtypes. Mol. Cells 21 (2006) 52-62
22. Lee E., Kim S., Chung K.C., Choo M.K., Kim D.H., Nam G., and Rhim H. 20(S) ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur. J. Pharmacol. 536 (2006) 69-77
23. Lee B.H., Lee J.H., Lee S.M., Jeong S.M., Yoon I.S., Lee J.H., Choi S.H., Pyo M.K., Rhim H., Kim H.C., Jang C.G., Lee B.C., Park C.S., and Nah S.Y. Identification of ginsenoside interaction sites in 5-HT3A receptors. Neuropharmacolgy 52 (2007) 1139-1150
24. Liu D., Li B., Liu Y., Attele A.S., Kyle J.W., and Yuan C.S. Voltage-dependent inhibition of brain Na+ channels by American ginseng. Eur. J. Pharmacol. 413 (2001) 47-54
25. Mandala M., Serck-Hanssen G., Martino G., and Helle K.B. The fluorescent cationic dye rhodamine 6G as a probe for membrane potential in bovine aortic endothelial cells. Anal. Biochem. 274 (1999) 1-6
26. Nah S.Y., and McCleskey E.W. Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as β-opioids. J. Ethnopharmacol. 42 (1994) 45-51
27. Nicholson R.A., Liao C., Zheng J., David L.S., Coyne L., Errington A.C., Singh G., and Lees G. Sodium channel inhibition by anandamide and synthetic cannabimimetics in brain. Brain Res. 978 (2003) 194-204
28. Noh J.H., Choi S., Lee J.H., Betz H., Kim J.I., Park C.S., Lee S.M., and Nah S.Y. Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes. Mol. Cells 15 (2003) 34-39
29. Ratnakumari L., and Hemmings Jr. H.C. Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology 86 (1997) 428-439
30. Rhim H., Kim H., Lee D.Y., Oh T.H., and Nah S.Y. Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. Eur. J. Pharmacol. 436 (2002) 151-158
31. Tachikawa E., Kudo K., Hasegawa H., Kashimoto T., Sasaki K., Miyazaki M., Taira H., and Lindstrom J.M. In vitro inhibition of adrenal catecholamine secretion by steroidal metabolites of ginseng saponins. Biochem. Pharmacol. 66 (2003) 2213-2221
32. Takagi K., Saito H., and Nabata H. Pharmacological studies of Panax ginseng root: estimation of pharmacological actions of Panax ginseng root. Jpn. J. Pharmacol. 22 (1972) 245-259
33. Tsang D., Yeung H.W., Tso W.W., and Peck H. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med. 51 (1985) 221-224
34. Xue J.F., Liu Z.J., Hu J.F., Chen H., Zhang J.T., and Chen N.H. Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. Brain Res. 1106 (2006) 91-98