Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis

International Journal of Molecular Medicine

Volumn 28, Issue 6, 2011, Pages 1043-1047

  Ohara, Maki ^a,b   Kimura, Shinichi ^a   Tanaka, Aya ^a   Ohnishi, Ken ^a   Okayasu, Ryuichi ^c   Kubota, Nobuo ^a  

^a IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^b IBARAKI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Apoptosis; Benzyl isothiocyanate; Human pancreatic cancer cells; Radiosensitization

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZYL ISOTHIOCYANATE; CASPASE 9; INHIBITOR OF APOPTOSIS PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CLONOGENIC ASSAY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; RADIOSENSITIZATION; STAINING; WESTERN BLOTTING; X RAY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BLOTTING, WESTERN; CASPASE 9; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOTHIOCYANATES; MICROSCOPY, FLUORESCENCE; PANCREATIC NEOPLASMS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; UP-REGULATION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; X-RAYS;

EID: 80053541396     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.770     Document Type: Article

References (31)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C and Thun MJ: Cancer statistics, 2006. CA Cancer J Clin 56: 106-130, 2006.
2. Gudjonson B: Cancer of the pancreas. 50 years of surgery. Cancer 60: 2284-2303, 1987.
3. DiMagno EP, Reber HA and Tempero MA: AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology 117: 1464-1484, 1999.
4. Roy R and Maraveyas A: Chemoradiation in pancreatic adenocarcinoma: a literature review. Oncologist 15: 259-269, 2010.
5. Cohen JH, Kristal AR and Stanford JL: Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92: 61-68, 2000. (Pubitemid 30082230)
6. Verhoeven DT, Goldbohm RA, Van Poppel G, Verhagen H and Van den Brandt PA: Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 5: 733-748. 1996. (Pubitemid 26304649)
7. Fahet JW, Zalcmann AT and Talalay R: The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56: 5-51, 2001. (Pubitemid 32063165)
8. Zhang Y, Tang L and Gonzalez V: Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther 2: 1045-1052, 2003.
9. Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y and Singh SV: Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res 69: 3704-3712, 2009.
10. Miyoshi N, Uchida K, Osawa T and Nakamura Y: A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res 64: 2134-2142, 2004. (Pubitemid 38339464)
11. Zhang R, Loganathan S, Humphreys L and Srivastava SK: Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cells. J Nutr 136: 2728-2734, 2006. (Pubitemid 44771765)
12. Xiao D, Vogel V and Singh SV: Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol Cancer Ther 5: 2931-2945, 2006. (Pubitemid 44849021)
13. Srivastava SK and Singh SV: Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B human pancreatic cancer cells. Carcinogenesis 25: 1701-1709, 2004.
14. Sahu RP and Srivastava SK: The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J Natl Cancer Inst 101: 176-193, 2009.
15. Warin R, Xiao D, Arlotti JA, Bommareddy A and Singh SV: Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate. Mol Carcinog 49: 500-507, 2010.
16. Batra S, Sahu RP, Kandaia PK and Srivastava SK: Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. Mol Cancer Ther 9: 1596-1608, 2010.
17. Kuribayashi T, Ohara M, Sora S and Kubota N: Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. Int J Mol Med 25: 25-29, 2010.
18. Zhang Y, Jung M and Dritschilo A: Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161: 667-674, 2004. (Pubitemid 39149575)
19. Sahu RP, Epperly MW and Srivastava SK: Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation therapy. Front Biosci (Elite Ed) 1: 568-576, 2009.
20. Machida H, Nakajima S, Shikano N, Nishio J, Okada S, Asayama M, Shirai M and Kubota N: Heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer Sci 96: 911-917, 2005. (Pubitemid 43056131)
21. Kubota N, Ozawa F, Okada S, Inada T, Komatsu K and Okayasu R: The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation. Cancer Lett 133: 161-167, 1988.
22. Machida H, Matsumoto Y, Shirai M and Kubota N: Gendanamycin, an inhibitor of Hsp90, sensitizes human tumor cells to radiation. Int J Radiat Biol 79: 973-980, 2003. (Pubitemid 38147058)
23. El Maalouf G, Le Tourmeau C, Batty GN, Faivre S and Raymond E: Markers involved in resistance to cytotoxics and targeted therapeutics in pancreatic cancer. Cancer Treat Rev 35: 167-174, 2009.
24. Dorai T and Aggarwal BB: Role of chemopreventive agents in cancer therapy. Cancer Lett 215: 129-140, 2004. (Pubitemid 39370030)
25. Yu D, Sekine-Suzuki E, Xue L, Fujimori A, Kubota N and Okayasu R: Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells. Int J Cancer 125: 1205-1211, 2009.
26. Taylor RC, Cullen SP and Martin SJ: Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9: 231-241, 2008. (Pubitemid 351301823)
27. Riedl SJ and Salvesen GS: The apoptosome: signaling platform of cell death. Nat Rev Mol Cell Biol 8: 405-413, 2007. (Pubitemid 46643237)
28. Bao O and Shi Y: Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ 14: 56-65, 2007.
29. Deveraux QL and Reed JC: IAP family proteins - suppressors of apoptosis. Genes Dev 13: 239-252, 1999. (Pubitemid 29095796)
30. Kashkar H: X-linked inhibitor of apoptosis: chemoresistance factor or hollow promise. Clin Cancer Res 16: 4496-4502, 2010.
31. Shimmer AD, Dalili S, Batey RA and Riedl SJ: Targeting XIAP for the treatment of malignancy. Cell Death Differ 13: 179-188, 2006. (Pubitemid 43102202)