The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model

Experimental and Molecular Pathology

Volumn 91, Issue 3, 2011, Pages 653-659

  French, S W ^a   Bardag Gorce, F ^b   French, B A ^a   Li, J ^a   Oliva, J ^b  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b LA BIOMED ^*  (United States)

Author keywords

26S proteasome; Immunoproteasome; Mallory Denk bodies; Toll like receptors; Ubiquitin D

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEIN P53; STAT1 PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME ACTIVITY; EPIGENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NONHUMAN; PRECANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION; TOXIC HEPATITIS; UPREGULATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY, CHRONIC; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; LIVER NEOPLASMS; MICE; MICE, INBRED C3H; PRECANCEROUS CONDITIONS;

MUS;

EID: 80053535939     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.07.004     Document Type: Review

References (42)

1. Bardag-Gorce F., Oliva J., Villegas J., Fraley S., Amidi F., Li J., Dedes J., French B., French S.W. Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp. Mol. Pathol. 2008, 94:113-121.
2. Bardag-Gorce F., Oliva J., French B.A., Li J., Dedes J., French S.W. SAMe prevents the induction of immunoproteasome and preserves the 26S proteasomes in the DDC induced MDB; mouse model. Exp. Mol. Pathol. 2010, 88:352-362.
3. Bardag-Gorce F., Oliva J., Lin A., Li J., French B.A., French S.W. SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes. Exp. Mol. Pathol. 2010, 88:376-379.
4. Bardag-Gorce F., Oliva J., Li J., French B.A., French S.W. SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Exp. Mol. Pathol. 2010 Jun, 88(3):353-362.
5. Blackledge N.P., Klose R.J. Histone lysine methylation: an epigenetic modification?. Epigenetics 2010, 2:151-161.
6. Chen S., Bohrer L.R., Rai A.N., Pan Y., Gan L., Zhou X., Bagchi A., Simon J.A., Huang H. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of E2H2. Nature Cell Biol 2010, 121:1108-1114.
7. Franklin B.S., Panoche P., Ataide M.A., Lauw F., Ropert C., deOlivera R.B., Pereira D., Tada M.S., Noqueira P., daSilva L.H., Bjorkbacka H., Golenbock D.T., Gazzinelli R.T. Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci USA 2009, 106:5789-5794.
8. French S.W., Bardag-Gorce F., Li J., French B.A., Oliva J. Mallory-Denk body pathogenesis revisited. World J J Hepatol 2010, 2:295-301.
9. French S.W., Oliva J., French B.A., Bardag-Gorce F. Alcohol nutrition and liver cancer. Role of toll-like receptor signaling. World J. Gastroenterol. 2010, 16:1344-1348.
10. French S.W. Molecular events in hepatic preneoplasia: a review. Exp. Mol. Pathol. 2010, 88:219-224.
11. French B.A., Oliva J., Bardag-Gorce F., French S.W. The immunoproteasome in steatohepatitis: its role in Mallory-Denk body formation. Exp. Mol. Pathol. 2011, 90:252-256.
12. Gao B., Seki E., Brenner D.A., Friedman S., Cohen J., Cohen J.I., Nagy L., Szabo G., Zakhari S. Innate immunity in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2011, 300:G516-G525.
13. Howas C.J., Lamb C.L., Mitchell K.A. Regulation of hepatocyte fate by interferon-γ cytokine. Growth Factor Reviews 2011, 22:35-43.
14. Kloetzel P.M. Antigen processing by the proteasome. Nat. Rev. Mol. Cell Biol. 2001, 2:79-187.
15. Lingala S., Cui Y.-Y., Chen X., Ruebner B.H., Qian X.-F., Zern M.A., Wu J. Immunohistochemical staining of cancer stem cell markers in hepatocellular carcinoma. Exp. Mol. Pathol. 2010, 89:27-35.
16. Li J., Bardag-Gorce F., Dedes J., French B.A., Oliva J., Amidi F., French S.W. S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting epigenetic memory. Hepatology 2008, 47:613-624.
17. Lukasiak S., Schiller C., Oehischaeger P., Schmidtke G., Krause P., Legler D.F., Autobach F., Schmirmacher P., Breuhahn K., Groettrop M. Proinflammatory cytokines cause FAT10 up regulation in cancers of liver and colon. Oncogene 2008, 46:6068-6074.
18. Machida K. TLRs, Alcohol, HCV and Tumorigenesis 2010, 1-8. Gastroenterol Res Practice Hindaur Publ Corp, New York.
19. Machida K., Tsukamto H., Mkrkhiyan H., Duan L., Dynnyk A., Lin H.M., Asanina K., Govindaragan S., Ray R., Ou J.-H.-J., Seki E., Deshaies R., Miyake K., Lai M. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. PNAS 2009, 106:1548-1553.
20. Nagao Y., Yuan Q.-X., Wan Y-J Y., French B.A., French S.W. Pathogenesis of Mallory body formation: studies using the drug-primed mouse model. Hepatol Res 1998, 13(42-64):1998.
21. Nagao Y., Wan Y-J Y., Yuan Q.X., Kachi K., Marceau N., French S.W. Mouse model of hepatocellular hyperplastic nodule formation characterization of mRNA expression. Hepatol Res 1999, 15:110-123.
22. Nan L., Wu Y., Bardag-Gorce F., Li J., French B.A., Wilson L.T., French S.W. The p105/50NF-κB pathway is essential for Mallory body formation. Exp. Mol. Pathol. 2005, 78:198-206.
23. Nan L., Bardag-Gorce F., Wu Y., Li J., French B.A., French S.W. Mallory body forming cells express the preneoplastic hepatocyte phenotype. Exp Mol Path 2006, 80:109-118.
24. Nan L., Dedes J., French B.A., Bardag-Gorce F., Li J., Wu Y., French S.W. Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp. Mol. Pathol. 2006, 80:228-240.
25. Oliva J., Bardag-Gorce F., French B.A., Li J., McPhaul L., Amidi F., Dedes J., Habibi A., Nguyen S., French S.W. FAT10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp. Mol. Pathol. 2008, 84:107-112.
26. Oliva J., Bardag-Gorce F., Li J., French B.A., Nguyen S.K., Lu S.C., French S.W. Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms. Exp. Mol. Pathol. 2009, 86:77-86.
27. Oliva J., Bardag-Gorce F., Lin A., French B.A., French S.W. The role of cytokines in UbD promoter regulation and Mallory-Denk body-like aggresomes. Exp. Mol. Pathol. 2010, 89:1-8.
28. Oliva J., French B.A., Qing X., French S.W. The identification of stem cells in human liver diseases and hepatocellular carcinoma. Exp. Mol. Pathol. 2010, 88:331-340.
29. Oliva J., Bardag-Gorce F., Li J., French B.A., French S.W. S-Adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Exp. Mol. Pathol. 2011 Jun, 90(3):239-243.
30. Roomi M.W., Gaal K., Yuan Q.X., French B.A., Fu P., Bardag-Gorce F., French S.W. Preneoplastic liver cell foci induced by thioacetamide toxicity in drug primed liver. Exp. Mol. Pathol. 2006, 81:8-14.
31. Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 2004, 75:163-189.
32. Strehl B., Seifert U., Krüger E., Heink S., Kuckelkom U., Kloetzel P.M. Interferon-gamma, the functional plasticity of the ubiquity-proteasome system, and MHC class 1 antigen processing. Immunol. Rev. 2005, 207:19-30.
33. Szabo G., Mandrekar P., Dolganine A. Inmate immune response and hepatic inflammation. Semin. Liver Dis. 2007, 27:339-350.
34. Szabo G., Wands J.R., Eken A., Osna N.A., Weiman S.A., Machida K., Wang H.J. Alcohol and hepatitis C virus-interactions in immune dysfunctions and liver damage. Alcoholism: Clin Exp Res 2010, 34:1675-1686.
35. Tazawa J., Irie T., French S.W. Mallory body formation is linked to gamma glutamyl transferase induction in hepatocytes of griseofulvin-fed mice. Hepatology 1983, 3:989-1001.
36. Vasuri F., Capizzi E., Bellavista E., Mishto M., Santoro A., Fiorentino M., Capri M., Cescon M., Grazi G.L., Grigioni W.F., D'Errico-Grigionni A., Franceschi C. Studies on immunoproteasome in human liver. Part 1: absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis. Biochem. Biophys. Res. Commun. 2010, 397:301-306.
37. Villasante A., Piazzolla D., Li H., Gomez-Lopez G., Djabali M., Serrano M. Epigenetic regulation of Nanog expression by E2h2 in pluripotent stem cells. Cycle Cycle 2011, 110:1488-1498.
38. Wang H.L., Anatelli F., Zhai J., Adley B., Chuang S.-T., Yang X.J. Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions. Arch. Pathol. Lab. Med. 2008, 132:1723-1728.
39. Wu Y., Nan L., Bardag-Gorce F., Li J., French B.A., Wilson L.-T., Debes J., French S.W. The role of laminin-integrin signaling in triggering (MB) formation: an in vivo and in vitro study. Exp. Mol. Pathol. 2005, 79:1-8.
40. Yuan Q.X., Marceau N., French B.A., Fu P., French S.W. Mallory body induction in drug primed mouse liver. Hepatology 1996, 24:603-612.
41. Yuan Q.X., Nagao Y., French B.A., Wan Y.-J.Y., French S.W. Dexamethasone enhances Mallory body formation in drug-primed mouse liver. Exp. Mol. Pathol. 2000, 69:202-210.
42. Zeng X.Z., Chen S.A., Huang H.J. Phosphorylation of EZH2 by CDK1 and CDK2. A possible regulatory mechanism of transmission of the H3K27me3 epigenetic mark through cell divisions. Cell Cycle 2011, 10:579-583.