Alcohol, nutrition and liver cancer: Role of toll-like receptor signaling

World Journal of Gastroenterology

Volumn 16, Issue 11, 2010, Pages 1344-1348

  French, Samuel W ^a   Oliva, Joan ^a   French, Barbara A ^a   Li, Jun ^a   Bardag Gorce, Fawzia ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Alcohol; Drug toxicity; Epigenetic processes; Hepatocellular carcinoma; Inflammation; Lipopolysaccharides; Methyl donors; Toll like receptor

Indexed keywords

ALCOHOL; BETAINE; CARCINOGEN; LIPOPOLYSACCHARIDE; S ADENOSYLMETHIONINE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ALCOHOL LIVER DISEASE; ARTICLE; CANCER PREVENTION; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CHRONIC LIVER DISEASE; HEPATITIS B; HEPATITIS C; HUMAN; IMMUNE RESPONSE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NONHUMAN; NUTRITION; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION;

EID: 77950841093     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i11.1344     Document Type: Article

References (28)

1. Hassan MM, Hwang LY, Hatten CJ, Swaim M, Li D, Abbruzzese JL, Beasley P, Patt YZ. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology 2002; 36: 1206-1213
2. Britton RS, Bacon BR. Hereditary hemochromatosis and alcohol: a fibrogenic cocktail. Gastroenterology 2002; 122: 563-565
3. Kage M, Kage M, Liew CT, Xu Y, Peters RL. Alpha-1-antitrypsin deficiency in adults. Acta Pathol Jpn 1986; 36: 1139-1148
4. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci USA 2009; 106: 1548-1553
5. Oliva J, Bardag-Gorce F, French BA, Li J, McPhaul L, Amidi F, Dedes J, Habibi A, Nguyen S, French SW. Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis. Exp Mol Pathol 2008; 84: 102-112
6. Testro AG, Visvanathan K. Toll-like receptors and their role in gastrointestinal disease. J Gastroenterol Hepatol 2009; 24: 943-954
7. Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 2006; 44: 287-298
8. Wheeler MD. Endotoxin and Kupffer cell activation in alcoholic liver disease. Alcohol Res Health 2003; 27: 300-306
9. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G. The opposite effects of acute and chronic alcohol on lipopoly-saccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol 2009; 183: 1320-1327
10. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-759
11. Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G. The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 2008; 48: 1224-1231
12. E, Inokuchi S, Tsukamoto H, Brenner DA. Kupffer cells and stellate cells promote alcohol-mediated liver injury through TLR4. Hepatology 2009; 50 Suppl; A871
13. K, Liu J, Jeong H, Mishra L, Tsukamoto H. TLR4-dependent Nanog + cancer stem cells exhibit defective TGF-beta signaling. Hepatology 2009; 50 Suppl: A852
14. F, Oliva J, Li J, French BA, French SW. SAMe blocks the up regulation of Toll-like receptors signaling in Mallory-Denk body forming hepatocytes. Hepatology 2009; 50 Suppl: A867
15. Nan L, Bardag-Gorce F, Wu Y, Li J, French BA, French SW. Mallory body forming cells express the preneoplastic hepatocyte phenotype. Exp Mol Pathol 2006; 80: 109-118
16. Roomi MW, Gaal K, Yuan QX, French BA, Fu P, Bardag-Gorce F, French SW. Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice. Exp Mol Pathol 2006; 81: 8-14
17. Nagao Y, Yuan QX, Wan YJY, Barbara A. French BA, French SW. Pathogenesis of mallory body formation: studies using the drug-primed mouse model. Hepatol Res 1998; 13: 42-54
18. Bardag-Gorce F, Oliva J, Villegas J, Fraley S, Amidi F, Li J, Dedes J, French B, French SW. Epigenetic mechanisms regulate Mallory Denk body formation in the livers of drug-primed mice. Exp Mol Pathol 2008; 84: 113-121
19. Li J, Bardag-Gorce F, Dedes J, French BA, Amidi F, Oliva J, French SW. S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory. Hepatology 2008; 47: 613-624
20. Oliva J, Bardag-Gorce F, Li J, French BA, Nguyen SK, Lu SC, French SW. Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms. Exp Mol Pathol 2009; 86: 77-86
21. Nan L, Wu Y, Bardag-Gorce F, Li J, French BA, Wilson LT, French SW. The p105/50 NF-kappaB pathway is essential for Mallory body formation. Exp Mol Pathol 2005; 78: 198-206
22. Nagao Y, French BA, Cai Y, French SW, Wan YJ. Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis. J Cell Biochem 1998; 69: 189-200
23. Nan L, Dedes J, French BA, Bardag-Gorce F, Li J, Wu Y, French SW. Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor. Exp Mol Pathol 2006; 80: 228-240
24. Wu Y, Nan L, Bardag-Gorce F, Li J, French BA, Wilson LT, Dedes J, French SW. The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study. Exp Mol Pathol 2005; 79: 1-8
25. Yuan QX, Nagao Y, French BA, Wan YJ, French SW. Dexamethasone enhances mallory body formation in drug-primed mouse liver. Exp Mol Pathol 2000; 69: 202-210
26. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430: 257-263
27. J, Bardag-Gorce F, Li J, French BA, French SW. Mallory Denk body formation is associated with an increase of the immunoproteasome and a decrease of the 26S protea-some. FASEB J 2009; 24 Suppl; A219
28. Yao Z, Mishra L. Cancer stem cells and hepatocellular carcinoma. Cancer Biol Ther 2009; 8: 1691-1698